Results 111 to 120 of about 17,841 (206)

Current Perspectives on STING Agonists for Anticancer Drug Development

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
The molecular structures of STING agonists play a decisive role in regulating the STING pathway. Their distinct scaffolds and functional groups orchestrate receptor binding, conformational activation, and the subsequent immune response. ABSTRACT The cyclic GMP‐AMP (cGAS) synthase and stimulator of interferon genes signaling pathway plays a central role
Dilay Kahvecioglu Cicek
wiley   +1 more source

Membrane‐type I metalloproteinase (MT1‐MMP): A key modifier of extracellular matrix microenvironment

The FEBS Journal, Volume 293, Issue 13, Page 4085-4097, July 2026.
MT1‐MMP: A cellular microenvironment modifier. MT1‐MMP is a major cellular microenvironment modifier, maintaining collagen homeostasis by degrading excess collagen (A), creating a migration path in motile cells such as cancer cells (B), modulating local microenvironmental signaling by cleaving transmembrane receptors (C), and destroying tissue ...
Yoshifumi Itoh, Masaki Inada
wiley   +1 more source

From Synapses to Circuits, the Role of KIBRA and the WWC Family in Adaptive Brain Function

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
KIBRA (WWC1) has been the subject of scientific interest since its initial association with nonpathological variation in human memory performance. This review discusses subsequent work in animal models demonstrating that KIBRA supports memory function.
Lenora J. Volk
wiley   +1 more source

Unconventional Protein Secretion in the Central Nervous System: Mechanisms and Roles in Physiology and Disease

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Neurons and glia secrete and respond to numerous proteins that are released independently of the conventional ER–Golgi pathway. These unconventionally secreted proteins exert diverse pathogenic, immunomodulatory, and neuroprotective functions and are therefore implicated in multiple neurodegenerative diseases. They originate in the cytosol and exit the
Steven A. Krauklis, Sevnur Kömürlü Keçeli, Edward M. Campbell, Prabhodh S. Abbineni   +3 more
wiley   +1 more source

<i>S</i>-Palmitoylation in Health and Disease. [PDF]

Biochemistry
Wong W, Hu M, Isaacson RL.
europepmc   +1 more source

miR-130a-3p regulates the occurrence and progression of lung squamous cell carcinoma by activating ZDHHC5 and immune cell-related pathways. [PDF]

Medicine (Baltimore)
Li W, Xia B, Deng S.
europepmc   +1 more source

LAT Palmitoylation [PDF]

Immunity, 1998
Zhang, Weiguo, Trible, Ronald P, Samelson, Lawrence E   +2 more
openaire   +1 more source

AKT-mediated phosphorylation of ZDHHC5 promotes NOD1 palmitoylation and innate immune signaling. [PDF]

Front Immunol
Mi S, Zhu Y, Li Q, Wang X, Guo X, Chen Y.   +5 more
europepmc   +1 more source

Spatial control of NLRP3 inflammasome assembly by membrane lipid composition. [PDF]

Commun Biol
Anand PK, Aljadeed NM.
europepmc   +1 more source

The Activation of ARF1 Is Dynamically Regulated by its Palmitoylation. [PDF]

Mol Cell Proteomics
Zhu J, Li W, Ji M, Chang X, Cao Y, Gao J, Qi S, Kong E.   +7 more
europepmc   +1 more source