Results 151 to 160 of about 81,377 (299)

Post‐Translational Modifications of Key Proteins in Hematologic Malignancies: Carcinogenic Mechanisms, Biomarker Potential, and New Therapeutic Strategies

iLABMED, EarlyView.
This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han, Chaowei Zhang, Weiyi Yao, Qing Hong, Xinyu Tang, Yanan Zhu, Na Chen   +6 more
wiley   +1 more source

Functionally complementary bacterial inoculant coordinates arbuscular mycorrhizal fungi to improve Angelica sinensis root yield and quality

iMetaOmics, EarlyView.
Comprehensive understanding of how diverse PGPR strains enhance the rhizosphere microenvironment remains a considerable challenge. Here, we provide experimental evidence that a functionally synergistic composite microbial formulation can markedly enhance growth performance and improve the quality attributes in Angelica sinensis.
Zongyu Zhang, Yun Wang, Jiecai Zhao, Gaofeng Chen, Andéole Niyongabo Turatsinze, Liang Yue, Yuan Tian, Xiaofan Xie, Ailing Ye, Meilan Zhang, Lingling Wu, Zengxiang Guo, Yubao Zhang, Ruoyu Wang   +13 more
wiley   +1 more source

Early gut microbial and metabolic dysregulation with subclinical cardiac alterations in a nonhuman primate model of Rett syndrome

iMeta, EarlyView.
Longitudinal multi‐omics profiling of a nonhuman primate Rett syndrome (RTT) model reveals early systemic alterations. RTT monkeys exhibited postnatal growth retardation, intestinal structural abnormalities, and low‐grade systemic inflammation. Gut microbiome analysis showed delayed microbial maturation and age‐discordant dysbiosis, including altered ...
Ting Zhang, Xiaopeng Wang, Peng Li, Junyu Zhang, Wenjie Sun, Zhen Zhang, Yan Zhuo, Wenting Guo, Yongchang Chen   +8 more
wiley   +1 more source

Connecting a Western diet, palmitic acid, and enteric neuropathy. [PDF]

J Clin Invest
Ahima RS.
europepmc   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Beyond Glucose: Palmitic Acid Influences VEGFA-VEGFR2 Angiogenic Signaling in Müller Glial Cells. [PDF]

Int J Mol Sci
Albert-Garay JS, Medina Arellano AE, Hernández-Fonseca K, Medina-Sánchez T, Ruiz-Cruz M, Ochoa-de la Paz L.   +5 more
europepmc   +1 more source

Sleep deprivation aggravates hepatocytes steatosis and insulin resistance by regulating exosomal microRNAs

Interdisciplinary Medicine, EarlyView.
Sleep deprivation accelerates the progression of MASLD and IR by up‐regulating the expression of miR‐3572‐5p and down‐regulating the expression of miR‐183‐5p in circulating exosomes, thereby inhibiting fatty acid β‐oxidation and disrupting insulin signaling pathways. Abstract Sleep deprivation (SD) threatens human health and increases the prevalence of 
Xinxin Xu, Lulu Li, Ying Cao, Ying Wang, Chao Yang, Alexander Nikolaevich Orekhov, Yuanfeng Lu, Houbin Chu, Chuanrong Zhao, Guixue Wang, Guohua Song   +10 more
wiley   +1 more source

Epithelial-Mesenchymal Transition Shapes the Lipotoxic Response of Colon Cancer Cells to Palmitic Acid. [PDF]

Mol Cell Proteomics
Vari F, Serra I, Bisconti E, Stanca E, Raffo-Romero A, Mehenni S, Zirem Y, Vergara D, Fournier I, Giudetti AM, Salzet M.   +10 more
europepmc   +1 more source

A Morphological Study of Restoration of Damaged Hair Fiber With Chemical Treatments Using Microscopy Techniques

Microscopy Research and Technique, EarlyView.
Assessment of Restoring Chemically Damaged Hair Fibers Using Microscopy and Spectroscopy. ABSTRACT This paper analyses hair restoration products currently on the market that treat chemically processed hair. This study measured the restoration of structural integrity in hair samples from both chemically damaged hair (chemically relaxed, bleached, and ...
L. P. A. Mauricio, R. A. D. Cunha, S. M. Alves   +2 more
wiley   +1 more source

Biofertilization of canola seeds with Peribacillus simplex and Paenibacillus polymyxa bacteria increases tocopherol content

JSFA reports, EarlyView.
Abstract Background Biofertilization with plant growth‐promoting bacteria (PGPB) is a reliable strategy to reduce the amounts of chemical fertilizers applied to crops. Nevertheless, the effects of biofertilizers on plant chemical constituents that influence food quality and human health should be evaluated.
Pilar Martínez‐Hidalgo, José David Flores‐Félix, José M. Igual, Encarna Velázquez, Fernando González‐Andrés, Eustoquio Martínez‐Molina   +5 more
wiley   +1 more source