Results 111 to 120 of about 811,378 (409)

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Pancreas Volume Declines During the First Year After Diagnosis of Type 1 Diabetes and Exhibits Altered Diffusion at Disease Onset

Diabetes Care, 2018
OBJECTIVE This study investigated the temporal dynamics of pancreas volume and microstructure in children and adolescents with recent-onset type 1 diabetes (T1D) and individuals without diabetes, including a subset expressing autoantibodies associated ...
John Virostko, Jonathan M. Williams, M. Hilmes, C. Bowman, Jordan J. Wright, L. Du, Hakmook Kang, W. Russell, A. Powers, D. Moore   +9 more
semanticscholar   +1 more source

The impact of pancreatic duct stent placement on the clinically relevant postoperative pancreatic fistula rate for high-risk anastomoses: a systematic review and meta-analysis

BMC Gastroenterology
Background To evaluate the impact of pancreatic duct stent outcomes on the prognosis of postoperative pancreatic fistula in patients with high-risk anastomoses.
Yuran Dai, Xiaozhi Lu, Lei Jiang, Zipeng Lu, Kuirong Jiang, Yi Miao, Jishu Wei   +6 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

OPTN/SRTR 2016 Annual Data Report: Pancreas

American Journal of Transplantation, 2018
The number of pancreas transplants performed in the United States increased by 7.0% in 2016 over the previous year, the first such increase in more than a decade, largely attributable to an increase in simultaneous kidney pancreas transplants. Transplant
Raja Kandaswamy, Peter G. Stock, S. Gustafson, M. Skeans, M. A. Curry, M. Prentice, A. Fox, A. Israni, J. Snyder, Bertram Kasiske   +9 more
semanticscholar   +1 more source

Relative Stability of Network States in Boolean Network Models of Gene Regulation in Development

, 2015
Progress in cell type reprogramming has revived the interest in Waddington's concept of the epigenetic landscape. Recently researchers developed the quasi-potential theory to represent the Waddington's landscape.
d'Hèrouël, Aymeric Fouquier, Huang, Sui, Price, Nathan D., Samal, Areejit, Zhou, Joseph Xu   +4 more
core   +1 more source

Technical Note: Enhancing Soft Tissue Contrast And Radiation‐Induced Image Changes With Dual‐Energy CT For Radiation Therapy [PDF]

, 2018
Purpose The purpose of this work is to investigate the use of low‐energy monoenergetic decompositions obtained from dual‐energy CT (DECT) to enhance image contrast and the detection of radiation‐induced changes of CT textures in pancreatic cancer ...
Alvarez, Chen, Feng, Frellessen, Hardie, Herfarth, Johnson, Kalra, Kaup, Mayer, Morrow, Noid, Schneider, Sudarski, Sudarski, Watanabe, Wichmann, Yu   +17 more
core   +2 more sources

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

The Artificial Pancreas [PDF]

Diabetes, 2012
The discovery of insulin was lifesaving. However, it converted type 1 diabetes, which had been an acute and lethal disease, into a chronic disease, with its attendant complications. It had long been considered—and was clearly demonstrated in the Diabetes Control and Complications Trial (1)—that microvascular complications such as retinopathy ...
openaire   +3 more sources

Fully Automated Pancreas Segmentation with Two-stage 3D Convolutional Neural Networks [PDF]

arXiv, 2019
Due to the fact that pancreas is an abdominal organ with very large variations in shape and size, automatic and accurate pancreas segmentation can be challenging for medical image analysis. In this work, we proposed a fully automated two stage framework for pancreas segmentation based on convolutional neural networks (CNN).
arxiv