Results 231 to 240 of about 1,691,339 (303)

Pan-genome-wide characterization of the ascorbate peroxidase gene family reveals evolutionary dynamics and salt-responsive mechanisms in Fraxinus. [PDF]

BMC Plant Biol
Hou C, Yan L, Liu W, Liu JN, Liu Z.
europepmc   +1 more source

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source

Genomic adaptability and virulence of Bacillus anthracis: a machine learning-based pan-genome and comparative analysis. [PDF]

BMC Genomics
Sekar YS, Chellapandi P, Suresh KP, Saranya SV, Papanna M, Gulati BR, Amachawadi RG, Khatoon M, Hemadri D, Archana CA, Rani S, Patil A, Palavesam A, Sagar N, Anand J, Patil SS.   +15 more
europepmc   +1 more source

Learning Work Function via Implicit Reasoning on Electrostatic Potential Landscapes

Advanced Science, EarlyView.
StructPot‐CLR establishes a cross‐modal contrastive learning framework that aligns the crystal structures of 2D materials with plane‐averaged electrostatic potential landscapes for physically informed work‐function prediction. The model achieves an MAE of 0.265 eV and an R2 of 0.902 on the held‐out test set while accurately preserving key morphological
Haoyu Wan, Yue Wu, Tianhao Su, Deng Pan
wiley   +1 more source

Pan-Genome Analysis of the Fructokinase Gene Family Reveals a Light-Regulated SiPhyC-SiFRK4 Module Controlling Carbon Partitioning in Foxtail Millet. [PDF]

Plants (Basel)
He L, Zhao J, Wang G, Yuan L, Wang X, Yang Z.   +5 more
europepmc   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Insights into novel diagnostic assay development, antimicrobial resistance, and pathogenicity in <i>Proteus mirabilis</i> through pan-genome analysis. [PDF]

Appl Environ Microbiol
Yin Z, Chen X, Xiao J, Tian X, Li Z, Zhang M, Jing B, Li D, Deng X, Peng L.   +9 more
europepmc   +1 more source

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

Advanced Science, EarlyView.
Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, an sonothermal‐responsive platform has been developed through constructing metal‐semiconductor interface on implants. Biofilm infection and deep vein thrombosis can be successfully treated by controllable ultrasound treatments.
Zhengdong Zhang, Pan Liu, Jie Lei, Shuchang Peng, Qiu Chen, Wei Guan, Yizhou Zhu, Gang Liu, Xiaobo Feng, Cao Yang, Lei Tan   +10 more
wiley   +1 more source

The phased pan-genome of tetraploid European potato. [PDF]

Nature
Sun H, Tusso S, Dent CI, Goel M, Wijfjes RY, Baus LC, Dong X, Campoy JA, Kurdadze A, Walkemeier B, Sänger C, Huettel B, Hutten RCB, van Eck HJ, Dehmer KJ, Schneeberger K.   +15 more
europepmc   +1 more source