Results 221 to 230 of about 171,414 (293)

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

The phased pan-genome of tetraploid European potato. [PDF]

Nature
Sun H, Tusso S, Dent CI, Goel M, Wijfjes RY, Baus LC, Dong X, Campoy JA, Kurdadze A, Walkemeier B, Sänger C, Huettel B, Hutten RCB, van Eck HJ, Dehmer KJ, Schneeberger K.   +15 more
europepmc   +1 more source

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Gramene 2025: expanded comparative genomics and pathway resources, integrated search, and pan-genome portals for crop research. [PDF]

Nucleic Acids Res
Olson A, Kumari S, Wei X, Chougule K, Lu Z, Tello-Ruiz MK, Kumar V, Van Buren P, Olson A, Kim C, Braynen J, Zhang L, Dyer S, Alvarez-Jarreta J, Saraf S, Contreras-Moreira B, Naamati G, Ernst C, Papatheodorou I, George N, Jaiswal P, Naithani S, Gupta P, Elser J, D'Eustachio P, Assmann SM, Ferrero-Serrano Á, Pasha A, Provart N, Gladman N, Ware D.   +30 more
europepmc   +1 more source

Pan-genome analysis of wax apple (<i>Syzygium samarangense</i>) and its association with fruit size and cold tolerance. [PDF]

Front Plant Sci
Long X, Li L, Fang R, Zhang J, Zhou P, An Z, Tang W, Yao J, Wei X.   +8 more
europepmc   +1 more source

De novo annotation reveals transcriptomic complexity across the hexaploid wheat pan-genome. [PDF]

Nat Commun
White B, Lux T, Rusholme-Pilcher R, Juhász A, Kaithakottil G, Duncan S, Simmonds J, Rees H, Wright J, Colmer J, Ward S, Joynson R, Coombes B, Irish N, Henderson S, Barker T, Chapman H, Catchpole L, Gharbi K, Bose U, Okada M, Handa H, Nasuda S, Shimizu KK, Gundlach H, Lang D, Naamati G, Legg EJ, Bharti AK, Colgrave ML, Haerty W, Uauy C, Swarbreck D, Borrill P, Poland JA, Krattinger SG, Stein N, Mayer KFX, Pozniak C, 10+ Wheat Genome Project, Spannagl M, Hall A.   +41 more
europepmc   +1 more source

Born this way: Does variation in perinatal limb bone morphology predict adult locomotor repertoire in primates?

The Anatomical Record, EarlyView.
Abstract Primates show a high degree of locomotor diversity that engenders similar variance in limb bone cross‐sectional geometry and bending strength: leaping primates have stronger hindlimb bones whereas suspensory species have stronger forelimb bones.
Angela M. Mossor, Jeremy Busken, Lorna Benden, Ethan Mardovin, Andrew Bostick, Grégoire Boulinguez‐Ambroise, Timothy D. Smith, Jesse W. Young   +7 more
wiley   +1 more source

Comparative Genomic Analysis of <i>Brevibacillus brevis</i>: Insights into Pan-Genome Diversity and Biocontrol Potential. [PDF]

Microorganisms
Yang W, Bao Q, Wang Y, Xiao L, Zeng Z, Zhou L, Yang H.   +6 more
europepmc   +1 more source