Results 121 to 130 of about 34,702 (278)
Post‐Translational Modifications in Animal Circadian Clocks
Advanced Science, Volume 13, Issue 16, 18 March 2026.Circadian clocks coordinate physiology with daily environmental cycles through conserved transcriptional–translational feedback loops. This review summarizes how post‐translational modifications fine‐tune clock function, highlights the evolutionary convergence of circadian timekeeping in Drosophila and mammals, and emphasizes the central of these ...
Xianhui Liu, Yong Zhang
wiley +1 more source
PLoS ONE, 2011 Protease-activated receptor-2 (PAR2) is a G protein coupled receptor (GPCR) activated by proteolytic cleavage of its amino terminal domain by trypsin-like serine proteases. This irreversible activation mechanism leads to rapid receptor desensitization by
Mark N Adams +4 more
doaj +1 more source
Cell Reports, 2018 Summary: Ca2+-permeable AMPA-type glutamate receptors (CP-AMPARs) containing GluA1 but lacking GluA2 subunits contribute to multiple forms of synaptic plasticity, including long-term potentiation (LTP), but mechanisms regulating CP-AMPARs are poorly ...
Alicia M. Purkey +6 more
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Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex [PDF]
, 2014 Gregory J Fredericks +6 more
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Palmitoylation of Platelet Proteins
Platelets, 1994 Palmitoylation as incorporation of [(3)H] palmitic acid into proteins occurred in platelets as in other cell systems. The linkage of palmitic acid to platelet proteins was stable to SDS and organic solvents but was sensitive to hydroxylamine, consistent with oxyester or thioester bond(s). Non-reduced SDS PAGE analysis revealed that the most prominantly
openaire +2 more sources
BioEssays, Volume 48, Issue 3, March 2026.NLRP3, a cytosolic innate immune sensor, responds to diverse activators that perturb cellular homeostasis. These disturbances generate molecular scaffolds that, through binding partners such as nucleic acids, lipids, and proteins, recruit and concentrate NLRP3. Scaffold‐mediated NLRP3 clustering promotes NLRP3 inflammasome assembly.
Elvira Boršić‐Mlinarič +1 more
wiley +1 more source
Medicine PlusProtein palmitoylation modification is a key lipidated post-translational modification that dynamically regulates protein function, subcellular localization, and signaling pathways in eukaryotic cells, with important implications for the onset and ...
Zhenteng Liu +5 more
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CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.In a kainic acid‐induced mouse model of epilepsy, upregulation of HSDL2 in the hippocampus prolonged seizure latency, increased the membrane expression of PSD95, and enhanced its phosphorylation. Concurrently, HSDL2 attenuated the interaction between PSD95 and the NMDAR subunits GluN2A/GluN2B, thereby suppressing NMDAR overactivation, reducing ...
Yan Xia +5 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.The acyl‐CoA synthetase long‐chain (ACSL) family consists of five members, which exhibit a synergistic effect in promoting tumour lipid metabolism for energy supply. Specifically, ACSL3 and ACSL4 have antagonistic effects on the mechanisms related to ferroptosis in tumour cells.
Haocai Li +6 more
wiley +1 more source
Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis
Nature CommunicationsS-palmitoylation is a reversible and widespread post-translational modification, but its role in the regulation of ferroptosis has been poorly understood. Here, we elucidate that GPX4, an essential regulator of ferroptosis, is reversibly palmitoylated on
Bin Huang +10 more
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