Results 141 to 150 of about 34,702 (278)
The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities
MedComm, Volume 7, Issue 3, March 2026.Diverse diseases converge on NLRP3. We depict a discovery‐to‐clinic track: high‐throughput/phenotypic screens, structure‐guided design, and modality innovation (allosteric inhibitors, interface blockers, degraders) deliver third‐generation, disease‐tailored NLRP3 control.
Chan Zou +5 more
wiley +1 more source
RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang +6 more
wiley +1 more source
Prokaryotic PfaB is a terminal acyltransferase that determines the final PUFA product
Protein Science, Volume 35, Issue 3, March 2026.Abstract Omega‐3 polyunsaturated fatty acids (PUFAs) are essential for human health due to their numerous beneficial biological properties. These compounds are synthesized in marine bacteria and eukaryotic microalgae by PUFA megasynthases (Pfas), which are evolutionarily related to fatty acid synthases (FAS) and polyketide synthases (PKS). In FAS, PKS,
Nahuel Lofeudo +5 more
wiley +1 more source
A palmitoylation switch mechanism regulates Rac1 function and membrane organization [PDF]
, 2011 Inmaculada Navarro‐Lérida +6 more
openalex +1 more source
Evaluation of Tetraspanins in Extracellular Vesicle Bioengineering
Small Science, Volume 6, Issue 3, March 2026.CRISPR‐mediated knockout of CD9, CD63, and CD81 demonstrates that simultaneous deletion reduces extracellular vesicle (EV) production, whereas single knockouts have minimal effect. Reintroduction of tetraspanin‐reporter fusion constructs significantly enhance engineered EV yield (50‐70%) compared to wild‐type cells. These findings highlight tetraspanin
Doste R. Mamand +12 more
wiley +1 more source
Artificial lipidation of proteins and peptides: from mechanism to clinical applications
The FEBS Journal, Volume 293, Issue 5, Page 1269-1284, March 2026.Artificial lipidation transforms protein and peptide therapeutics by attaching fatty acid chains through reversible or permanent chemical strategies. This biomimetic approach delivers four key therapeutic advantages: extended circulation times (enabling weekly instead of daily dosing), alternative administration routes including oral delivery, precise ...
Jiaming Mu, Emily Vong, Sheiliza Carmali
wiley +1 more source
Protein palmitoylation: biological functions, disease, and therapeutic targets
MedCommProtein palmitoylation, a reversible post‐translational lipid modification, is catalyzed by the ZDHHC family of palmitoyltransferases and reversed by several acyl protein thioesterases, regulating protein localization, accumulation, secretion, and ...
Yan‐Ran Qian +2 more
doaj +1 more source
Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics
The FEBS Journal, Volume 293, Issue 5, Page 1433-1458, March 2026.NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang +5 more
wiley +1 more source
Cellular & Molecular Biology LettersPalmitoylation is a type of lipid modification that plays an important role in various aspects of neuronal function. Over the past few decades, several studies have shown that the palmitoylation of synaptic proteins is involved in neurotransmission and ...
Jiaying Peng +2 more
doaj +1 more source