Results 81 to 90 of about 106,933 (288)

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

Advanced Science, EarlyView.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang, Tingting Tong, Pengxi Shi, Xiaofan Chen, Chenhao Wang, Qingyuan Weng, Sihan Chen, Linli Que, Qi Chen, Yuehua Li, Qiang Zhu, Jiantao Li   +11 more
wiley   +1 more source

Incorporation of acetate into fatty acids and lecithin by lung slices from fetal and newborn lambs

Journal of Lipid Research, 1967
Incorporation of acetate-1-14 into phospholipids and fatty acids by lung slices from fetal and newborn lambs and from ewes was studied in vitro. The distribution of radioactivity in the fatty acids of neutral lipids, phospholipids, and lecithin was ...
Nobukazu Chida, Forrest H. Adams
doaj   +1 more source

CYP52X1, representing new cytochrome P450 subfamily, displays fatty acid hydroxylase activity and contributes to virulence and growth on insect cuticular substrates in entomopathogenic fungus Beauveria bassiana [PDF]

, 2012
Infection of insects by the entomopathogenic fungus Beauveria bassiana proceeds via attachment and penetration of the host cuticle. The outermost epicuticular layer or waxy layer of the insect represents a structure rich in lipids including abundant ...
Bernard, Grausem, Keyhani, Nemat O., Lesot, Agnes, Pedrini, Nicolás, Pinot, Franck, Widemann, Emilie, Zhang, Shizhu   +6 more
core   +2 more sources

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

Membrane lipidome reorganization correlates with the fate of neuroblastoma cells supplemented with fatty acids. [PDF]

PLoS ONE, 2013
Palmitic acid is known to be apoptotic for nervous cells but no data are available on membrane lipidome transformations occurring during its supplementation, although membrane lipids are clearly involved in the apoptotic signaling cascade.
Andrea Bolognesi, Alexandros Chatgilialoglu, Letizia Polito, Carla Ferreri   +3 more
doaj   +1 more source

Fatty acid composition of Mediterranean buffalo milk fat [PDF]

, 2007
The purpose of this research was to investigate the variation in fatty acid composition of milk fat from four buffalo (Bubalus bubalis) herds under different feeding management and ration composition. Changes in milk fatty acid composition were monitored
DI FRANCIA, ANTONIO, MASUCCI, FELICIA, PROTO, VINCENZO, ROMANO, RAFFAELE, VARRICCHIO, MARIA LUISA   +4 more
core  

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Influence of hight - fat diets with different fatty-acid composition on rat periodontal condition

Journal of Education, Health and Sport, 2017
Aim: Determine the effect of high-fat diets (HFD) with different fatty acid composition on the condition of the gums of rats. Materials and Methods: 4 types of edible fats were used: sunflower oil ( main acid - linoleic), olive oil (main acid -oleic ...
A. V. Markov
doaj   +3 more sources

Antagonism Between Saturated and Unsaturated Fatty Acids in ROS Mediated Lipotoxicity in Rat Insulin-Producing Cells

Cellular Physiology and Biochemistry, 2015
Background/Aims: Elevated levels of non-esterified fatty acids (NEFAs) are under suspicion to mediate β-cell dysfunction and β-cell loss in type 2 diabetes, a phenomenon known as lipotoxicity.
Wiebke Gehrmann, Wiebke Würdemann, Thomas Plötz, Anne Jörns, Sigurd Lenzen, Matthias Elsner   +5 more
doaj   +1 more source

Unlocking the in vitroanti- inflammatory and antidiabetic potential of Polygonum maritimum [PDF]

, 2017
Context: Several Polygonum species (Polygonaceae) are used in traditional medicine in Asia, Europe and Africa to treat inflammation and diabetes. Objective: Evaluate the in vitro antioxidant, anti-inflammatory and antidiabetic potential of methanol and ...
Alice Martins, Amélia P. Rauter, Andreia Lopes, Bhandari U, Huang X, José M. F. Nogueira, João Varela, Kilinc M, Luísa Barreira, Luísa Custódio, Maria João Rodrigues, Marta Oliveira, Muriach M, Nishishiro M, Nuno R. Neng, Shai LJ, Veerasamy R   +16 more
core   +1 more source