Results 111 to 120 of about 5,148,482 (377)

Augmentation of Glucotoxicity, Oxidative Stress, Apoptosis and Mitochondrial Dysfunction in HepG2 Cells by Palmitic Acid

Nutrients, 2019
Hyperglycemia and hyperlipidemia are the hallmarks of diabetes and obesity. Experimental and epidemiological studies have suggested that dietary management and caloric restriction are beneficial in reducing the complications of diabesity.
Arwa Alnahdi, A. John, H. Raza
semanticscholar   +1 more source

Nonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2+PIRB+ Macrophages Through the ANGPTL8/PIRB/ALOX5AP Axis

Advanced Science, EarlyView.
The ANGPTL8/PIRB/ALOX5AP axis mediates liver‐kidney crosstalk. Hepatocytes secrete ANGPTL8, which binds to CCR2+PIRB+ macrophages in the kidneys, affecting the expression of ALOX5AP and enhancing the activation of these macrophages. Activated cells produce TGF‐β, IL‐6, and IL‐23, driving Th17 activation and promote the formation of myofibroblasts ...
Shuqi Wei, Diwen Shou, Siyuan Huang, Yingsi Wang, Quanzhen Liu, Jinfa Liu, Xiaoyu Lv, Yuyi Zeng, Liting Wei, Han Lin, Jiechuan Chen, Yangxiao Chen, Haoyu Zhong, Yanqing Zhou, Wen Ma, Li Wang, Guojun Qian, Jing Guo, Donglin Sun   +18 more
wiley   +1 more source

Influence of hight - fat diets with different fatty-acid composition on rat periodontal condition

Journal of Education, Health and Sport, 2017
Aim: Determine the effect of high-fat diets (HFD) with different fatty acid composition on the condition of the gums of rats. Materials and Methods: 4 types of edible fats were used: sunflower oil ( main acid - linoleic), olive oil (main acid -oleic ...
A. V. Markov
doaj   +3 more sources

Palmitic Acid-Rich High Fat Diet Exacerbates Experimental Pulmonary Fibrosis by Modulating Endoplasmic Reticulum Stress.

American Journal of Respiratory Cell and Molecular Biology, 2019
The impact of lipotoxicity on the development of lung fibrosis is unclear. Saturated fatty acids such as palmitic acid (PA) activate endoplasmic reticulum (ER) stress, a cellular stress response associated with the development of idiopathic pulmonary ...
S. Chu, J. Villalba, Xiaoliang Liang, K. Xiong, K. Tsoyi, B. Ith, Ehab A. Ayaub, R. Tatituri, D. Byers, F. Hsu, S. El-Chemaly, E. Kim, Yuanyuan Shi, I. Rosas   +13 more
semanticscholar   +1 more source

Nutritional c‐Fos Induction Rewires Hepatic Metabolism and Can Promote Obesity‐Associated Hepatocellular Carcinoma

Advanced Science, EarlyView.
It is shown that hepatic c‐Fos responds to feeding, altering de novo lipogenesis, glycolysis, and a wide range of steatosis‐associated metabolic signaling pathways. Obesogenic diets cause hepatic c‐Fos overexpression, insulin resistance, and the induction of metabolic reprogramming‐related genes.
Ao Li, Eduardo H. Gilglioni, Wadsen St‐Pierre‐Wijckmans, Leila Hosseinzadeh, Christelle Veyrat‐Durebex, Sumeet Pal Singh, Roberto Coppari, Latifa Bakiri, Esteban N. Gurzov   +8 more
wiley   +1 more source

Fatty acids and composition of their important groups in milk fat of Czech Pied cattle

Czech Journal of Animal Science, 2006
In 2003, 2004 and 2005 milk fat composition was determined three times in 55 dairy cows of Czech Pied cattle housed in a byre with stanchions and fed under conditions usual on Czech production farms.
M. Pešek, E. Samková, J. Špička
doaj   +1 more source

Acute effects of elevated NEFA on vascular function: a comparison of SFA and MUFA [PDF]

, 2010
There is emerging evidence to show that high levels of NEFA contribute to endothelial dysfunction and impaired insulin sensitivity. However, the impact of NEFA composition remains unclear.
Abby K. Thompson, Beysen, Christine M. Williams, Hogikyan, John Wright, Katie J. Newens, Kim G. Jackson, Wang, Xiao-Yun, Zampelas   +9 more
core   +1 more source

Mechanistic Insights in Surface Engineering of Micro‐/Nanocomposite Phase Change Materials for Thermal Energy Storage: A Review

Advanced Energy and Sustainability Research, EarlyView.
This review examines surface‐engineered phase change material composites as vital solutions for escalating thermal energy storage demands driven by urbanization. It elucidates their enhanced performance through chemical mechanisms, diverse compositions, and preparation strategies, emphasizing the role of carbon‐based additives in improving thermal ...
Laxman Singh, Saravanakumar Balakrishnan, Joseph Johnson William, Sheikdawood Parveen, Ponnachiyur Aruchamy Periasamy, Rajeev Kumar, Anshuman Srivastava, Sunil Kumar, Amit Kumar Shringi, Dimple Kumari, Ambrish Singh, Fei Yan   +11 more
wiley   +1 more source

Trans-Fats Inhibit Autophagy Induced by Saturated Fatty Acids

EBioMedicine, 2018
Depending on the length of their carbon backbone and their saturation status, natural fatty acids have rather distinct biological effects. Thus, longevity of model organisms is increased by extra supply of the most abundant natural cis-unsaturated fatty ...
Allan Sauvat, Guo Chen, Kevin Müller, Mingming Tong, Fanny Aprahamian, Sylvère Durand, Giulia Cerrato, Lucillia Bezu, Marion Leduc, Joakim Franz, Patrick Rockenfeller, Junichi Sadoshima, Frank Madeo, Oliver Kepp, Guido Kroemer   +14 more
doaj   +1 more source

Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2

Nature Communications, 2017
Obesity increases the risk for a number of diseases including cardiovascular diseases and type 2 diabetes. Excess saturated fatty acids (SFAs) in obesity play a significant role in cardiovascular diseases by activating innate immunity responses. However,
Yi Wang, Yuanyuan Qian, Qilu Fang, Peng Zhong, Weixin Li, Lintao Wang, Weitao Fu, Yali Zhang, Zheng Xu, Xiaokun Li, G. Liang   +10 more
semanticscholar   +1 more source