Results 81 to 90 of about 974,159 (389)

Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes.

JCI Insight, 2018
BACKGROUND Neutrophils and their inflammatory mediators are key pathogenic components in multiple autoimmune diseases, while their role in human type 1 diabetes (T1D), a disease that progresses sequentially through identifiable stages prior to the ...
Federica Vecchio, Nicola Lo Buono, A. Stabilini, L. Nigi, M. Dufort, S. Geyer, P. Rancoita, F. Cugnata, A. Mandelli, A. Valle, P. Leete, F. Mancarella, P. Linsley, L. Krogvold, K. Herold, H. Larsson, S. Richardson, N. Morgan, K. Dahl-Jørgensen, G. Sebastiani, F. Dotta, E. Bosi, M. Battaglia   +22 more
semanticscholar   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

EUS-FNA versus EUS-FNB in Pancreatic Solid Lesions ≤ 15 mm

Diagnostics
A small tumor size may impact the diagnostic performance of endoscopic ultrasound-guided tissue acquisition (EUS-TA) for diagnosing solid pancreatic lesions (SPLs).
Maria Cristina Conti Bellocchi, Micol Bernuzzi, Alessandro Brillo, Laura Bernardoni, Antonio Amodio, Nicolò De Pretis, Luca Frulloni, Armando Gabbrielli, Stefano Francesco Crinò   +8 more
doaj   +1 more source

Predictors of distant metastasis on exploration in patients with potentially resectable pancreatic cancer

BMC Gastroenterology, 2018
Background Patients with potentially resectable pancreatic ductal adenocarcinoma (PDAC) are frequently found to be unresectable on exploration due to small distant metastasis.
Xinchun Liu, Yue Fu, Qiuyang Chen, Junli Wu, Wentao Gao, Kuirong Jiang, Yi Miao, Jishu Wei   +7 more
doaj   +1 more source

Early Nasojejunal Nutrition Versus Early Oral Feeding in Patients After Pancreaticoduodenectomy: A Randomized Controlled Trial

Frontiers in Oncology, 2021
ObjectiveThe aim of this study was to test the hypothesis that early oral feeding (EOF) is superior to early nasojejunal nutrition (ENN) after pylorus-preserving pancreaticoduodenectomy (PPPD) in terms of delayed gastric emptying (DGE).BackgroundDGE is a
Xinchun Liu, Xinchun Liu, Qiuyang Chen, Yue Fu, Zipeng Lu, Jianmin Chen, Feng Guo, Qiang Li, Junli Wu, Wentao Gao, Kuirong Jiang, Cuncai Dai, Yi Miao, Jishu Wei   +13 more
doaj   +1 more source

Towards dense volumetric pancreas segmentation in CT using 3D fully convolutional networks

, 2018
Pancreas segmentation in computed tomography imaging has been historically difficult for automated methods because of the large shape and size variations between patients. In this work, we describe a custom-build 3D fully convolutional network (FCN) that
Fujiwara, Michitaka, Hayashi, Yuichiro, Kitasaka, Takayuki, Misawa, Kazunari, Mori, Kensaku, Oda, Hirohisa, Oda, Masahiro, Roth, Holger, Shimizu, Natsuki   +8 more
core   +1 more source

A Versatile, Portable Intravital Microscopy Platform for Studying Beta-cell Biology In Vivo [PDF]

, 2019
The pancreatic islet is a complex micro-organ containing numerous cell types, including endocrine, immune, and endothelial cells. The communication of these systems is lost upon isolation of the islets, and therefore the pathogenesis of diabetes can only
Conteh, Abass M., Day, Richard N., Dunn, Kenneth W., Kamocka, Malgorzata M., Linnemann, Amelia K., Martinez, Michelle M., Mirmira, Raghavendra G., Orr, Kara S., Piñeros, Annie R., Reissaus, Christopher A., Tersey, Sarah A., Twigg, Ashley N.   +11 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The feasibility and potential benefits of administering adjuvant chemotherapy in resected pancreatic cancer patients unable to promptly remove intraperitoneal drainage post-surgery: a retrospective cohort study

BMC Cancer
Objective Pancreatectomy remains associated with a high incidence of complications. In certain cases, patients with pancreatic ductal adenocarcinoma (PDAC) face challenges in removing intraperitoneal drainage after surgery, leading to potential delays in
Dong Xu, Nan Lv, Qianqian Wang, Yang Wu, Kai Zhang, Yi Miao, Jishu Wei, Min Tu, Kuirong Jiang   +8 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source