Results 41 to 50 of about 23,370 (263)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Brucella abortus RNA does not polarize macrophages to a particular profile but interferes with M1 polarization.

PLoS Neglected Tropical Diseases, 2022
Monocytes and macrophages play a central role in chronic brucellosis. Brucella abortus (Ba) is an intracellular pathogen that survives inside these cells.
Agustina Serafino, José L Marin Franco, Mariano Maio, Aldana Trotta, Melanie Genoula, Luis A Castillo, Federico Birnberg Weiss, José R Pittaluga, Luciana Balboa, Paula Barrionuevo, M Ayelén Milillo   +10 more
doaj   +1 more source

Superior Efficacy of Apathogenic Genotype I (V4) over Lentogenic Genotype II (LaSota) Live Vaccines against Newcastle Disease Virus Genotype VII.1.1 in Pathogen-Associated Molecular Pattern-H9N2 Vaccinated Broiler Chickens

Vaccines, 2023
A comparison of the efficacy of apathogenic genotype I (V4) and lentogenic genotype II (LaSota) strains of live Newcastle disease virus (NDV) vaccines was performed following vaccination with pathogen-associated molecular pattern (PAMP) H9N2 avian ...
Ahmed Elbestawy, Hany Ellakany, Mahmoud Sedeik, Ahmed Gado, Mervat Abdel-Latif, Ahmed Noreldin, Ahmed Orabi, Ismail Radwan, Wafaa Abd El-Ghany   +8 more
doaj   +1 more source

SAA1 sees PAMP in the mite [PDF]

Science, 2020
Immunology If you wake up with streaming eyes and nose, it could be that you are allergic to the house dust mite. The molecular mechanisms through which the molecular patterns of such organisms initiate allergic responses is poorly understood. Smole et al .
openaire   +1 more source

Using PAMPs and DAMPs as adjuvants in cancer vaccines

Human Vaccines & Immunotherapeutics, 2021
Immunotherapy for cancer has attracted considerable attention. As one of the immunotherapeutics, tumor vaccines exert great potential for cancer immunotherapy. The most important components in tumor vaccines are antigens and adjuvants, which determine the therapeutic safety and efficacy, respectively.
Huanyou Sun, Wenwen Hu, Yinan Yan, Zichun Zhang, Yuxin Chen, Xuefan Yao, Ling Teng, Xinyuan Wang, Dafei Chai, Junnian Zheng, Gang Wang   +10 more
openaire   +3 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Identification of 118 Arabidopsis Transcription Factor and 30 Ubiquitin-Ligase Genes Responding to Chitin, a Plant-Defense Elicitor

Molecular Plant-Microbe Interactions, 2007
Chitin, found in the cell walls of true fungi and the exoskeleton of insects and nematodes, is a well-established elicitor of plant defense responses.
Marc Libault, Jinrong Wan, Tomasz Czechowski, Michael Udvardi, Gary Stacey   +4 more
doaj   +1 more source

Extracellular vesicles from human plasma dampen inflammation and promote tissue repair functions in macrophages

Journal of Extracellular Vesicles, 2023
Although inflammation is a vital defence response to infection, if left uncontrolled, it can lead to pathology. Macrophages are critical players both in driving the inflammatory response and in the subsequent events required for restoring tissue ...
Alan M. Adamczyk, María Luz Leicaj, Martina Paula Fabiano, Gonzalo Cabrerizo, Nadia Bannoud, Diego O. Croci, Kenneth W. Witwer, Federico Remes Lenicov, Matías Ostrowski, Paula Soledad Pérez   +9 more
doaj   +1 more source

TMT-based quantitative proteome data of MSP1 overexpressed rice

Data in Brief, 2023
Data reported here is associated with the article entitled “TMT-based quantitative membrane proteomics identified pattern recognition receptors (PRRs) potentially involved in the perception of MSP1 in rice leaves” [1].
Cheol Woo Min, Jeong Woo Jang, Gi Hyun Lee, Ravi Gupta, Sun Tae Kim   +4 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source