Results 1 to 10 of about 23,370 (263)

Regulation of MRGPRX2-mediated mast cell function by competence-stimulating peptide 1 and pro-adrenomedullin peptide [PDF]

Frontiers in Immunology
IntroductionMas-related G protein-coupled receptor (GPCR)-X2 (MRGPRX2, mouse ortholog MrgprB2) is predominantly expressed in mast cells (MCs) and is activated by a wide range of cationic ligands such as bacterial quorum sensing molecules (QSMs) and pro ...
Aetas Amponnawarat, Aetas Amponnawarat, Sangita Sutradhar, Chalatip Chompunud Na Ayudhya, Maram Bawazir, Ronit Sagi-Eisenberg, Hydar Ali   +6 more
doaj   +2 more sources

Mediator subunit MED19 modulates elf18-induced PR1 expression via TGA transcription factors [PDF]

Plant Signaling & Behavior
The Mediator complex bridges transcription factors and RNA polymerase II to regulate gene expression during plant immune responses. We previously demonstrated that the Mediator subunit MED19a modulates PATHOGEN-RELATED 1 (PR1) expression through ...
Taeyoung Um, Gang-Seob Lee, Jun Sung Seo
doaj   +2 more sources

A DNA Vaccine Against Proadrenomedullin N-Terminal 20 Peptide (PAMP) Reduces Angiogenesis and Increases Lymphocyte and Macrophage Infiltration but Has No Effect on Tumor Burden in a Mouse Model of Lung Metastasis [PDF]

Vaccines
Background/Objectives: Nucleic acid-based anticancer vaccines are becoming a very active field in the fight against cancer. Here, our goal was to generate an oral DNA vaccine targeting the angiogenic peptide, proadrenomedullin N-terminal 20 peptide (PAMP)
Tom Kalathil Raju, Srdan Tadic, Pablo Garrido, Laura Ochoa-Callejero, Judit Narro-Íñiguez, Josune García-Sanmartín, Alfredo Martínez   +6 more
doaj   +2 more sources

Lipopolysaccharide detection by the innate immune system may be an uncommon defence strategy used in nature

Open Biology, 2022
Since the publication of the Janeway's Pattern Recognition hypothesis in 1989, study of pathogen-associated molecular patterns (PAMPs) and their immuno-stimulatory activities has accelerated.
Anna E. Gauthier, Randi D. Rotjan, Jonathan C. Kagan   +2 more
doaj   +1 more source

Sensor Sensibility—HIV-1 and the Innate Immune Response

Cells, 2020
Innate immunity represents the human immune system’s first line of defense against a pathogenic intruder and is initiated by the recognition of conserved molecular structures known as pathogen-associated molecular patterns (PAMPs) by specialized ...
Xin Yin, Simon Langer, Zeli Zhang, Kristina M. Herbert, Sunnie Yoh, Renate König, Sumit K. Chanda   +6 more
doaj   +1 more source

TNFa and IL2 Encoding Oncolytic Adenovirus Activates Pathogen and Danger-Associated Immunological Signaling

Cells, 2020
In order to break tumor resistance towards traditional treatments, we investigate the response of tumor and immune cells to a novel, cytokine-armed oncolytic adenovirus: Ad5/3-d24-E2F-hTNFa-IRES-hIL2 (also known as TILT-123 and OAd.TNFa-IL2).
Camilla Heiniö, Riikka Havunen, Joao Santos, Klaas de Lint, Victor Cervera-Carrascon, Anna Kanerva, Akseli Hemminki   +6 more
doaj   +1 more source

How does an RNA selfie work? EV-associated RNA in innate immunity as self or danger

Journal of Extracellular Vesicles, 2020
Innate immunity is a first line of defence against danger. Exogenous pathogen- or microbe-associated molecular patterns (PAMPs or MAMPs) trigger innate immune responses through well-understood cellular pathways.
Yu Xiao, Tom Driedonks, Kenneth W. Witwer, Qian Wang, Hang Yin   +4 more
doaj   +1 more source

Adrenomedullin: Not Just Another Gastrointestinal Peptide

Biomolecules, 2022
Adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) are two bioactive peptides derived from the same precursor with several biological functions including vasodilation, angiogenesis, or anti-inflammation, among others.
Sonia Martínez-Herrero, Alfredo Martínez   +1 more
doaj   +1 more source

Agonists of Receptors of the Innate Immunity and Defective Viral Particles as New Generation of Adjuvants

Эпидемиология и вакцинопрофилактика, 2018
Vaccines for many years act as one of the most effective and successfully used medicines. Vaccines obtained by traditional methods contain in their composition live, weakened or killed microorganisms (bacteria, viruses, etc.).
O. A. Svitich, V. F. Lavrov, P. I. Kukina, A. A. Iskandaryan, L. V. Gankovskaya, V. V. Zverev   +5 more
doaj   +1 more source

Comments on Comments

Names, 1989
Lena Peterson's comments (Names 37: 83–92) misinterpret my main point (in Names 33 [1985]: 111–18) on the connection between names and other noun phrases. A printing error in the 1985 article also caused confusion for many readers.
Bengt Pamp
doaj   +1 more source