Results 221 to 230 of about 63,207 (314)

Gestational Melatonin Supplementation Attenuates Maternal Sleep Deprivation‐Induced Steatohepatitis Susceptibility in Offspring

Cell Proliferation, EarlyView.
Maternal SD during pregnancy enhances the development of diet‐induced NASH in adult offspring of both sexes through an NR4A3‐dependent mechanism, characterised by heightened inflammation and increased apoptosis. Maternal melatonin supplementation effectively alleviates this increased susceptibility to NASH in offspring.
Fei Guo, Zexin Yang, Junsen She, Chen Fang, Yizhi Hu, Hefeng Huang, Ling Gao   +6 more
wiley   +1 more source

Tryptophan derivatives as non‐invasive diagnostic indicators for obesity‐related MASLD in children and adolescents

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) represents a major health burden in children and adolescents with obesity. This study aimed to characterize metabolic alterations associated with obesity‐related MASLD and to evaluate the potential of tryptophan (TRP)‐derived metabolites as non‐invasive biomarkers for early ...
Shumin Zhan, Xingyun Wang, Chen Wang, Bowen Zhu, Jianfang Gao, Zhou Peng, Rui Wang, Yun Yang, Liang Zhang, Tengfei Wang, Jiaoxiang Wu, Wei Wu, Ke Huang, Guanping Dong, Qiannan Ren, Shan Wang, Senjie Wang, Xuelian Zhou, Liling Xu, Junfen Fu, Xirong Guo   +20 more
wiley   +1 more source

Enhanced mitochondrial respiration in peripheral blood mononuclear cells (PBMCs) from young children with overweight/obesity and insulin resistance

European Journal of Clinical Investigation, EarlyView.
We investigated measures of mitochondrial function in certain types of blood cells and metabolism in 65 children, 5–10 years old. Compared to children of normal weight (n = 20), children with overweight/obesity (n = 28) and especially those with insulin resistance (n = 17), differed in how their cells produced energy.
Eugenia Carvalho, Reid D. Landes, Matthew Cotter, Leanna M. Delhey, Elisabet Børsheim, Shannon Rose   +5 more
wiley   +1 more source

Lipidomic profiling unveils sex differences in diabetes risk: Implications for precision medicine

European Journal of Clinical Investigation, EarlyView.
This study uncovered sex‐specific metabolic and lipidomic signatures of prediabetes. In PREVADIAB2 (n = 953), clustering by insulin traits revealed four phenotypes. Lipidomics showed women enriched in dihydroceramides and sphingomyelins, while men displayed a higher ceramide/sphingomyelin ratio. These sex‐metabolic phenotypes expose distinct lipidomes,
Ana F. Pina, Maria João Meneses, Fabrizia Carli, Rogério T. Ribeiro, Luís Gardete‐Correia, José M. Boavida, João F. Raposo, Amalia Gastaldelli, M. Paula Macedo   +8 more
wiley   +1 more source

Artificial lipidation of proteins and peptides: from mechanism to clinical applications

The FEBS Journal, EarlyView.
Artificial lipidation transforms protein and peptide therapeutics by attaching fatty acid chains through reversible or permanent chemical strategies. This biomimetic approach delivers four key therapeutic advantages: extended circulation times (enabling weekly instead of daily dosing), alternative administration routes including oral delivery, precise ...
Jiaming Mu, Emily Vong, Sheiliza Carmali
wiley   +1 more source

Streaming potential analysis of hair variation: Ethnicities and environmental exposures

International Journal of Cosmetic Science, EarlyView.
Ethnicity and weathering shape electrokinetic behaviour and particle deposition in hair. ζ‐potential magnitudes ranked Caucasian > Indian > Chinese with no significant root‐tip variations. Deposition patterns generally correlate with ζ‐potential but differ by ethnicity, implicating other factors.
Huijun Phoebe Tham, Kah Yuen Yip, Thomas L. Dawson Jr   +2 more
wiley   +1 more source

Enzymatic synthesis of structured triacylglycerols (sTAGs) highly rich in palmitic acid at position 2 and caprylic acid at positions 1 and 3

, 2009
M. J. Jiménez, Luis Esteban, Alfonso Robles Medina, Estrella Hita, L. Martín, Alicia Rodrı́guez, Pedro A. González, Emilio Molina   +7 more
openalex   +1 more source

Palmitic Acid Accelerates Endothelial Cell Injury and Cardiovascular Dysfunction via Palmitoylation of PKM2. [PDF]

Adv Sci (Weinh)
He Y, Li S, Jiang L, Wu K, Chen S, Su L, Liu C, Liu P, Luo W, Zhong S, Li Z.   +10 more
europepmc   +1 more source

Influence of the nature of the sterol on the behavior of palmitic acid/sterol mixtures and their derived liposomes

, 2010
Zhong‐Kai Cui, Guillaume Bastiat, Chester Jin, Amir Keyvanloo, Michel Lafleur   +4 more
openalex   +1 more source

Almost billfish: convergent longirostry, micro‐dentition, and possible glandular sinuses in a large teleost fish from the Upper Cretaceous of Northern Italy

Journal of Anatomy, EarlyView.
A fossil rostrum fragment of a large teleost fish from the Upper Cretaceous of Northern Italy reveals remarkable anatomical convergences with Cenozoic and Recent billfishes (marlins, swordfishes, and akin). The extinct group Plethodidae independently acquired a long snout, micro‐teeth, and oil‐gland sinuses well before the evolution of true billfishes.
Giovanni Serafini, Jürgen Kriwet, Tommaso Toldo, Eliana Fornaciari, Jacopo Amalfitano, Giorgio Carnevale   +5 more
wiley   +1 more source