Results 91 to 100 of about 34,702 (278)

Palmitoylation and depalmitoylation defects [PDF]

Journal of Inherited Metabolic Disease, 2014
AbstractPalmitoylation describes the enzymatic attachment of a 16‐carbon atom fatty acid to a target protein. Such lipidation events occur in all eukaryotes and can be of reversible (S‐palmitoylation) or irreversible (N‐palmitoylation) nature. In particular S‐palmitoylation is dynamically regulated by two opposing types of enzymes which add (palmitoyl ...
openaire   +4 more sources

Cutting‐edge advances in bicyclic peptide‐based radiotracers for cancer imaging and theranostics

VIEW, EarlyView.
Abstract Along with successful clinical approval of radiopharmaceuticals targeting somatostatin receptor subtype 2 and prostate‐specific membrane antigen, peptide‐based radiotracers have garnered the increasing attention in cancer imaging and theranostics. As a newly emerging targeting ligand in recent years, bicyclic peptides have demonstrated immense
Hengyi Ou, Xiaobo Wang, Fei Kang
wiley   +1 more source

Maternally supplied S-acyl-transferase is required for crystalloid organelle formation and transmission of the malaria parasite. [PDF]

, 2016
Transmission of the malaria parasite from the mammalian host to the mosquito vector requires the formation of adequately adapted parasite forms and stage-specific organelles.
Avramut, M Cristina, Chevalley-Maurel, Séverine, Dessens, Johannes T, Duarte, Neuza, Franke-Fayard, Blandine, Frischknecht, Friedrich, Janse, Chris J, Kehrer, Jessica, Koster, Abraham J, Mair, Gunnar R, Ramesar, Jai, Santos, Jorge M   +11 more
core   +2 more sources

Advances in targeting protein S-palmitoylation in tumor immunity and therapy

Frontiers in Oncology
S-palmitoylation is a reversible and dynamic post-translational modification of proteins. A palmitoyl group is covalently attached to a cysteine residue of the protein by a thioester link.
Miaomiao Han, Miaomiao Han, Yuanhao Lv, Yuanhao Lv, Yiyang Chen, Zhaoyi Li, Jiaqi Tian, Hongyan Zhou, Yunlong Wang, Wei Su, Wei Su, Jiateng Zhong, Jiateng Zhong, Jiateng Zhong   +13 more
doaj   +1 more source

Palmitoylation of virus proteins [PDF]

Biology of the Cell, 2012
AbstractThe article summarises the results of more than 30 years of research on palmitoylation (S‐acylation) of viral proteins, the post‐translational attachment of fatty acids to cysteine residues of integral and peripheral membrane proteins. Analysing viral proteins is not only important to characterise the cellular pathogens but also instrumental to
openaire   +2 more sources

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Gephyrin palmitoylation and oligomerization in synaptic plasticity, membrane recruitment and proteostasis [PDF]

, 2012
Efficient signal transmission in the central nervous system is essential for higher brain functions. Inhibitory signaling in the brain primarily takes place at GABAergic (γ-aminobutyric acid) synapses and balances the activity of excitatory synapses ...
Dejanovic, Borislav
core  

Biomimetic soft matter [PDF]

, 2011
Biomaterials are often soft materials. There is now growing interest in designing, synthesizing and characterising soft materials that mimic the properties of biological materials such as tissue, proteins, DNA or cells. Research on biomimetic soft matter
Hamley, Ian
core   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Temporal and protein-specific S-palmitoylation supports synaptic and neural network plasticity

Cellular and Molecular Life Sciences
Background Synaptic plasticity, a fundamental process underlying learning and memory, depends on activity-driven changes in neural connectivity. S-palmitoylation, a reversible post-translational lipid modification, modulates synaptic protein function by ...
Agata Pytyś, Rabia Ijaz, Anna Buszka, Jacek Miłek, Izabela Figiel, Patrycja Wardaszka-Pianka, Matylda Roszkowska, Natalia Mierzwa, Adam Wojtas, Eli Kerstein, Remigiusz Serwa, Katarzyna Kalita, Rhonda Dzakpasu, Magdalena Dziembowska, Jakub Włodarczyk, Tomasz Wójtowicz   +15 more
doaj   +1 more source