Results 41 to 50 of about 27,901 (286)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

PAMPs and Host Immune Response in Cryptococcal Infection

Medical Mycology Journal, 2022
Cryptococcus spp. are yeast-type opportunistic fungal pathogens with thick polysaccharide capsules that infect the lungs via airborne routes and frequently cause fatal meningoencephalitis. The cellular immune mechanism plays a central role in controlling cryptococcal infection and is critically regulated by Th1-Th2 immune balance.
Sato, Ko, Kawakami, Kazuyoshi
openaire   +2 more sources

Antioxidant and Hepatoprotective Effects of Polyphenols in Leaves of Pamp

Natural Product Communications, 2007
The leaves of Artemisia princeps Pamp have been used for tea and food in Japan. The polyphenols of the leaves have inhibitory effects against lipid peroxidation and protein fragmentation by free radicals in vitro and an inhibitory effect on galactosamine
Shizuo Toda
doaj   +1 more source

The Lamin-Like LITTLE NUCLEI 1 (LINC1) Regulates Pattern-Triggered Immunity and Jasmonic Acid Signaling

Frontiers in Plant Science, 2020
Pathogen-associated molecular pattern (PAMP) recognition occurs by plasma membrane located receptors that induce among other processes nuclear gene expression.
Mai Jarad, Kiruthiga Mariappan, Marilia Almeida-Trapp, Michael Florian Mette, Axel Mithöfer, Naganand Rayapuram, Heribert Hirt   +6 more
doaj   +1 more source

Pelvic obliquity and measurement of hip displacement in children with cerebral palsy

Acta Orthopaedica, 2018
Background and purpose — Pelvic obliquity, common in individuals with cerebral palsy (CP), changes the muscle force vector on the hip joint and probably affects the risk of hip dislocation. We evaluated a new method for measurement of hip displacement in
Gunnar Hägglund, Mikael Goldring, Maria Hermanson, Elisabet Rodby-Bousquet   +3 more
doaj   +1 more source

Proadrenomedullin N-Terminal 20 Peptide (PAMP) immunoreactivity in vertebrate juxtaglomerular granular cells identified by both light and electron microscopy

, 1999
The gene for adrenomedullin (AM), a multifunctional peptide hormone, is expressed in mammalian renal tissue and has been shown to stimulate renin release. The exact cell source of this peptide and its gene-related partner, proadrenomedullin N-terminal 20
Cuttita, Frank, Montuenga, Luis, López, José, Cuesta Rubio, Natalia   +3 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Microbial RNA, the New PAMP of Many Faces

Frontiers in Tropical Diseases, 2022
Traditionally, pathogen-associated molecular patterns (PAMPs) were described as structural molecular motifs shared by different classes of microorganisms. However, it was later discovered that the innate immune system is also capable of distinguishing metabolically active microbes through the detection of a special class of viability-associated PAMPs ...
M. Ayelén Milillo, Lis N. Velásquez, Paula Barrionuevo   +2 more
openaire   +2 more sources

Mediator subunit MED19 modulates elf18-induced PR1 expression via TGA transcription factors

Plant Signaling & Behavior
The Mediator complex bridges transcription factors and RNA polymerase II to regulate gene expression during plant immune responses. We previously demonstrated that the Mediator subunit MED19a modulates PATHOGEN-RELATED 1 (PR1) expression through ...
Taeyoung Um, Gang-Seob Lee, Jun Sung Seo
doaj   +1 more source