Results 81 to 90 of about 26,467 (310)
DNA microarrays with PAMAM dendritic linker systems [PDF]
Nucleic Acids Research, 2002 The DNA microarray-based analysis of single nucleotide polymorphisms (SNPs) is important for the correlation of genetic variations and individual phenotypes, and for locating disease-causing genes. To facilitate the development of surfaces suitable for immobilization of oligonucleotides, we report here a novel method for the surface immobilization of ...
Rüdiger Benters +4 more
openaire +3 more sources
Molecular insights into the physics of poly(amidoamine)-dendrimer-based supercapacitors [PDF]
arXiv, 2022 Increasing the energy density in electric double layer capacitors (EDLCs), also known as supercapacitors, remains an active area of research. Specifically, there is a need to design and discover electrode and electrolyte materials with enhanced electrochemical storage capacity.
arxiv
Practical computational toolkits for dendrimers and dendrons structure design [PDF]
, 2017 Dendrimers and dendrons offer an excellent platform for developing novel drug delivery systems and medicines. The rational design and further development of these repetitively branched systems are restricted by difficulties in scalable synthesis and ...
A Kwok +52 more
core +2 more sources
Functional Dendrimer Nanogels for DNA Delivery and Gene Therapy of Tumors
Angewandte Chemie, EarlyView.Dendrimer nanogels are designed by emulsion‐free method, endowing them with dual‐active groups, o‐hydroxyl amine, temperature‐responsiveness, polyampholyte property, and self‐triggered aminolysis. With these unique characters, dendrimer nanogels display high gene transfection and therapeutic efficacies with low side effects, thus solving the dilemma ...
Xin Li +7 more
wiley +2 more sources
Molecules, 2018 Clinical applications of many small molecules are limited due to poor solubility and lack of controlled release besides lack of other desirable properties.
Daniel M. Shadrack +4 more
doaj +1 more source
The Structure of PAMAM DAB-dendr(NH2)4 – the First Crystal Structure of a PAMAM-Dendrimer [PDF]
, 2020 The first crystal structure of an amino terminated PAMAM-dendrimer (DABdendr(NH2)4) is reported. The structure features a compact dendrimer conformation without voids, held together by intermolecular hydrogen bonds between ...
Jesper Bendix, Joern Christensen
openaire +1 more source
Advanced Healthcare Materials, EarlyView.Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray +2 more
wiley +1 more source
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
Advanced Healthcare Materials, EarlyView.The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq +4 more
wiley +1 more source
Nanomaterials, 2019 Dentin hypersensitivity (DH) is one of the most common clinical conditions usually associated with exposed dentinal surfaces. In this study, we identified the effectiveness of poly(amidoamine) (PAMAM) dendrimer-coated mesoporous bioactive glass ...
Jungin Bae +8 more
doaj +1 more source
Bolstering cholesteryl ester hydrolysis in liver: A hepatocyte-targeting gene delivery strategy for potential alleviation of atherosclerosis [PDF]
, 2017 Current atherosclerosis treatment strategies primarily focus on limiting further cholesteryl esters (CE) accumulation by reducing endogenous synthesis of cholesterol in the liver.
Ghosh, Shobha +5 more
core +2 more sources