Results 91 to 100 of about 20,725 (233)
Signal Transduction and Targeted TherapyThe downregulation of Cadm4 (Cell adhesion molecular 4) is a prominent feature in demyelination diseases, yet, the underlying molecular mechanism remains elusive.
Yanli Chang +15 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.This review highlights biocatalytic prenylation as a versatile strategy for tailoring the functional properties of peptides and proteins. By comparing branched isoprenoids with linear lipids, we illustrate how specific prenyl architectures modulate the behaviors of lipidated proteins within membrane environments.
Daisuke Fujinami +2 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira +12 more
wiley +1 more source
Palmitoylation of Platelet Proteins
Platelets, 1994 Palmitoylation as incorporation of [(3)H] palmitic acid into proteins occurred in platelets as in other cell systems. The linkage of palmitic acid to platelet proteins was stable to SDS and organic solvents but was sensitive to hydroxylamine, consistent with oxyester or thioester bond(s). Non-reduced SDS PAGE analysis revealed that the most prominantly
openaire +2 more sources
Traceable Traceless Delivery Tags
Helvetica Chimica Acta, EarlyView.ABSTRACT This study elaborates on traceless tags for the thiol‐mediated uptake (TMU) of amine‐containing substrates of interest (SOIs). Traceless tags typically contain linkers that can be enzymatically cleaved to trigger the release of SOIs in their native form.
Julia Moreno +5 more
wiley +1 more source
Structural and functional investigation of the cytoplasmic domain of the Fas death receptor
, 2015 Activation of the transmembrane death receptor Fas (CD95/APO-1) by a membrane bound ligand (FasL/CD95L) activates the extrinsic pathway of apoptosis. Intracellular Fas death domains (DDs) are induced to oligomerise enabling binding to the adaptor protein
Wildsmith, GC
core
Advances in targeting protein S-palmitoylation in tumor immunity and therapy
Frontiers in OncologyS-palmitoylation is a reversible and dynamic post-translational modification of proteins. A palmitoyl group is covalently attached to a cysteine residue of the protein by a thioester link.
Miaomiao Han +13 more
doaj +1 more source
International Journal of Cancer, EarlyView.MEF2B and BCL6 have established functions in germinal center B‐cell biology and lymphomagenesis. The mechanism of MEF2B deregulation and its significance for cell survival in Burkitt lymphoma however remain unclear. This study highlights MEF2B as a crucial transcription factor in Burkitt lymphoma and suggests ZDHHC11 as an upstream regulator of MEF2B ...
Lotteke J. Y. M. Ziel‐Swier +12 more
wiley +1 more source
The effect of palmitoylation on biological functions of proteins [PDF]
, 2017 Palmitoylation is lipid post-translational modification of proteins. It is one of the most common protein lipidations in eukaryotic cells. Unlike other lipid post-translational modifications, palmitoylation is reversible.
Frýdová, Tereza
core