Results 51 to 60 of about 749,373 (347)

Pancreatic Cancer in Chronic Pancreatitis [PDF]

Indian Journal of Surgical Oncology, 2015
Data exists to indicate a definite association between chronic pancreatitis and pancreatic cancer. The strength of this association varies between various causes of pancreatitis, with hereditary and tropical pancreatitis more likely to result in malignancy. Pathogenesis may involve genetic factors, diabetes, smoking and alcohol consumption.
Puneet, Dhar, S, Kalghatgi, Vivek, Saraf
openaire   +2 more sources

The promising role of noncoding RNAs in cancer-associated fibroblasts: an overview of current status and future perspectives

Journal of Hematology & Oncology, 2020
As the most important component of the stromal cell population in the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) are crucial players in tumor initiation and progression. The interaction between CAFs and tumor cells, as well as the
Zengli Fang, Jin Xu, Bo Zhang, Wei Wang, Jiang Liu, Chen Liang, Jie Hua, Qingcai Meng, Xianjun Yu, Si Shi   +9 more
doaj   +1 more source

Identification of the Roles of a Stemness Index Based on mRNA Expression in the Prognosis and Metabolic Reprograming of Pancreatic Ductal Adenocarcinoma

Frontiers in Oncology, 2021
BackgroundCancer stem cells (CSCs) are widely thought to contribute to the dismal prognosis of pancreatic ductal adenocarcinoma (PDAC). CSCs share biological features with adult stem cells, such as longevity, self-renewal capacity, differentiation, drug ...
Rong Tang, Rong Tang, Rong Tang, Rong Tang, Xiaomeng Liu, Xiaomeng Liu, Xiaomeng Liu, Xiaomeng Liu, Wei Wang, Wei Wang, Wei Wang, Wei Wang, Jie Hua, Jie Hua, Jie Hua, Jie Hua, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Chen Liang, Chen Liang, Chen Liang, Chen Liang, Qingcai Meng, Qingcai Meng, Qingcai Meng, Qingcai Meng, Jiang Liu, Jiang Liu, Jiang Liu, Jiang Liu, Bo Zhang, Bo Zhang, Bo Zhang, Bo Zhang, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xianjun Yu, Si Shi, Si Shi, Si Shi, Si Shi   +43 more
doaj   +1 more source

MiRNA-145 increases therapeutic sensibility to gemcitabine treatment of pancreatic adenocarcinoma cells. [PDF]

, 2016
Pancreatic adenocarcinoma is one of the most leading causes of cancer-related deaths worldwide. Although recent advances provide various treatment options, pancreatic adenocarcinoma has poor prognosis due to its late diagnosis and ineffective therapeutic
Chen, Qiu-Dan, Ge, Xin, Jiang, Bing-Hua, Lin, Yong, Liu, Ling-Zhi, Lu, Yuan, Shi, Zhu-Mei, Wang, Min, Wen, Yiyang   +8 more
core   +2 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

m6A demethylase FTO drives pancreatic ductal adenocarcinoma tumorigenesis and metastasis through remodeling PFKM mediated glycolysis

Cell Death and Disease
N6-methyladenosine (m6A) modification has emerged as a common chemical modification in epigenetic regulation. However, whether this m6A modification is involved in glycolysis metabolism in pancreatic ductal adenocarcinoma (PDAC) remains elusive ...
Zhen Tan, Jianhui Yang, Yueyue Chen, Heng Zhu, Xiaomeng Liu, He Xu, Qingcai Meng, Mingming Xiao, Rong Tang, Zeyin Rong, Xianjun Yu, Chen Liang, Jin Xu   +12 more
doaj   +1 more source

Pevonedistat Suppresses Pancreatic Cancer Growth via Inactivation of the Neddylation Pathway

Frontiers in Oncology, 2022
BackgroundThe neddylation pathway is aberrantly overactivated in multiple human cancers and has been indicated as an effective target for anticancer therapy in clinical trials.
Junfeng Xu, Junfeng Xu, Junfeng Xu, Junfeng Xu, Zheng Li, Zheng Li, Zheng Li, Zheng Li, Qifeng Zhuo, Qifeng Zhuo, Qifeng Zhuo, Qifeng Zhuo, Zeng Ye, Zeng Ye, Zeng Ye, Zeng Ye, Guixiong Fan, Guixiong Fan, Guixiong Fan, Guixiong Fan, Heli Gao, Heli Gao, Heli Gao, Heli Gao, Shunrong Ji, Shunrong Ji, Shunrong Ji, Shunrong Ji, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xiaowu Xu, Xiaowu Xu, Xiaowu Xu, Xiaowu Xu, Wensheng Liu, Wensheng Liu, Wensheng Liu, Wensheng Liu, Wenyan Xu, Wenyan Xu, Wenyan Xu, Wenyan Xu   +43 more
doaj   +1 more source

Pancreas Cancer-Associated Weight Loss. [PDF]

, 2019
Unintentional weight loss in patients with pancreatic cancer is highly prevalent and contributes to low therapeutic tolerance, reduced quality of life, and overall mortality.
Denlinger, Crystal S, Hendifar, Andrew E, Matrisian, Lynn M, Petzel, Maria QB, Picozzi, Vincent J, Precision Promise Consortium, Rahib, Lola, Zimmers, Teresa A   +7 more
core  

SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer [PDF]

, 2017
Pancreatic cancer has a devastating prognosis, with an overall 5-year survival rate of ~8%, restricted treatment options and characteristic molecular heterogeneity.
A H Allam, A Neesse, A Neesse, A V Biankin, A Xue, AB Seymour, AD Rhim, AK Witkiewicz, AM LeBeau, AR Shekouh, AV Biankin, B Hinz, BC Ozdemir, BJ Cochran, BJ Cochran, C Gaggioli, C Vennin, D Croucher, D Goldstein, D Herrmann, D Herrmann, D Mahadevan, D N Saunders, D Telgenhoff, DD Von Hoff, DR Croucher, DR Croucher, E Cerami, F Al-Ejeh, G Finak, H Shiomi, HW Smith, I Garrido-Laguna, J Condeelis, J Gao, J Gore, J Lee, J Li, J P Morton, J R W Conway, JA Lee, JJ Lee, JP Morton, K Kessenbrock, K L Vine, L Harris, M C Lucas, M J Cowley, M Nobis, M Pajic, M Pinese, M Ranson, MJ Duffy, ML Nyström, N L E Harris, N Waddell, P Bailey, P Carmeliet, P Timpson, P Timpson, R Cicchi, R F Shearer, R Kalluri, R Smith, RF Shearer, RG Rowe, RL Siegel, S Nurmenniemi, S Ulisse, SC Barry, SR Hingorani, SR Hingorani, TK Stutchbury, WA Schroder, Y Takeuchi, ZS Boyd, Ö Babur   +76 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source