Results 161 to 170 of about 714,927 (305)

Translating the blueprint of cell fate: eIF5A-mediated translation regulates cellular identity in the pancreas. [PDF]

Mol Metab
Overton DL, Villaca CB, Dale DJ, Rutan CD, Robertson MA, Connors CT, Anderson-Baucum EK, Mastracci TL.   +7 more
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Enteric-drained pancreas transplants monitored by fine-needle aspiration biopsy [PDF]

, 1997
A. Sugitani, C. Vivas, Corry, Egidi, Egidi, Egidi, H.A. Gritsch, J.J. Fung, Klassen, M. Jordan, M.F. Egidi, R. Shapiro, R.J. Corry, Sollinger, Sutherland, T.E. Starzl, V. Scantlebury   +16 more
core   +2 more sources

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Fatty Liver and Pancreatic Steatosis in Patients with Chronic Hepatitis B and C and Wilson's Disease. [PDF]

Sisli Etfal Hastan Tip Bul
Aksoy M, Gelebek F, Lule KO, Lule NO, Yildirim AE, Barutcu S.   +5 more
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Imbalance of the Immune Response According to Alcohol Consumption Patterns

Mediators of Inflammation
Moises Martinez-Castillo, Abigail Hernandez-Barragan, Daniel Santana-Vargas, Zaira Medina-Avila, Marisela Hernandez-Santillan, Adrian Flores-Sanchez, Itzel Altamirano-Mendoza, Fatima Higuera-De La Tijera, Aldo Torre-Delgadillo, Jaqueline Cordova-Gallardo, José Luis Pérez-Hernández, Gabriela Gutierrez-Reyes   +11 more
doaj   +1 more source

Chronic Alcohol Consumption Induces Irreversible and Heterogeneous Pancreatic Steatosis in Men: An MRI-Based Cross-Sectional Study. [PDF]

J Clin Med
Zhao Y, Yang W, Tang C, Li J.
europepmc   +1 more source

Early Radiation Therapy Response Assessment Using Multi‐Scale Photoacoustic Imaging

Advanced Science, EarlyView.
Tomographic and mesoscopic photoacoustics capture intratumoural features of radioresistance and response. ABSTRACT There is a critical unmet clinical need to identify biomarkers that predict and detect radiation therapy (RT) response in cancer. Using the unique capabilities of multi‐scale photoacoustic imaging (PAI) to depict tumor oxygenation and ...
Thierry L. Lefebvre, Mariam‐Eleni Oraiopoulou, Ellie V. Bunce, Thomas R. Else, Lorna C. Wright, Monika A. Golinska, Lina Hacker, Cara Brodie, Steven Kupczak, Yi Cheng, Lisa Young, Paul W. Sweeney, Sarah E. Bohndiek   +12 more
wiley   +1 more source

Rapid Development of Diffuse-Type Remnant Pancreatic Cancer Following Obstructive Pancreatitis after Pancreaticoduodenectomy for Distal Bile Duct Carcinoma: A Case Report. [PDF]

Surg Case Rep
Tomioka A, Kawaguchi N, Kurisu Y, Ueda Y, Kushiyama S, Hamamoto H, Tanaka R, Imai Y, Komeda K, Asakuma M, Tomiyama H, Lee SW.   +11 more
europepmc   +1 more source