Results 71 to 80 of about 28,679 (286)

DataSheet12_Notoginsenoside R1 Ameliorates Cardiac Lipotoxicity Through AMPK Signaling Pathway.ZIP

, 2022
Aims: Cardiac lipotoxicity is the common consequence of lipid metabolism disorders in cardiomyocytes during development of heart failure (HF). Adenosine 5′monophosphate-activated protein kinase (AMPK) acts as an energy sensor and has a beneficial effect ...
Xue Tian (417237), Yanyan Jiang (253354), Yiqin Hong (12253589), Mingyan Shao (5891174), Yong Wang (12837), Xu Chen (432759), Yawen Zhang (806754), Qianbin Sun (11750054), Qianqian Jiang (1448770), Tiantian Liu (548100), Ran Yang (519945), Qiyan Wang (3578858), Chun Li (57810)   +12 more
core   +1 more source

Mechanisms of Lipotoxicity in the Cardiovascular System [PDF]

Current Hypertension Reports, 2012
Cardiovascular diseases account for approximately one third of all deaths globally. Obese and diabetic patients have a high likelihood of dying from complications associated with cardiovascular dysfunction. Obesity and diabetes increase circulating lipids that upon tissue uptake, may be stored as triglyceride, or may be metabolized in other pathways ...
Adam R, Wende, J David, Symons, E Dale, Abel   +2 more
openaire   +2 more sources

Hepatoma‐Derived Growth Factor Coordinates STAT3 Pathway and Exosome‐Mediated Intrahepatic Crosstalk to Control Hepatic Steatosis and MASLD

Advanced Science, EarlyView.
Hepatic HDGF as a key mediator in coordinating hepatic steatosis and intrahepatic crosstalk in MASLD. Activation of HDGF facilitates its interaction with both STAT3 and S6K1, driving the S6K1‐dependent STAT3 phosphorylation and subsequently enhancing hepatic lipogenesis.
Jian Wen, Dong Ding, Zengpeng Zheng, Xufeng Chen, Wenjing Li, Jiaxin Shen, Zhiwei Huang, Peng Tan, Junjie Bai, Xia Fang, Baofang Xing, Puyuan Hu, Linghao Xu, Haokai Yu, Yixi Wang, Zongzhe Jiang, Yang Long, Tiejun Zhou, Mingxin Ye, Yu Jiang, Aoyuan Cui, Hong Li, Qiurong Ding, Yong Xu, Yu Li, Weitong Su, Feng Shen, Chenlin Gao, Wenguang Fu   +28 more
wiley   +1 more source

Role of Sphingosine Kinase 1 in Glucolipotoxicity-Induced Early Activation of Autophagy in INS-1 Pancreatic β Cells

Cells
Insulin-producing pancreatic β cells play a crucial role in the regulation of glucose homeostasis, and their failure is a key event for diabetes development.
Nicolas Coant, Karima Rendja, Lara Bellini, Mélissa Flamment, Jeannine Lherminier, Bernard Portha, Patrice Codogno, Hervé Le Stunff   +7 more
doaj   +1 more source

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source

DataSheet2_Notoginsenoside R1 Ameliorates Cardiac Lipotoxicity Through AMPK Signaling Pathway.ZIP

, 2022
Aims: Cardiac lipotoxicity is the common consequence of lipid metabolism disorders in cardiomyocytes during development of heart failure (HF). Adenosine 5′monophosphate-activated protein kinase (AMPK) acts as an energy sensor and has a beneficial effect ...
Xue Tian (417237), Yanyan Jiang (253354), Yiqin Hong (12253589), Mingyan Shao (5891174), Yong Wang (12837), Xu Chen (432759), Yawen Zhang (806754), Qianbin Sun (11750054), Qianqian Jiang (1448770), Tiantian Liu (548100), Ran Yang (519945), Qiyan Wang (3578858), Chun Li (57810)   +12 more
core   +1 more source

Sexual Dimorphism in Inorganic Mercury Toxicokinetics and the Attendant Lipotoxic and Non-Lipotoxic Dyslipidemia in the Rat [PDF]

Biochemistry and Biophysics Reports, 2020
Abstract BackgroundThe influence of variability in the biology of living organisms is poorly appreciated in toxicology. However, multiple lines of evidence indicate that sex-differences modulate toxicokinetics and toxicodynamics from cellular/molecular to whole animal levels resulting in different toxic responses of living organisms to ...
A.D. Wusu, O.O. Ogunrinola, O.K. Afolabi, E.O. Abam, D.O. Babayemi, O.A. Dosumu, O.B. Onunkwor, E.A. Balogun, O.O. Odukoya, O. Ademuyiwa   +9 more
openaire   +3 more sources

Amplification of Endoplasmic Reticulum Stress via Inhibiting Lipid Droplet Formation to Enhance Chemodynamic Immunotherapy

Advanced Science, EarlyView.
An endoplasmic reticulum (ER)‐targeted chemodynamic nanoagent (TCBQ/iLD‐ER NPs) comprising •OH‐generating tetrachloro‐1,4‐benzoquinone (TCBQ) and lipid droplets (LDs) formation inhibitor (iLD) is developed for chemodynamic immunotherapy of tumors. After ingestion by cancer cells, TCBQ/iLD‐ER NPs preferentially accumulate in the ER and react with ER ...
Huilan Cai, Shaoru Zhuang, Yang Zhu, Rujiang Ao, Meili Yu, Tingting Cui, Jun Wang, Xuegang Niu, Hongwei Huang, Shanshan Peng, Yu He, Lisen Lin, Huanghao Yang   +12 more
wiley   +1 more source

Wheat germ oil vitamin E cytoprotective effect and its nutrigenomics signature in human hepatocyte lipotoxicity

Heliyon, 2022
Wheat germ oil (WGO) is rich in α-tocopherol (vitamin E, VE), a vitamin that has long been suggested to exert hepatoprotective effects. In this study, this function of WGO-VE and its transcriptomics fingerprint were investigated in comparison with RRR−α ...
Desirée Bartolini, Rita Marinelli, Anna Maria Stabile, Tiziana Frammartino, Angela Guerrini, Stefano Garetto, Jacopo Lucci, Anna Migni, Linda Zatini, Giada Marcantonini, Mario Rende, Francesco Galli   +11 more
doaj   +1 more source

DataSheet1_Notoginsenoside R1 Ameliorates Cardiac Lipotoxicity Through AMPK Signaling Pathway.ZIP

, 2022
Aims: Cardiac lipotoxicity is the common consequence of lipid metabolism disorders in cardiomyocytes during development of heart failure (HF). Adenosine 5′monophosphate-activated protein kinase (AMPK) acts as an energy sensor and has a beneficial effect ...
Xue Tian (417237), Yanyan Jiang (253354), Yiqin Hong (12253589), Mingyan Shao (5891174), Yong Wang (12837), Xu Chen (432759), Yawen Zhang (806754), Qianbin Sun (11750054), Qianqian Jiang (1448770), Tiantian Liu (548100), Ran Yang (519945), Qiyan Wang (3578858), Chun Li (57810)   +12 more
core   +1 more source