Results 11 to 20 of about 23,370 (263)
Exploiting vita-PAMPs in vaccines [PDF]
Current Opinion in Pharmacology, 2018 Live attenuated vaccines elicit stronger protective immunity than dead vaccines. Distinct PAMPs designated as vita-PAMPs signify microbial viability to innate immune cells. Two vita-PAMPs have been characterized: cyclic-di-adenosine-monophosphate (c-di-AMP) and prokaryotic messenger RNA (mRNA).
J Magarian, Blander, Gaetan, Barbet
openaire +4 more sources
Sweeten PAMPs: role of sugar complexed PAMPs in innate immunity and vaccine biology [PDF]
Frontiers in Immunology, 2013 Innate sensors play a critical role in the early innate immune responses to invading pathogens through sensing of diverse biochemical signatures also known as pathogen associated molecular patterns (PAMPs). These biochemical signatures primarily consist of a major family of biomolecules such as proteins, lipids, nitrogen bases, and sugar and its ...
Ranjeet Singh Mahla +4 more
openaire +3 more sources
A new paradigm: 46 structural cell types function as environment-supporting innate immune cells, with endothelial and vascular smooth muscle cells as key prototypes. [PDF]
Inew MedABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Liu J +22 more
europepmc +2 more sources
Uridine composition of the poly-U/UC tract of HCV RNA defines non-self recognition by RIG-I. [PDF]
PLoS Pathogens, 2012 Viral infection of mammalian cells triggers the innate immune response through non-self recognition of pathogen associated molecular patterns (PAMPs) in viral nucleic acid.
Gretja Schnell +3 more
doaj +1 more source
Role of MPK4 in pathogen-associated molecular pattern-triggered alternative splicing in Arabidopsis.
PLoS Pathogens, 2020 Alternative splicing (AS) of pre-mRNAs in plants is an important mechanism of gene regulation in environmental stress tolerance but plant signals involved are essentially unknown.
Jeremie Bazin +6 more
doaj +1 more source
Analysis of Functional Virus-generated PAMP RNAs Using IFNα/β ELISA Assay
Bio-Protocol, 2019 Virus-generated PAMP RNAs are key factors that activate host immune response. The PAMP RNAs are therefore usually closely related with viral disease pathogenesis. Quantitative real time PCR is a conventional method to assess RNA.
Margit Mutso +3 more
doaj +1 more source
Sensing the hybrid—a novel PAMP for TLR9 [PDF]
The EMBO Journal, 2014 The host immune response is initiated by pattern recognition receptors (PRR) when triggered by specific ligands known as pathogen-associated molecular patterns (PAMP). Toll-like receptor 9 is highly expressed in plasmacytoid dendritic cells and is well described as a PRR for CpG DNA which induce the production of cytokines and type I interferons.
Søren B, Jensen, Søren R, Paludan
openaire +2 more sources
Anatolian Journal of Cardiology, 2023 Background: We evaluated the predictive value of electrocardiographic (ECG) findings for pulmonary hemodynamics assessed by right heart catheterization (RHC).
Hacer Ceren Tokgöz +16 more
doaj +1 more source
γHV68 vGAT: A Viral Pseudoenzyme Pimping for PAMPs [PDF]
Molecular Cell, 2015 In this issue, He et al. (2015) show how herpes virus usurps a cellular metabolic enzyme to induce RIG-I deamidation and RNA-independent activation, likely to better prevent further innate immune responses.
Kolakofsky Daniel, Garcin Dominique
openaire +5 more sources
PAMPs and DAMPs as triggers for DIC [PDF]
Journal of Intensive Care, 2014 Thrombosis is generally considered harmful because it compromises the blood supply to organs. However, recent studies have suggested that thrombosis under certain circumstances plays a major physiological role in early immune defense against invading pathogens. This defensive role of thrombosis is now referred to as immunothrombosis.
openaire +2 more sources