Results 51 to 60 of about 27,901 (286)

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Pathogen-associated molecular patterns alter molecular clock gene expression in mouse splenocytes. [PDF]

PLoS ONE, 2017
Circadian rhythms are endogenous 24-h oscillations that influence a multitude of physiological processes. The pathogen-associated molecular pattern (PAMP), lipopolysaccharide, has been shown to modify the circadian molecular clock.
Adam C Silver
doaj   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Functional Fibers in Soft Robotics: Advances in Material, Structural, and Systemic Tactics

Advanced Robotics Research, EarlyView.
Fiber‐form robotic systems offer a scalable pathway toward embodied intelligence in soft robotics. This review surveys functional fibers as material, structural, and systemic elements, highlighting advances in responsive materials, architectural programing, and fabrication strategies.
Joonhee Won, Jaehyun Jang, Hyeonseo Kim, Inyoung Choi, Steve Park, Seongjun Park   +5 more
wiley   +1 more source

Brucella abortus RNA does not polarize macrophages to a particular profile but interferes with M1 polarization.

PLoS Neglected Tropical Diseases, 2022
Monocytes and macrophages play a central role in chronic brucellosis. Brucella abortus (Ba) is an intracellular pathogen that survives inside these cells.
Agustina Serafino, José L Marin Franco, Mariano Maio, Aldana Trotta, Melanie Genoula, Luis A Castillo, Federico Birnberg Weiss, José R Pittaluga, Luciana Balboa, Paula Barrionuevo, M Ayelén Milillo   +10 more
doaj   +1 more source

Superior Efficacy of Apathogenic Genotype I (V4) over Lentogenic Genotype II (LaSota) Live Vaccines against Newcastle Disease Virus Genotype VII.1.1 in Pathogen-Associated Molecular Pattern-H9N2 Vaccinated Broiler Chickens

Vaccines, 2023
A comparison of the efficacy of apathogenic genotype I (V4) and lentogenic genotype II (LaSota) strains of live Newcastle disease virus (NDV) vaccines was performed following vaccination with pathogen-associated molecular pattern (PAMP) H9N2 avian ...
Ahmed Elbestawy, Hany Ellakany, Mahmoud Sedeik, Ahmed Gado, Mervat Abdel-Latif, Ahmed Noreldin, Ahmed Orabi, Ismail Radwan, Wafaa Abd El-Ghany   +8 more
doaj   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

SAA1 sees PAMP in the mite [PDF]

Science, 2020
Immunology If you wake up with streaming eyes and nose, it could be that you are allergic to the house dust mite. The molecular mechanisms through which the molecular patterns of such organisms initiate allergic responses is poorly understood. Smole et al .
openaire   +1 more source

Identification of 118 Arabidopsis Transcription Factor and 30 Ubiquitin-Ligase Genes Responding to Chitin, a Plant-Defense Elicitor

Molecular Plant-Microbe Interactions, 2007
Chitin, found in the cell walls of true fungi and the exoskeleton of insects and nematodes, is a well-established elicitor of plant defense responses.
Marc Libault, Jinrong Wan, Tomasz Czechowski, Michael Udvardi, Gary Stacey   +4 more
doaj   +1 more source

Extracellular vesicles from human plasma dampen inflammation and promote tissue repair functions in macrophages

Journal of Extracellular Vesicles, 2023
Although inflammation is a vital defence response to infection, if left uncontrolled, it can lead to pathology. Macrophages are critical players both in driving the inflammatory response and in the subsequent events required for restoring tissue ...
Alan M. Adamczyk, María Luz Leicaj, Martina Paula Fabiano, Gonzalo Cabrerizo, Nadia Bannoud, Diego O. Croci, Kenneth W. Witwer, Federico Remes Lenicov, Matías Ostrowski, Paula Soledad Pérez   +9 more
doaj   +1 more source