Results 51 to 60 of about 5,109,346 (334)

From the Immune Profile to the Immunoscore: Signatures for Improving Postsurgical Prognostic Prediction of Pancreatic Neuroendocrine Tumors

Frontiers in Immunology, 2021
ObjectiveImmune infiltration plays an important role in tumor development and progression and shows promising prognostic value in numerous tumors. In this study, we aimed to identify the role of immune infiltration in pancreatic neuroendocrine tumors ...
Miaoyan Wei, Miaoyan Wei, Miaoyan Wei, Miaoyan Wei, Miaoyan Wei, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Jie Hua, Jie Hua, Jie Hua, Jie Hua, Jie Hua, Qingcai Meng, Qingcai Meng, Qingcai Meng, Qingcai Meng, Qingcai Meng, Chen Liang, Chen Liang, Chen Liang, Chen Liang, Chen Liang, Jiang Liu, Jiang Liu, Jiang Liu, Jiang Liu, Jiang Liu, Bo Zhang, Bo Zhang, Bo Zhang, Bo Zhang, Bo Zhang, Wei Wang, Wei Wang, Wei Wang, Wei Wang, Wei Wang, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xianjun Yu, Si Shi, Si Shi, Si Shi, Si Shi, Si Shi   +49 more
doaj   +1 more source

FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer

New England Journal of Medicine, 2018
BACKGROUND Among patients with metastatic pancreatic cancer, combination chemotherapy with fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) leads to longer overall survival than gemcitabine therapy.
T. Conroy, P. Hammel, M. Hebbar, M. B. Abdelghani, A. Wei, J. Raoul, L. Choné, E. François, P. Artru, J. Biagi, T. Lecomte, E. Assenat, R. Faroux, M. Ychou, J. Volet, A. Sauvanet, G. Breysacher, F. Di Fioré, C. Cripps, P. Kavan, P. Texereau, K. Bouhier‐Leporrier, F. Khemissa-Akouz, J. Legoux, B. Juzyna, S. Gourgou, C. O'Callaghan, Claire Jouffroy-Zeller, P. Rat, D. Malka, F. Castan, J. Bachet   +31 more
semanticscholar   +1 more source

Worldwide Burden of, Risk Factors for, and Trends in Pancreatic Cancer.

Gastroenterology, 2020
BACKGROUND & AIMS We evaluated global and regional burdens of, risk factors for, and epidemiologic trends in pancreatic cancer among groups of different sexes and ages.
Junjie Huang, Veeleah Lok, C. Ngai, Lin Zhang, Jinqiu Yuan, X. Lao, K. Ng, C. Chong, Zhi‐Jie Zheng, M. Wong   +9 more
semanticscholar   +1 more source

Total neoadjuvant FOLFIRINOX versus neoadjuvant gemcitabine-based chemoradiotherapy and adjuvant gemcitabine for resectable and borderline resectable pancreatic cancer (PREOPANC-2 trial): study protocol for a nationwide multicenter randomized controlled trial

BMC Cancer, 2021
Neoadjuvant therapy has several potential advantages over upfront surgery in patients with localized pancreatic cancer; more patients receive systemic treatment, fewer patients undergo futile surgery, and R0 resection rates are higher, thereby possibly ...
Q. Janssen, J. L. Dam, B. Bonsing, H. Bos, K. Bosscha, P. Coene, C. H. Eijck, I. H. Hingh, T. Karsten, M. Kolk, G. Patijn, M. Liem, H. C. Santvoort, O. Loosveld, J. Vos-Geelen, B. Zonderhuis, M. Homs, G. Tienhoven, M. Besselink, J. Wilmink, B. Groot Koerkamp, for the Dutch Pancreatic Cancer Group   +21 more
semanticscholar   +1 more source

PRMT5 enhances tumorigenicity and glycolysis in pancreatic cancer via the FBW7/cMyc axis

Cell Communication and Signaling, 2019
Background The epigenetic factor protein arginine methyltransferase 5 (PRMT5) has been reported to play vital roles in a wide range of cellular processes, such as gene transcription, genomic organization, differentiation and cell cycle control.
Yi Qin, Qiangsheng Hu, Jin Xu, Shunrong Ji, Weixing Dai, Wensheng Liu, Wenyan Xu, Qiqing Sun, Zheng Zhang, Quanxing Ni, Bo Zhang, Xianjun Yu, Xiaowu Xu   +12 more
doaj   +1 more source

Turning up the heat on non-immunoreactive tumors: autophagy influences the immune microenvironment in pancreatic cancer

BMC Medical Genomics, 2022
Background Autophagy regulators play important roles in the occurrence and development of a variety of tumors and are involved in immune regulation and drug resistance.
Si-Yuan Lu, Jie Hua, Jiang Liu, Miao-Yan Wei, Chen Liang, Qing-Cai Meng, Bo Zhang, Xian Jun Yu, Wei Wang, Jin Xu   +9 more
doaj   +1 more source

The role of necroptosis in cancer biology and therapy

Molecular Cancer, 2019
Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure during cancer treatment. Bypassing the apoptotic pathway to induce cancer cell death is considered to be a promising approach to overcoming this problem ...
Yitao Gong, Zhiyao Fan, Guopei Luo, Chao Yang, Qiuyi Huang, Kun Fan, He Cheng, Kaizhou Jin, Quanxing Ni, Xianjun Yu, Chen Liu   +10 more
doaj   +1 more source

Exosomes Facilitate Therapeutic Targeting of Oncogenic Kras in Pancreatic Cancer

Nature, 2017
The mutant form of the GTPase KRAS is a key driver of pancreatic cancer but remains a challenging therapeutic target. Exosomes are extracellular vesicles generated by all cells, and are naturally present in the blood. Here we show that enhanced retention
S. Kamerkar, Valerie S. LeBleu, H. Sugimoto, Sujuan Yang, C. Ruivo, S. Melo, S. Melo, J. Lee, R. Kalluri   +8 more
semanticscholar   +1 more source

Mucins and Pancreatic Cancer [PDF]

Cancers, 2010
Pancreatic cancer is characterized by an often dramatic outcome (five year survival < 5%) related to a late diagnosis and a lack of efficient therapy. Therefore, clinicians desperately need new biomarkers and new therapeutic tools to develop new efficient therapies. Mucins belong to an ever increasing family of O-glycoproteins.
Jonckheere, Nicolas, Skrypek, Nicolas, van Seuningen, Isabelle   +2 more
openaire   +3 more sources

Novel agents for pancreatic ductal adenocarcinoma: emerging therapeutics and future directions

Journal of Hematology & Oncology, 2018
A poor prognosis of pancreatic ductal adenocarcinoma (PDAC) associated with chemoresistance has not changed for the past three decades. A multidisciplinary diagnosis followed by surgery and chemo(radiation)therapy is the main treatment approach. However,
Yiyin Zhang, Chao Yang, He Cheng, Zhiyao Fan, Qiuyi Huang, Yu Lu, Kun Fan, Guopei Luo, Kaizhou Jin, Zhengshi Wang, Chen Liu, Xianjun Yu   +11 more
doaj   +1 more source