Results 251 to 260 of about 1,691,339 (303)

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

open access: yesAdvanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song   +7 more
wiley   +1 more source

Gene-level analysis of core carbohydrate metabolism across the Enterobacteriaceae pan-genome. [PDF]

open access: yesCommun Biol
Näpflin N   +4 more
europepmc   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

open access: yesAdvanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang   +9 more
wiley   +1 more source

Pan-genome analysis reveals the evolution and diversity of Malus. [PDF]

open access: yesNat Genet
Li W   +26 more
europepmc   +1 more source

Pan-Genome in the Research of Bamboology

open access: yesHans Journal of Agricultural Sciences, 2016
openaire   +1 more source

Integrating pan-genome analysis, GWAS, and interpretable machine learning to prioritize trait-associated structural variations in Setaria italica. [PDF]

open access: yesPlant Commun
Wang W   +13 more
europepmc   +1 more source

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