Results 31 to 40 of about 92,966 (245)
Hepatology, EarlyView., 2022 Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai +29 more
wiley +1 more source
Nutrients retention in functional beef burgers with especial emphasis on lipid profile [PDF]
, 2014 The true retention values of nutrients, with particular reference to fatty acids of dietary importance, were investigated in burgers with none or half of the pork backfat replaced with soybean oil ?healthier burgers (HB)- added with 0g/kg, 5g/kg, 10g/kg
Doval, Mirtha Marina +3 more
core +1 more source
Angewandte Chemie, EarlyView.This study introduces an integrated analytical and bioinformatics platform for high‐throughput tracing of lipid metabolism using bioorthogonal alkyne fatty acids and optimized LC‐MS workflow. Applied to human fibrosarcoma cells, the method traced fatty acid metabolism, revealing nuances in sphingolipid routing and metabolic bottlenecks, highlighting ...
Palina Nepachalovich +7 more
wiley +2 more sources
Effect of α-Bromo-palmitate on the Oxidation of Palmitic Acid by Rat Liver Cells
Journal of Biological Chemistry, 1971 Abstract Rat liver cell suspensions oxidized [1-14C]palmitic acid and [1-14C]palmitoyl-l-carnitine efficiently to CO2. Oxidation of tracer amounts of palmitate was inhibited by α-bromo-palmitate (2 x 10-4 m). The oxidation of tracer amounts of palmitoyl-l-carnitine was not affected.
F. D. Sauer, S. Mahadevan
openaire +3 more sources
Advanced Science, EarlyView.TRIM25‐mediated ubiquitination of INSIG1 serves as a key driver of lipid metabolism dysregulation in MASH progression. It identifies a novel small‐molecule inhibitor, C27H26N2O4S, which effectively inhibits TRIM25 activity, reducing lipid accumulation and inflammation.
Hao Zhang +8 more
wiley +1 more source
Advanced Science, EarlyView.The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang +12 more
wiley +1 more source
Enzymatic Formation of Hexadecenoic Acid from Palmitic Acid
Agricultural and Biological Chemistry, 1975 Desaturation of palmitic acid was investigated in an enzyme system prepared from rat liver. 2-trans-Hexadecenoic acid as well as 9-cis-hexadecenoic acid (palmitoleic acid) were found to be formed as monoenoic acid in this system.
Masuo Nakano, Yasuhiko Fujino
openaire +3 more sources
Gelsolin's Protective Role in MASH through F‐Actin Regulation and P53 Degradation
Advanced Science, EarlyView.Gelsolin (GSN) maintains liver metabolic homeostasis by promoting MDM2‐mediated P53 degradation and inhibiting F‐actin/Yes‐associated protein (YAP) overactivation. Loss of GSN impairs P53 degradation, increases lipid deposition, and enhances YAP‐driven fibrosis and inflammation in metabolic‐associated steatohepatitis.
Yiwei Lu +9 more
wiley +1 more source
Determination of the Chemical Composition of Grape Seed Powders by Gc-ms Analysis [PDF]
, 2018 Substantiation of the expedience of using of natural antioxidants for inhibiting of oxidative and hydrolytic rancidity in confectionary industry is an urgent direction.
Gorodyska, O. (Olena) +3 more
core +2 more sources
Preparation of photothermal palmitic acid/cholesterol liposomes
Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2018 AbstractIndocyanine green (ICG) is the only FDA‐approved near‐infrared dye and it is currently used clinically for diagnostic applications. However, there is significant interest in using ICG for triggered drug delivery applications and heat ablation therapy. Unfortunately, free ICG has a short half‐life in vivo and is rapidly cleared from circulation.
Chase S. Linsley +3 more
openaire +4 more sources