Results 61 to 70 of about 28,679 (286)

DataSheet4_Notoginsenoside R1 Ameliorates Cardiac Lipotoxicity Through AMPK Signaling Pathway.ZIP

, 2022
Aims: Cardiac lipotoxicity is the common consequence of lipid metabolism disorders in cardiomyocytes during development of heart failure (HF). Adenosine 5′monophosphate-activated protein kinase (AMPK) acts as an energy sensor and has a beneficial effect ...
Xue Tian (417237), Yanyan Jiang (253354), Yiqin Hong (12253589), Mingyan Shao (5891174), Yong Wang (12837), Xu Chen (432759), Yawen Zhang (806754), Qianbin Sun (11750054), Qianqian Jiang (1448770), Tiantian Liu (548100), Ran Yang (519945), Qiyan Wang (3578858), Chun Li (57810)   +12 more
core   +1 more source

DMF-Activated Nrf2 Ameliorates Palmitic Acid Toxicity While Potentiates Ferroptosis Mediated Cell Death: Protective Role of the NO-Donor S-Nitroso-N-Acetylcysteine

Antioxidants, 2023
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease that can develop into an aggressive form called nonalcoholic steatohepatitis (NASH), which ultimately progresses to cirrhosis, hepatocellular carcinoma (HCC), and end ...
Diana Abu-Halaka, Adi Shpaizer, Haim Zeigerman, Joseph Kanner, Oren Tirosh   +4 more
doaj   +1 more source

Glutamine Modulates Macrophage Lipotoxicity [PDF]

Nutrients, 2016
Obesity and diabetes are associated with excessive inflammation and impaired wound healing. Increasing evidence suggests that macrophage dysfunction is responsible for these inflammatory defects. In the setting of excess nutrients, particularly dietary saturated fatty acids (SFAs), activated macrophages develop lysosome dysfunction, which triggers ...
He, Li, Weber, Kassandra J, Schilling, Joel D   +2 more
openaire   +3 more sources

Role of Lipotoxicity and Contribution of the Renin-Angiotensin System in the Development of Polycystic Ovary Syndrome

International Journal of Endocrinology, 2018
Polycystic ovary syndrome (PCOS) is a common and significant condition associated with hyperandrogenism, infertility, low quality of life, and metabolic comorbidities.
Alexandre Connolly, Samuel Leblanc, Jean-Patrice Baillargeon   +2 more
doaj   +1 more source

Lipotoxicity-Related Hematological Disorders in Obesity

, 2017
Lipotoxicity can mediate endothelial dysfunction in obesity. Altered endothelial cell phenotype during the pathobiological course of the lipotoxicity may lead to the hemostatic abnormalities, which is a hallmark of several hematological disorders ...
MALKAN, ÜMİT YAVUZ, HAZNEDAROĞLU, İBRAHİM CELALETTİN   +1 more
core   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Aqueous Extract of Pepino Leaves Ameliorates Palmitic Acid-Induced Hepatocellular Lipotoxicity via Inhibition of Endoplasmic Reticulum Stress and Apoptosis

Antioxidants, 2021
Saturated fatty acid is one of the important nutrients, but contributes to lipotoxicity in the liver, causing hepatic steatosis. Aqueous pepino leaf extract (AEPL) in the previous study revealed alleviated liver lipid accumulation in metabolic syndrome ...
Jen-Ying Hsu, Hui-Hsuan Lin, Charng-Cherng Chyau, Zhi-Hong Wang, Jing-Hsien Chen   +4 more
doaj   +1 more source

DataSheet5_Notoginsenoside R1 Ameliorates Cardiac Lipotoxicity Through AMPK Signaling Pathway.ZIP

, 2022
Aims: Cardiac lipotoxicity is the common consequence of lipid metabolism disorders in cardiomyocytes during development of heart failure (HF). Adenosine 5′monophosphate-activated protein kinase (AMPK) acts as an energy sensor and has a beneficial effect ...
Xue Tian (417237), Yanyan Jiang (253354), Yiqin Hong (12253589), Mingyan Shao (5891174), Yong Wang (12837), Xu Chen (432759), Yawen Zhang (806754), Qianbin Sun (11750054), Qianqian Jiang (1448770), Tiantian Liu (548100), Ran Yang (519945), Qiyan Wang (3578858), Chun Li (57810)   +12 more
core   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

The Coumarin-Derivative Esculetin Protects against Lipotoxicity in Primary Rat Hepatocytes via Attenuating JNK-Mediated Oxidative Stress and Attenuates Free Fatty Acid-Induced Lipid Accumulation

Antioxidants, 2023
Coumarin derivates have been proposed as a potential treatment for metabolic-dysfunction-associated fatty liver disease (MAFLD). However, the mechanisms underlying their beneficial effects remain unclear.
Mengmeng Xia, Zongmei Wu, Junyu Wang, Manon Buist-Homan, Han Moshage   +4 more
doaj   +1 more source