Results 41 to 50 of about 5,109,346 (334)
Early screening and diagnosis strategies of pancreatic cancer: a comprehensive review
Cancer Communications, 2021 Pancreatic cancer is a highly malignant digestive system tumor with a poor prognosis. Most pancreatic cancer patients are diagnosed at an advanced stage or even metastasis due to its highly aggressive characteristics and lack of typical early symptoms ...
Jinshou Yang +5 more
semanticscholar +1 more source
Hypermutation In Pancreatic Cancer [PDF]
Gastroenterology, 2017 Pancreatic cancer is molecularly diverse, with few effective therapies. Increased mutation burden and defective DNA repair are associated with response to immune checkpoint inhibitors in several other cancer types. We interrogated 385 pancreatic cancer genomes to define hypermutation and its causes. Mutational signatures inferring defects in DNA repair
Ivana Cataldo +115 more
openaire +5 more sources
Molecular Cancer, 2021 Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME).
Xiaoqi Mao +9 more
doaj +1 more source
EBioMedicine, 2022 Summary: Background: Previously, we uncovered a patient subgroup with highly malignant pancreatic cancer with serum markers CEA+/CA125+/CA19-9 ≥ 1000 U/mL (triple-positive, TP).
Longyun Ye +14 more
doaj
Surgical Case Reports, 2018 Background Surgeons sometimes must plan pancreatoduodenectomy (PD) for patients with a variant common hepatic artery (CHA) branching from the superior mesenteric artery (SMA) penetrating the pancreatic parenchyma, known as a transpancreatic CHA (tp-CHA).
Takashi Miyata +12 more
doaj +1 more source
Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer.
New England Journal of Medicine, 2019 BACKGROUND Patients with a germline BRCA1 or BRCA2 mutation make up a small subgroup of those with metastatic pancreatic cancer. The poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor olaparib has had antitumor activity in this population ...
T. Golan +18 more
semanticscholar +1 more source
Pancreatic Cancer in Chronic Pancreatitis [PDF]
Indian Journal of Surgical Oncology, 2015 Data exists to indicate a definite association between chronic pancreatitis and pancreatic cancer. The strength of this association varies between various causes of pancreatitis, with hereditary and tropical pancreatitis more likely to result in malignancy. Pathogenesis may involve genetic factors, diabetes, smoking and alcohol consumption.
Puneet Dhar, S. Kalghatgi, Vivek Saraf
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Chronic Pancreatitis and Pancreatic Cancer [PDF]
Gastroenterology, 2014 <b><i>Background:</i></b> Pancreatic cancer (PC) is one of the most lethal diseases with an incidence rate almost equal to the rate of mortality. Chronic pancreatitis (CP) is a common chronic inflammatory disease of unknown etiology that affects the pancreas.
Bai-Rong Li, Liang-Hao Hu, Zhao-Shen Li
openaire +6 more sources
Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors
World Journal of Oncology, 2019 Pancreatic cancer is the seventh leading cause of cancer-related deaths worldwide. However, its toll is higher in more developed countries. Reasons for vast differences in mortality rates of pancreatic cancer are not completely clear yet, but it may be ...
Prashanth Rawla, T. Sunkara, V. Gaduputi
semanticscholar +1 more source
BMC Cancer, 2022 Background RNA methylation refers to a form of methyl modification in RNA that modulates various epigenetic alterations. Mounting studies have focused on its potential mechanisms in cancer initiation and progression.
Siyuan Lu +9 more
doaj +1 more source