Results 241 to 250 of about 1,691,339 (303)

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Enviromics and Abiotic Enviromics: Enhancing Stress Biology and Plant Resilience Breeding

Advanced Science, EarlyView.
Environmental stressors are captured through high‐throughput envirotyping and integrated into an enviromic framework with genomic, transcriptomic, phenomic, and environmental data. AI/ML models enable prediction and guide marker‐assisted selection, genomic selection, genome editing, and gene pyramiding toward improved abiotic stress tolerance, yield ...
Guangchao Sun, Jose Luis Araus, James C. Schnable, Jie Xu, Henry T. Nguyen, Yunbi Xu, Yanli Lu   +6 more
wiley   +1 more source

Mitochondrial Graph-Based Pan-Genome Analysis of <i>Hypsizygus marmoreus</i>: Structural Variation, Adaptive Evolution, and Its Implications for Germplasm Resource Improvement. [PDF]

Int J Mol Sci
Ma R, Li W, Miao Y, Yang R, Shao Y, Shang J, Li Y, Gao Y, Bao D, Wu Y.   +9 more
europepmc   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Gramene 2025: expanded comparative genomics and pathway resources, integrated search, and pan-genome portals for crop research. [PDF]

Nucleic Acids Res
Olson A, Kumari S, Wei X, Chougule K, Lu Z, Tello-Ruiz MK, Kumar V, Van Buren P, Olson A, Kim C, Braynen J, Zhang L, Dyer S, Alvarez-Jarreta J, Saraf S, Contreras-Moreira B, Naamati G, Ernst C, Papatheodorou I, George N, Jaiswal P, Naithani S, Gupta P, Elser J, D'Eustachio P, Assmann SM, Ferrero-Serrano Á, Pasha A, Provart N, Gladman N, Ware D.   +30 more
europepmc   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

Pan-genome analysis of wax apple (<i>Syzygium samarangense</i>) and its association with fruit size and cold tolerance. [PDF]

Front Plant Sci
Long X, Li L, Fang R, Zhang J, Zhou P, An Z, Tang W, Yao J, Wei X.   +8 more
europepmc   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

De novo annotation reveals transcriptomic complexity across the hexaploid wheat pan-genome. [PDF]

Nat Commun
White B, Lux T, Rusholme-Pilcher R, Juhász A, Kaithakottil G, Duncan S, Simmonds J, Rees H, Wright J, Colmer J, Ward S, Joynson R, Coombes B, Irish N, Henderson S, Barker T, Chapman H, Catchpole L, Gharbi K, Bose U, Okada M, Handa H, Nasuda S, Shimizu KK, Gundlach H, Lang D, Naamati G, Legg EJ, Bharti AK, Colgrave ML, Haerty W, Uauy C, Swarbreck D, Borrill P, Poland JA, Krattinger SG, Stein N, Mayer KFX, Pozniak C, 10+ Wheat Genome Project, Spannagl M, Hall A.   +41 more
europepmc   +1 more source

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source