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Comparative genomics: the bacterial pan-genome
Current Opinion in Microbiology, 2008Bacterial genome sequencing has become so easy and accessible that the genomes of multiple strains of more and more individual species have been and will be generated. These data sets provide for in depth analysis of intra-species diversity from various aspects.
Hervé, Tettelin +3 more
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Ten years of pan-genome analyses
Current Opinion in Microbiology, 2015Next generation sequencing technologies have engendered a genome sequence data deluge in public databases. Genome analyses have transitioned from single or few genomes to hundreds to thousands of genomes. Pan-genome analyses provide a framework for estimating the genomic diversity of the dataset at hand and predicting the number of additional whole ...
George, Vernikos +3 more
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Journal of Clinical Oncology, 2019
3099 Background: FGFR2 genomic alterations (GA) have been described in a variety of solid tumors and emerged as biomarkers for investigational agents undergoing clinical trials. Methods: 201,766 primarily relapsed/refractory malignancies were evaluated with a hybrid-capture based sequencing assay Tumor mutational burden (TMB) was determined on 0.8-1 ...
Russell Madison +19 more
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3099 Background: FGFR2 genomic alterations (GA) have been described in a variety of solid tumors and emerged as biomarkers for investigational agents undergoing clinical trials. Methods: 201,766 primarily relapsed/refractory malignancies were evaluated with a hybrid-capture based sequencing assay Tumor mutational burden (TMB) was determined on 0.8-1 ...
Russell Madison +19 more
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Pan-Genome of Brucella Species
Indian Journal of Microbiology, 2014Whole-genome sequencing of bacterial pathogens has high impact on diagnosis and development of prophylaxis to human and veterinary disease. To study the genetic variations and relatedness among Brucella spp., we have examined the pan-genomic content of 18 Brucella complete genomes from NCBI using GView and Panseq server.
Jagadesan Sankarasubramanian +4 more
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The Bacterial Pan-Genome and Reverse Vaccinology
2009The whole genome sequence of most human bacterial pathogens is available and the advent of next-generation sequencing technologies will result in a large number of sequenced isolates per pathogenic species. The study of multiple genome sequences of a given bacterium provides insights into its evolution, pathogenic potential and diversity.
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Pan-genome analysis of 33 genetically diverse rice accessions reveals hidden genomic variations
Cell, 2021Peng Qin, Weilan Chen, Shujun Ou
exaly
2019
The notion of pan-genome or genome graph, understood as the representation of all variant genomes of one or more closely related species, is gaining attractiveness to replace the classical, sequence-based, linear reference genome. Indeed, one of main reasons why most analyses are based on the linear reference genome is simplicity: simplicity of ...
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The notion of pan-genome or genome graph, understood as the representation of all variant genomes of one or more closely related species, is gaining attractiveness to replace the classical, sequence-based, linear reference genome. Indeed, one of main reasons why most analyses are based on the linear reference genome is simplicity: simplicity of ...
openaire +1 more source
Toward a high-quality pan-genome landscape ofBacillus subtilisby removal of confounding strains
Briefings in Bioinformatics, 2021Dan Wang, Feng Gao
exaly