Results 81 to 90 of about 3,191,959 (309)

Systematic pan-cancer analysis of tumour purity [PDF]

Nature Communications, 2015
Abstract The tumour microenvironment is the non-cancerous cells present in and around a tumour, including mainly immune cells, but also fibroblasts and cells that comprise supporting blood vessels. These non-cancerous components of the tumour may play an important role in cancer biology.
Aran, Dvir, Sirota, Marina, Butte, Atul J.   +2 more
openaire   +2 more sources

Prospero homeobox 1 promotes epithelial-mesenchymal transition in colon cancer cells by inhibiting E-cadherin via miR-9

, 2012
[[abstract]]PURPOSE: Prospero homeobox 1 (PROX1) has been shown to function as a tumor suppressor in various types of cancer. However, it promotes colon cancer progression.
Lu, MH;Huang, CC;Pan, MR;Chen, HH;Hung, WC
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Nucleotide metabolism: a pan-cancer metabolic dependency

Nature Reviews Cancer, 2023
Metabolic alterations are a key hallmark of cancer cells, and the augmented synthesis and use of nucleotide triphosphates is a critical and universal metabolic dependency of cancer cells across different cancer types and genetic backgrounds. Many of the aggressive behaviours of cancer cells, including uncontrolled proliferation, chemotherapy resistance,
Nicholas J. Mullen, Pankaj K. Singh
openaire   +2 more sources

Systematic pan-cancer analysis identifies RALA as a tumor targeting immune therapeutic and prognostic marker

Frontiers in Immunology, 2022
IntroductionRALA is a member of the small GTPase Ras superfamily and has been shown to play a role in promoting cell proliferation and migration in most tumors, and increase the resistance of anticancer drugs such as imatinib and cisplatin. Although many
Haoer Jin, Haoer Jin, Sha Qin, Sha Qin, Jiang He, Juxiong Xiao, Qingling Li, Qingling Li, Yitao Mao, Yitao Mao, Luqing Zhao, Luqing Zhao, Luqing Zhao   +12 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Pan‑cancer analysis of the deoxyribonuclease gene family

Molecular and Clinical Oncology, 2023
Deoxyribonuclease (DNase) is an enzyme that catalyzes the cleavage of phosphodiester bonds in the main chain of DNA to degrade DNA. DNase serves a vital role in several immune-related diseases. The present study linked the expression of DNase with overall survival (OS), performed pan-cancer co-expression analysis, and assessed the association between ...
Bai, Qingquan, He, Xiao, Hu, Tianhui
openaire   +2 more sources

Towards a potential pan-cancer prognostic signature for gene expression based on probesets and ensemble machine learning

BioData Mining, 2022
Cancer is one of the leading causes of death worldwide and can be caused by environmental aspects (for example, exposure to asbestos), by human behavior (such as smoking), or by genetic factors.
Davide Chicco, Abbas Alameer, Sara Rahmati, Giuseppe Jurman   +3 more
doaj   +1 more source

Genetic Alterations in the PI3K/AKT Pathway and Baseline AKT Activity Define AKT Inhibitor Sensitivity in Breast Cancer Patient-derived Xenografts.

, 2020
PURPOSE: AZD5363/capivasertib is a pan-AKT catalytic inhibitor with promising activity in combination with paclitaxel in triple-negative metastatic breast cancer harboring PI3K/AKT-pathway alterations and in estrogen receptor-positive breast cancer in ...
Mills, GB, Saura, C, Serra, V, Sánchez-Guixé, M, Palafox, M, Ibrahim, YH, Arribas, J, Monserrat, L, Reddy, A, Guzmán, M, Nuciforo, P, Barnicle, A, Oliveira, M, de Bruin, EC, Prat, A, Scaltriti, M, Bruna, A, Hirst, CS, Grueso, J, Parés, M, Brasó-Maristany, F, Davies, BR, Caldas, C, Villacampa, G, Schiavon, G, Turner, NC, Gris-Oliver, A, Rodríguez, O, Razavi, P, Dienstmann, R, Òdena, A   +30 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source