A new paradigm: 46 structural cell types function as environment-supporting innate immune cells, with endothelial and vascular smooth muscle cells as key prototypes. [PDF]
Inew MedABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Liu J +22 more
europepmc +2 more sources
How does an RNA selfie work? EV-associated RNA in innate immunity as self or danger
Journal of Extracellular Vesicles, 2020 Innate immunity is a first line of defence against danger. Exogenous pathogen- or microbe-associated molecular patterns (PAMPs or MAMPs) trigger innate immune responses through well-understood cellular pathways.
Yu Xiao +4 more
doaj +1 more source
Эпидемиология и вакцинопрофилактика, 2018 Vaccines for many years act as one of the most effective and successfully used medicines. Vaccines obtained by traditional methods contain in their composition live, weakened or killed microorganisms (bacteria, viruses, etc.).
O. A. Svitich +5 more
doaj +1 more source
Uridine composition of the poly-U/UC tract of HCV RNA defines non-self recognition by RIG-I. [PDF]
PLoS Pathogens, 2012 Viral infection of mammalian cells triggers the innate immune response through non-self recognition of pathogen associated molecular patterns (PAMPs) in viral nucleic acid.
Gretja Schnell +3 more
doaj +1 more source
Names, 1989 Lena Peterson's comments (Names 37: 83–92) misinterpret my main point (in Names 33 [1985]: 111–18) on the connection between names and other noun phrases. A printing error in the 1985 article also caused confusion for many readers.
Bengt Pamp
doaj +1 more source
Phosphorylation is required for the pathogen defense function of the Arabidopsis PEN3 ABC transporter. [PDF]
, 2017 The Arabidopsis PEN3 ABC transporter accumulates at sites of pathogen detection, where it is involved in defense against a number of pathogens. Perception of PAMPs by pattern recognition receptors initiates recruitment of PEN3 and also leads to PEN3 ...
Somerville, Shauna, Underwood, William
core +1 more source
The calcium-dependent protein kinase CPK28 negatively regulates the BIK1-mediated PAMP-induced calcium burst [PDF]
, 2015 Plants are protected from microbial infection by a robust immune system. Two of the earliest responses mediated by surface-localized immune receptors include an increase in cytosolic calcium (Ca(2+)) and a burst of apoplastic reactive oxygen species (ROS)
Matschi, Susanne +3 more
core +1 more source
Role of MPK4 in pathogen-associated molecular pattern-triggered alternative splicing in Arabidopsis.
PLoS Pathogens, 2020 Alternative splicing (AS) of pre-mRNAs in plants is an important mechanism of gene regulation in environmental stress tolerance but plant signals involved are essentially unknown.
Jeremie Bazin +6 more
doaj +1 more source
Creating materials with a desired refraction coefficient: numerical experiments [PDF]
, 2010 A recipe for creating materials with a desired refraction coefficient is implemented numerically. The following assumptions are used: \bee \zeta_m=h(x_m)/a^\kappa,\quad d=O(a^{(2-\kappa)/3}),\quad M=O(1/a^{2-\kappa}),\quad \kappa\in(0,1), \eee where ...
Indratno, Sapto W., Ramm, Alexander G.
core +7 more sources
Analysis of Functional Virus-generated PAMP RNAs Using IFNα/β ELISA Assay
Bio-Protocol, 2019 Virus-generated PAMP RNAs are key factors that activate host immune response. The PAMP RNAs are therefore usually closely related with viral disease pathogenesis. Quantitative real time PCR is a conventional method to assess RNA.
Margit Mutso +3 more
doaj +1 more source