Results 11 to 20 of about 53,212 (301)
Regulation of MRGPRX2-mediated mast cell function by competence-stimulating peptide 1 and pro-adrenomedullin peptide [PDF]
Frontiers in ImmunologyIntroductionMas-related G protein-coupled receptor (GPCR)-X2 (MRGPRX2, mouse ortholog MrgprB2) is predominantly expressed in mast cells (MCs) and is activated by a wide range of cationic ligands such as bacterial quorum sensing molecules (QSMs) and pro ...
Aetas Amponnawarat +6 more
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Mediator subunit MED19 modulates elf18-induced PR1 expression via TGA transcription factors [PDF]
Plant Signaling & BehaviorThe Mediator complex bridges transcription factors and RNA polymerase II to regulate gene expression during plant immune responses. We previously demonstrated that the Mediator subunit MED19a modulates PATHOGEN-RELATED 1 (PR1) expression through ...
Taeyoung Um, Gang-Seob Lee, Jun Sung Seo
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Proadrenomedullin NH2-terminal 20 peptide (PAMP) and adrenomedullin bind to teratocarcinoma cells☆ [PDF]
Peptides, 2000 Proadrenomedullin NH(2-)terminal 20 peptide (PAMP) and adrenomedullin (ADM) bind to teratocarcinoma cells. The effects of PAMP and ADM on teratocarcinoma cells were investigated.
D Coy +2 more
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A DNA Vaccine Against Proadrenomedullin N-Terminal 20 Peptide (PAMP) Reduces Angiogenesis and Increases Lymphocyte and Macrophage Infiltration but Has No Effect on Tumor Burden in a Mouse Model of Lung Metastasis [PDF]
VaccinesBackground/Objectives: Nucleic acid-based anticancer vaccines are becoming a very active field in the fight against cancer. Here, our goal was to generate an oral DNA vaccine targeting the angiogenic peptide, proadrenomedullin N-terminal 20 peptide (PAMP)
Tom Kalathil Raju +6 more
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Exploiting vita-PAMPs in vaccines [PDF]
Current Opinion in Pharmacology, 2018 Live attenuated vaccines elicit stronger protective immunity than dead vaccines. Distinct PAMPs designated as vita-PAMPs signify microbial viability to innate immune cells. Two vita-PAMPs have been characterized: cyclic-di-adenosine-monophosphate (c-di-AMP) and prokaryotic messenger RNA (mRNA).
J Magarian, Blander, Gaetan, Barbet
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Open Biology, 2022 Since the publication of the Janeway's Pattern Recognition hypothesis in 1989, study of pathogen-associated molecular patterns (PAMPs) and their immuno-stimulatory activities has accelerated.
Anna E. Gauthier +2 more
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Cells, 2020 In order to break tumor resistance towards traditional treatments, we investigate the response of tumor and immune cells to a novel, cytokine-armed oncolytic adenovirus: Ad5/3-d24-E2F-hTNFa-IRES-hIL2 (also known as TILT-123 and OAd.TNFa-IL2).
Camilla Heiniö +6 more
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Sensor Sensibility—HIV-1 and the Innate Immune Response
Cells, 2020 Innate immunity represents the human immune system’s first line of defense against a pathogenic intruder and is initiated by the recognition of conserved molecular structures known as pathogen-associated molecular patterns (PAMPs) by specialized ...
Xin Yin +6 more
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Sweeten PAMPs: role of sugar complexed PAMPs in innate immunity and vaccine biology [PDF]
Frontiers in Immunology, 2013 Innate sensors play a critical role in the early innate immune responses to invading pathogens through sensing of diverse biochemical signatures also known as pathogen associated molecular patterns (PAMPs). These biochemical signatures primarily consist of a major family of biomolecules such as proteins, lipids, nitrogen bases, and sugar and its ...
Ranjeet Singh Mahla +4 more
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Adrenomedullin: Not Just Another Gastrointestinal Peptide
Biomolecules, 2022 Adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) are two bioactive peptides derived from the same precursor with several biological functions including vasodilation, angiogenesis, or anti-inflammation, among others.
Sonia Martínez-Herrero +1 more
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