Results 21 to 30 of about 5,176,832 (349)

Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis

Nutrition and Metabolism, 2020
Background Pyroptosis is a novel programmed cell death. It is identified as caspase-1 dependent and characterized by plasma-membrane rupture and release of proinflammatory intracellular contents inculuding IL-1 beta and IL-18. Pyroptosis is distinct from
Xin Zeng, Min Zhu, Xiaohong Liu, Xuan-min Chen, Yujia Yuan, Lan Li, Jingping Liu, Yanrong Lu, Jingqiu Cheng, Younan Chen   +9 more
semanticscholar   +1 more source

The apparent transfer of fatty acid from phosphatidylcholine to phosphatidylethanolamine in human erythrocytes

Journal of Lipid Research, 1971
In previous studies an apparent transfer of 14C-labeled fatty acid from phosphatidylcholine to phosphatidylethanolamine was observed in prelabeled human erythrocytes reincubated in fresh serum.
STEPHEN B. SHOHET
doaj   +1 more source

Palmitic acid stimulates glucose incorporation in the adipocyte by a mechanism likely involving intracellular calcium.

Journal of Lipid Research, 1989
The effect of palmitic acid on basal and insulin-stimulated incorporation of glucose into rat adipocytes was studied. Palmitic acid (2.40 mM) stimulated basal as well as insulin-stimulated glucose incorporation in rat adipocytes three and twofold ...
J Thode, H A Pershadsingh, J H Ladenson, R Hardy, J M McDonald   +4 more
doaj   +1 more source

Protection of palmitic acid-mediated lipotoxicity by arachidonic acid via channeling of palmitic acid into triglycerides in C2C12 [PDF]

Journal of Biomedical Science, 2014
Excessive saturated fatty acids have been considered to be one of major contributing factors for the dysfunction of skeletal muscle cells as well as pancreatic beta cells, leading to the pathogenesis of type 2 diabetes.PA induced cell death in a dose dependent manner up to 1.5 mM, but AA protected substantially lipotoxicity caused by PA at even low ...
Cheon, Hyae Gyeong, Cho, Young Sik
openaire   +3 more sources

The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms

Inflammation Research, 2019
Palmitic acid is a saturated fatty acid whose blood concentration is elevated in obese patients. This causes inflammatory responses, where toll-like receptors (TLR), TLR2 and TLR4, play an important role.
J. Korbecki, K. Bajdak-Rusinek
semanticscholar   +1 more source

Palmitic Acid Versus Stearic Acid: Effects of Interesterification and Intakes on Cardiometabolic Risk Markers—A Systematic Review

Nutrients, 2020
Fats that are rich in palmitic or stearic acids can be interesterified to increase their applicability for the production of certain foods. When compared with palmitic acid, stearic acid lowers low-density lipoprotein (LDL)-cholesterol, which is a well ...
M. V. van Rooijen, R. Mensink
semanticscholar   +1 more source

Palmitic acid content in savoury baked goods and modelled trend intake prior and post EU trans-fat regulation. [PDF]

Eur J Nutr
Kotopoulou S, Marakis G, Papanastasiou D, Skoulika S, Papaioannou A, Boukouvalas G, Mousia Z, Tzoumanika F, Karpouza A, Zampelas A, Magriplis E.   +10 more
europepmc   +3 more sources

Palmitic Acid Affects Intestinal Epithelial Barrier Integrity and Permeability In Vitro

Antioxidants, 2020
Palmitic acid (PA), a long-chain saturated fatty acid, might activate innate immune cells. PA plays a role in chronic liver disease, diabetes and Crohn’s disease, all of which are associated with impaired intestinal permeability.
M. Gori, A. Altomare, S. Cocca, E. Solida, M. Ribolsi, S. Carotti, A. Rainer, M. Francesconi, S. Morini, M. Cicala, Michele Pier Luca Guarino   +10 more
semanticscholar   +1 more source

Palmitic acid stimulates NLRP3 inflammasome activation through TLR4-NF-κB signal pathway in hepatic stellate cells

Annals of Translational Medicine, 2020
Background The NLRP3 inflammasome activation plays an important role in the development of NASH and fibrogenesis. However, the mechanisms involved in NLRP3 activation in hepatic stellate cells (HSCs) have been unclear.
Zhi-xia Dong, Zhuang Qian, Min Ning, Shan Wu, Lungen Lu, Xinjian Wan   +5 more
semanticscholar   +1 more source

Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes

Lipids in Health and Disease, 2011
Background Hepatic inflammation and degeneration induced by lipid depositions may be the major cause of nonalcoholic fatty liver disease (NAFLD). In this study, we investigated the effects of saturated and unsaturated fatty acids (FA) on apoptosis in ...
Dong Lei, Shi Hongyang, Yang Xia, Zhang Yong, Bai Jian   +4 more
doaj   +1 more source