Results 141 to 150 of about 39,498 (303)

Palmitoylation regulates myelination by modulating the ZDHHC3-Cadm4 axis in the central nervous system

Signal Transduction and Targeted Therapy
The downregulation of Cadm4 (Cell adhesion molecular 4) is a prominent feature in demyelination diseases, yet, the underlying molecular mechanism remains elusive.
Yanli Chang, Jiangli Zhu, Xiaopeng Li, Yi Deng, Birou Lai, Yidan Ma, Jia Tong, Huicong Liu, Juanjuan Li, Chenyu Yang, Qiao Chen, Chengbiao Lu, Yinming Liang, Shiqian Qi, Xiaoning Wang, Eryan Kong   +15 more
doaj   +1 more source

The Unconventional Role of ABHD17A in Increasing the S-Palmitoylation and Antiviral Activity of IFITM1 by Downregulating ABHD16A

Biomolecules
The broad-spectrum antiviral functions of interferon-inducible transmembrane 1 (IFITM1) rely on S-palmitoylation post-translational modification.
Xuemeng Shi, Shuaiwu Chen, Mingyang Liu, Yali Fan, Xin Wen, Jingyi Wang, Xiaoling Li, Huimin Liu, Lin Mao, Li Yu, Yuxin Hu, Jun Xu   +11 more
doaj   +1 more source

The Plasmodium alveolin IMC1a is stabilised by its terminal cysteine motifs and facilitates sporozoite morphogenesis and infectivity in a dose-dependent manner. [PDF]

, 2016
Apicomplexan parasites possess a unique cortical cytoskeleton structure composed of intermediate filaments. Its building blocks are provided by a conserved family of proteins named alveolins.
Al-Khattaf, Fatimah S, Dessens, Johannes T, El-Houderi, Amira, Tremp, Annie Z   +3 more
core   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

Insights into a Machine Learning-Based Palmitoylation-Related Gene Model for Predicting the Prognosis and Treatment Response of Breast Cancer Patients

Technology in Cancer Research & Treatment
Background Breast cancer is a prevalent public health concern affecting numerous women globally and is associated with palmitoylation, a post-translational protein modification.
Hongxia Zhu MS, Haihong Hu MS, Bo Hao BD, Wendi Zhan MS, Ting Yan MS, Jingdi Zhang MS, Siyu Wang MS, Hongjuan Hu MS, Taolan Zhang MD   +8 more
doaj   +1 more source

Gephyrin palmitoylation and oligomerization in synaptic plasticity, membrane recruitment and proteostasis [PDF]

, 2012
Efficient signal transmission in the central nervous system is essential for higher brain functions. Inhibitory signaling in the brain primarily takes place at GABAergic (γ-aminobutyric acid) synapses and balances the activity of excitatory synapses ...
Dejanovic, Borislav
core  

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Dysfunctional Decidual CD4+T Cells Induce Recurrent Pregnancy Loss via Palmitoylation‐Dependent Tim‐3 Lysosomal Sorting and Degradation

Advanced Science
Palmitoylation is a fully reversible post‐translational modification that regulates the functions of various proteins. While its dysregulation has been implicated in numerous pathological processes, there has been scarce researches on palmitoylation ...
Liyuan Cui, Xinhang Meng, Yujie Luo, Jinfeng Qian, Fengrun Sun, Mingke Qiu, Songcun Wang   +6 more
doaj   +1 more source

Semliki Forest viiruse replikaasivalgu nsP1 uurimine [PDF]

, 2013
Väitekirja elektrooniline versioon ei sisalda publikatsioone.Semliki Forest viirus kuulub alfaviiruste perekonda sugukonnas Togaviridae. Alfaviirused on olulised patogeenid ning põhjustavad erinevaid vaevusi nii loomadele kui ka inimestele.
Karo-Astover, Liis
core  

A palmitoylation switch mechanism regulates Rac1 function and membrane organization [PDF]

, 2011
Inmaculada Navarro‐Lérida, Sara Sánchez-Perales, Marı́a Calvo, Carles Rentero, Yi Zheng, Carlos Enrich, Miguel Á. del Pozo   +6 more
openalex   +1 more source