Results 41 to 50 of about 5,176,832 (349)

Toll-like receptor 4 is a master regulator for colorectal cancer growth under high-fat diet by programming cancer metabolism

Cell Death and Disease, 2021
Although high-fat diet (HFD) has been implicated in the development of colorectal cancer (CRC), the critical signaling molecule that mediates the cancer growth is not well-defined.
Xianjing Hu, Sarwat Fatima, Minting Chen, Keyang Xu, Chunhua Huang, Rui-Hong Gong, Tao Su, Hoi Leong Xavier Wong, Zhaoxiang Bian, Hiu Yee Kwan   +9 more
doaj   +1 more source

Palmitic Acid Downregulates Thyroglobulin (Tg), Sodium Iodide Symporter (NIS), and Thyroperoxidase (TPO) in Human Primary Thyrocytes: A Potential Mechanism by Which Lipotoxicity Affects Thyroid?

International Journal of Endocrinology, 2018
Our previous studies suggested that the thyroid might be a target organ affected by lipotoxicity, which might be partially related to the increasing prevalence of subclinical hypothyroidism.
Meng Zhao, Xiaohan Zhang, Ling Gao, Yongfeng Song, Chao Xu, Chunxiao Yu, Shanshan Shao, Jiajun Zhao   +7 more
doaj   +1 more source

Palmitic Acid Induces Production of Proinflammatory Cytokines Interleukin-6, Interleukin-1β, and Tumor Necrosis Factor-α via a NF-κB-Dependent Mechanism in HaCaT Keratinocytes

Mediators of Inflammation, 2013
To investigate whether palmitic acid can be responsible for the induction of inflammatory processes, HaCaT keratinocytes were treated with palmitic acid at pathophysiologically relevant concentrations.
Bing-rong Zhou, Jia-an Zhang, Qian Zhang, Felicia Permatasari, Yang Xu, Di Wu, Zhi-qiang Yin, Dan Luo   +7 more
doaj   +1 more source

High-density lipoprotein ameliorates palmitic acid-induced lipotoxicity and oxidative dysfunction in H9c2 cardiomyoblast cells via ROS suppression

Nutrition and Metabolism, 2019
BackgroundHigh levels circulating saturated fatty acids are associated with diabetes, obesity and hyperlipidemia. In heart, the accumulation of saturated fatty acids has been determined to play a role in the development of heart failure and diabetic ...
Kuen-Ming Wu, Y. Hsu, Mei-Chin Ying, F. Tsai, Chang-Hai Tsai, Jing-Gung Chung, Jai-Sing Yang, Chih-Hsin Tang, Li-Yi Cheng, Po-Hua Su, V. Viswanadha, W. Kuo, Chih-Yang Huang   +12 more
semanticscholar   +1 more source

Determination and correlation analysis of tobacco non-volatile organic acids and pH

Shipin yu jixie, 2022
Objective: To explore the effects of organic acids on tobacco pH and flue gas pH. Methods: 34 kinds of single-grade tobacco and 11 kinds of finished cigarettes were taken as the research objects, and their non-volatile organic acids, tobacco pH, and the ...
PIAO Yong-ge, ZHANG Jia-bao, CUI Cheng-zhe, LIU You-jie, LI He-lin, LI Rui-li, ZHANG Jun-song   +6 more
doaj   +1 more source

Stimulation of fatty acid oxidation by a 3-thia fatty acid reduces triacylglycerol secretion in cultured rat hepatocytes.

Journal of Lipid Research, 1994
The present work shows that when mitochondrial beta-oxidation is stimulated by the hypolipemic, non-beta-oxidizable fatty acid analogue tetradecylthioacetic acid, there is a decrease in the secretion of triacylglycerol in cultured rat hepatocytes.
S Skrede, J Bremer, R K Berge, A C Rustan   +3 more
doaj   +1 more source

Enzymatic Formation of Hexadecenoic Acid from Palmitic Acid

Agricultural and Biological Chemistry, 1975
Desaturation of palmitic acid was investigated in an enzyme system prepared from rat liver. 2-trans-Hexadecenoic acid as well as 9-cis-hexadecenoic acid (palmitoleic acid) were found to be formed as monoenoic acid in this system.
Masuo NAKANO, Yasuhiko FUJINO
openaire   +2 more sources

Augmentation of Glucotoxicity, Oxidative Stress, Apoptosis and Mitochondrial Dysfunction in HepG2 Cells by Palmitic Acid

Nutrients, 2019
Hyperglycemia and hyperlipidemia are the hallmarks of diabetes and obesity. Experimental and epidemiological studies have suggested that dietary management and caloric restriction are beneficial in reducing the complications of diabesity.
Arwa Alnahdi, A. John, H. Raza
semanticscholar   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Ameliorative effects of polyunsaturated fatty acids against palmitic acid-induced insulin resistance in L6 skeletal muscle cells

Lipids in Health and Disease, 2012
Background Fatty acid-induced insulin resistance and impaired glucose uptake activity in muscle cells are fundamental events in the development of type 2 diabetes and hyperglycemia.
Sawada Keisuke, Kawabata Kyuichi, Yamashita Takatoshi, Kawasaki Kengo, Yamamoto Norio, Ashida Hitoshi   +5 more
doaj   +1 more source