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TOC1 supresses PAMP-triggered immunity in Arabidopsis
Fraser OJP, Spoel SH, van Ooijen G.
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Sensing, Presenting, and Regulating PAMPS
2008Recognition of microbial infection and initiation of immune responses are controlled by multiple mechanisms. Toll-like receptors (TLRs) are key components of the innate immune system that detect microbial infection. TLR activation helps to eliminate the invading pathogens, coordinate systemic defenses, and initiate adaptive immune responses.
de Diego, J., Gerold, G., Zychlinsky, A.
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Is the Cytoskeleton an Intracellular Receptor for Adrenomedullin and PAMP?
Current Protein & Peptide Science, 2013Classical transmembrane receptors have been described for both adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP). Through interactions with these membrane receptors, AM and PAMP exert a variety of endocrine, paracrine, and autocrine functions.
Ignacio M, Larráyoz +4 more
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Science Signaling, 2015
A peptide inhibitor specifically blocks activation of the receptor TLR4 by damage-associated, but not pathogen-associated, molecular patterns.
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A peptide inhibitor specifically blocks activation of the receptor TLR4 by damage-associated, but not pathogen-associated, molecular patterns.
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Immunological Mechanism and Clinical Application of PAMP Adjuvants
Recent Patents on Anti-Cancer Drug Discovery, 2021Background:The host innate immune system can recognize Pathogen-Associated Molecular Patterns (PAMPs) through Pattern Recognition Receptors (PRRs), thereby initiating innate immune responses and subsequent adaptive immune responses. PAMPs can be developed as a vaccine adjuvant for modulating and optimizing antigen-specific immune responses, especially ...
Yu Yan, Dan Yao, Xiaoyu Li
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DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation
Annual Review of Pathology: Mechanisms of Disease, 2020Recognizing the importance of leukocyte trafficking in inflammation led to some therapeutic breakthroughs. However, many inflammatory pathologies remain without specific therapy. This review discusses leukocytes in the context of sterile inflammation, a process caused by sterile (non-microbial) molecules, comprising damage-associated molecular ...
Zindel, Joel, Kubes, Paul
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Nihon rinsho. Japanese journal of clinical medicine, 1997
"Adrenomedullin (AM)" is a novel hypotensive peptide which was discovered in human pheochromocytoma by monitoring the elevating activity of platelet cAMP. In addition, a novel 20 residues hypotensive peptide, termed "proadrenomedullin N-terminal 20 peptide" (PAMP) is processed from proadrenomedullin. By RNA blot analysis, AM mRNA was found to be highly
K, Kitamura, T, Eto
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"Adrenomedullin (AM)" is a novel hypotensive peptide which was discovered in human pheochromocytoma by monitoring the elevating activity of platelet cAMP. In addition, a novel 20 residues hypotensive peptide, termed "proadrenomedullin N-terminal 20 peptide" (PAMP) is processed from proadrenomedullin. By RNA blot analysis, AM mRNA was found to be highly
K, Kitamura, T, Eto
openaire +1 more source
Adrenomedullin and PAMP: Discovery, structures, and cardiovascular functions
Microscopy Research and Technique, 2002AbstractWe discovered adrenomedullin (AM) from human pheochromocytoma tissue by monitoring the elevating activity of intracellular cyclic AMP (cAMP) in rat platelets in 1993. Since the discovery of AM, it has attracted intense interest from cardiovascular researchers because AM elicits multiple biological activities, including a potent and powerful ...
Kazuo, Kitamura +2 more
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