Results 51 to 60 of about 28,679 (286)
Lipotoxicity and type 2 diabetes in South Asians [PDF]
, 2020 People of South Asian ethnicity are at higher risk of type 2 diabetes (T2D) than people of European origin. The underlying causes for the higher susceptibility remain hard to pinpoint.
Muilwijk, M.
core
DataSheet6_Notoginsenoside R1 Ameliorates Cardiac Lipotoxicity Through AMPK Signaling Pathway.ZIP
, 2022 Aims: Cardiac lipotoxicity is the common consequence of lipid metabolism disorders in cardiomyocytes during development of heart failure (HF). Adenosine 5′monophosphate-activated protein kinase (AMPK) acts as an energy sensor and has a beneficial effect ...
Xue Tian (417237) +12 more
core +1 more source
DataSheet7_Notoginsenoside R1 Ameliorates Cardiac Lipotoxicity Through AMPK Signaling Pathway.ZIP
, 2022 Aims: Cardiac lipotoxicity is the common consequence of lipid metabolism disorders in cardiomyocytes during development of heart failure (HF). Adenosine 5′monophosphate-activated protein kinase (AMPK) acts as an energy sensor and has a beneficial effect ...
Xue Tian (417237) +12 more
core +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2010 Fatty liver disease comprises a spectrum ranging from simple steatosis to steatohepatitis which can progress to liver cirrhosis and hepatocellular cancer. Hepatic lipotoxicity may ensue when the hepatic capacity to utilize, store and export fatty acids (FA) as triglycerides is overwhelmed.
Trauner, Michael +2 more
openaire +4 more sources
Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity
Cell Death and Disease, 2023 Lipotoxicity, the accumulation of lipids in non-adipose tissues, alters the metabolic transcriptome and mitochondrial metabolism in skeletal muscle. The mechanisms involved remain poorly understood.
Sheree D. Martin +15 more
doaj +1 more source
Antioxidants, 2022 Lipotoxicity is an important factor in the development and progression of nonalcoholic steatohepatitis. Excessive accumulation of saturated fatty acids can increase the substrates of the mitochondrial electron transport chain in hepatocytes and cause the
Yangyang Wang +13 more
doaj +1 more source
DataSheet11_Notoginsenoside R1 Ameliorates Cardiac Lipotoxicity Through AMPK Signaling Pathway.ZIP
, 2022 Aims: Cardiac lipotoxicity is the common consequence of lipid metabolism disorders in cardiomyocytes during development of heart failure (HF). Adenosine 5′monophosphate-activated protein kinase (AMPK) acts as an energy sensor and has a beneficial effect ...
Xue Tian (417237) +12 more
core +1 more source
Ceramide is a cardiotoxin in lipotoxic cardiomyopathy [PDF]
Journal of Lipid Research, 2008 Ceramide is among a number of potential lipotoxic molecules that are thought to modulate cellular energy metabolism. The heart is one of the tissues thought to become dysfunctional due to excess lipid accumulation. Dilated lipotoxic cardiomyopathy, thought to be the result of diabetes and severe obesity, has been modeled in several genetically altered ...
Tae-Sik Park +10 more
openaire +3 more sources
A Lipid‐Conjugation Strategy for Intracellular Reactive Oxygen Species Control in Hepatic Cells
Angewandte Chemie, EarlyView.A lipid conjugation strategy anchors a manganese Salen complex within phospholipid membranes, yielding stable, catalytically active liposomes. These lipid–metal assemblies efficiently degrade reactive oxygen species (ROS) and enable intracellular redox control in steatotic HepaRG cells, offering a precise route to biomimetic antioxidant design ...
Olav Vestrheim +7 more
wiley +2 more sources
DataSheet9_Notoginsenoside R1 Ameliorates Cardiac Lipotoxicity Through AMPK Signaling Pathway.ZIP
, 2022 Aims: Cardiac lipotoxicity is the common consequence of lipid metabolism disorders in cardiomyocytes during development of heart failure (HF). Adenosine 5′monophosphate-activated protein kinase (AMPK) acts as an energy sensor and has a beneficial effect ...
Xue Tian (417237) +12 more
core +1 more source