Proadrenomedullin N-Terminal 20 Peptide (PAMP) Increases Proliferation and Induces Cytoskeleton Remodeling in Melanoma Cells Through the CXCR7/CXCR4/β-Arrestin Axis [PDF]
MoleculesGrowth factors are molecules that interact with specific membrane receptors and induce cellular proliferation. In malignancy, this growth factor–receptor interaction constitutes one of the “hallmarks of cancer” and may result in uncontrolled cell growth.
Tom Kalathil Raju +3 more
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Chimeric Pathogen-Associated Molecular Patterns (PAMPs) as Vaccine Adjuvants [PDF]
VaccinesThe development of pathogen-associated molecular patterns (PAMPs) that signal via pathogen recognition receptors (PRRs) on innate immune cells is a strategy that is widely adopted in adjuvant research.
Bethany M. Potter +4 more
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PAMP orchestrates proline metabolic rewiring to suppress LUAD via PYCR1 inhibition [PDF]
EMBO Molecular MedicineRecent advances in next-generation sequencing have revealed that long non-coding RNAs (lncRNAs) can encode functional micropeptides through small open reading frames (sORFs), altering the perception of the non-coding genome.
Yun Ma +10 more
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Regulation of MRGPRX2-mediated mast cell function by competence-stimulating peptide 1 and pro-adrenomedullin peptide [PDF]
Frontiers in ImmunologyIntroductionMas-related G protein-coupled receptor (GPCR)-X2 (MRGPRX2, mouse ortholog MrgprB2) is predominantly expressed in mast cells (MCs) and is activated by a wide range of cationic ligands such as bacterial quorum sensing molecules (QSMs) and pro ...
Aetas Amponnawarat +6 more
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Bacteria-mimicking cancer cells reprogram macrophages via multiple pattern recognition receptor pathways for cancer immunotherapy [PDF]
Signal Transduction and Targeted TherapyAlthough macrophages are a powerful cell-based platform for cancer immunotherapy, their antitumor functions, such as phagocytosis and inflammatory responses, are limited by the immunosuppressive tumor microenvironment.
Seoyoon Song +12 more
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RIG-I–dependent sensing of PEDV shapes epithelial antiviral immunity in the intestinal mucosa [PDF]
Journal of VirologyPorcine epidemic diarrhea virus (PEDV) is a highly contagious enteric coronavirus that causes lethal diarrhea in neonatal piglets, yet the viral pathogen-associated molecular patterns (PAMPs) that initiate mucosal antiviral immunity remain poorly defined.
Hui Zeng +10 more
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Sensor Sensibility—HIV-1 and the Innate Immune Response
Cells, 2020 Innate immunity represents the human immune system’s first line of defense against a pathogenic intruder and is initiated by the recognition of conserved molecular structures known as pathogen-associated molecular patterns (PAMPs) by specialized ...
Xin Yin +6 more
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Open Biology, 2022 Since the publication of the Janeway's Pattern Recognition hypothesis in 1989, study of pathogen-associated molecular patterns (PAMPs) and their immuno-stimulatory activities has accelerated.
Anna E. Gauthier +2 more
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Cells, 2020 In order to break tumor resistance towards traditional treatments, we investigate the response of tumor and immune cells to a novel, cytokine-armed oncolytic adenovirus: Ad5/3-d24-E2F-hTNFa-IRES-hIL2 (also known as TILT-123 and OAd.TNFa-IL2).
Camilla Heiniö +6 more
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How does an RNA selfie work? EV-associated RNA in innate immunity as self or danger
Journal of Extracellular Vesicles, 2020 Innate immunity is a first line of defence against danger. Exogenous pathogen- or microbe-associated molecular patterns (PAMPs or MAMPs) trigger innate immune responses through well-understood cellular pathways.
Yu Xiao +4 more
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