Results 141 to 150 of about 501,228 (292)

Interferon‐Driven Biomarkers and Synergistic Therapy for PRMT5 Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer exhibits variable sensitivity to PRMT5 inhibition. Basal interferon signaling is identified as a key biomarker of response. PARP inhibition with olaparib induces IFN signaling, sensitizing resistant TNBC cells to PRMT5 inhibitors.
Ziwen Zhang, Sheyu Zhang, Lu Guo, Yichun Pan, Juan Huang, Yishuai Ji, Jiaqi Tao, Yong Wei, Xiaojia Wang, Qin Wu   +9 more
wiley   +1 more source

Comparison of "Continuous" and "End-ischemic" Approaches of Oxygenated Hypothermic Machine Perfusion for Pancreas Preservation. [PDF]

Transplant Direct
Elzawahry MAME, Fallon J, Hastoy B, Lo Faro ML, Nawaz S, Branchereau J, Clark A, Friend P, Ploeg R, Hunter J.   +9 more
europepmc   +1 more source

The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor [PDF]

, 2015
Kazuto Taniguchi, Mark A. Russell, Sarah J. Richardson, Noel G. Morgan   +3 more
openalex   +1 more source

Annular Pancreas

Annals of Surgery, 1957
openaire   +3 more sources

Lactylated SPTAN1 Accelerates Hepatocellular Carcinoma Progression by Promoting NOTCH1/HES1 Activation and Immunosuppression

Advanced Science, EarlyView.
This study identifies SPTAN1‐kla as a novel oncogenic driver in HBV‐driven HCC, linking metabolic, epigenetic, and immune mechanisms. SPTAN1‐kla promotes HCC progression via NOTCH1/HES1 activation and immunosuppression. Findings highlight that targeting SPTAN1‐kla provides a framework for HCC treatment to improve clinical outcomes in HBV infected ...
Zengbin Wang, Dongjie Ye, Linqing Wu, Jiayu Liu, Banglun Pan, Zhu Zhang, Xiaoxia Zhang, Yuxin Yao, Nanhong Tang   +8 more
wiley   +1 more source

Morphological and functional alterations in type 2 diabetes pancreata assessed with MRI-based metrics and [¹⁸F]FP-(+)-DTBZ PET. [PDF]

Front Endocrinol (Lausanne)
Nejati SF, Sadabad FE, Ren R, Huang Y, Bini J.   +4 more
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Retrograde Double-Balloon Enteroscopy Endoscopic Retrograde Pancreatography With Interventional Radiology Rendezvous of a Transplanted Pancreas. [PDF]

ACG Case Rep J
Bayudan A, Wang M, Kolli P, Larsen M.
europepmc   +1 more source

YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination

Advanced Science, EarlyView.
The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu, Wenzhi Du, Yongwen Luo, Jiageng Shi, Tianyun Liu, Meng Ji, Kangping Xiong, Siming Chen, Fenfang Zhou, Mingxing Li, Jingtian Yu, Gang Wang, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Kaiyu Qian   +16 more
wiley   +1 more source

Imbalance of the Immune Response According to Alcohol Consumption Patterns

Mediators of Inflammation
Moises Martinez-Castillo, Abigail Hernandez-Barragan, Daniel Santana-Vargas, Zaira Medina-Avila, Marisela Hernandez-Santillan, Adrian Flores-Sanchez, Itzel Altamirano-Mendoza, Fatima Higuera-De La Tijera, Aldo Torre-Delgadillo, Jaqueline Cordova-Gallardo, José Luis Pérez-Hernández, Gabriela Gutierrez-Reyes   +11 more
doaj   +1 more source