Results 61 to 70 of about 641,720 (354)

Evidence-Based Detection of Pancreatic Canc [PDF]

, 2020
This study is an effort to develop a tool for early detection of pancreatic cancer using evidential reasoning. An evidential reasoning model predicts the likelihood of an individual developing pancreatic cancer by processing the outputs of a Support ...
Chandratre, Rajeshwari Deepak
core   +1 more source

SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival [PDF]

, 2017
Expression of the solute carrier (SLC) transporter SLC22A3 gene is associated with overall survival of pancreatic cancer patients. This study tested whether genetic variability in SLC22A3 associates with pancreatic cancer risk and prognosis.
Bambi, Franco, Campa, Daniele, Cantore, Maurizio, Canzian, Federico, Capurso, Gabriele, Delle Fave, Gianfranco, Ermini, Stefano, Fogar, Paola, Funel, Niccola, Gazouli, Maria, Giese, Nathalia, Gioffreda, Domenica, Hackert, Thilo, Holcatova, Ivana, Hughes, David J, Kala, Zdenek, Landi, Stefano, Lemstrova, Radmila, Malecka Panas, Ewa, Malleo, Giuseppe, Mambrini, Andrea, Milanetto, ANNA CATERINA, Mohelnikova Duchonova, Beatrice, Oliverius, Martin, Pazienza, Valerio, Pedata, Mariangela, Pedrazzoli, Sergio, Pezzilli, Raffaele, Piepoli, Ada, Rizzato, Cosmeri, Soucek, Pavel, Sperti, Cosimo, Strobel, Oliver, Strouhal, Ondrej, Talar Wojnarowska, Renata, Tavano, Francesca, Teresa Lawlor, Rita, Valente, Roberto, Vodicka, Pavel, Vodickova, Ludmila, Zambon, CARLO-FEDERICO   +40 more
core   +3 more sources

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Knockdown of TACC3 inhibits tumor cell proliferation and increases chemosensitivity in pancreatic cancer

Cell Death and Disease, 2023
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant digestive tract tumor with limited clinical treatments. Transforming acidic coiled-coil-containing protein 3 (TACC3) is a component of the centrosome axis and a member of the TACC family ...
Saimeng Shi, Duancheng Guo, Longyun Ye, Tianjiao Li, Qinglin Fei, Mengxiong Lin, Xianjun Yu, Kaizhou Jin, Weiding Wu   +8 more
doaj   +1 more source

Deciphering the Prognostic Implications of the Components and Signatures in the Immune Microenvironment of Pancreatic Ductal Adenocarcinoma

Frontiers in Immunology, 2021
Background: The treatment modalities for pancreatic ductal adenocarcinoma (PDAC) are limited and unsatisfactory. Although many novel drugs targeting the tumor microenvironment, such as immune checkpoint inhibitors, have shown promising efficacy for some ...
Rong Tang, Rong Tang, Rong Tang, Rong Tang, Xiaomeng Liu, Xiaomeng Liu, Xiaomeng Liu, Xiaomeng Liu, Chen Liang, Chen Liang, Chen Liang, Chen Liang, Jie Hua, Jie Hua, Jie Hua, Jie Hua, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Wei Wang, Wei Wang, Wei Wang, Wei Wang, Qingcai Meng, Qingcai Meng, Qingcai Meng, Qingcai Meng, Jiang Liu, Jiang Liu, Jiang Liu, Jiang Liu, Bo Zhang, Bo Zhang, Bo Zhang, Bo Zhang, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xianjun Yu, Si Shi, Si Shi, Si Shi, Si Shi   +43 more
doaj   +1 more source

Familial Pancreatic Cancer and the Genetics of Pancreatic Cancer

Surgical Clinics of North America, 1995
In our current understanding of pancreatic carcinoma, these neoplasms can arise either sporadically or in familial clusters. Extensive chromosome abnormalities are frequent, as is loss of heterozygosity at loci known to contain the tumor suppressor genes DCC, p53, and MTS1.
Medhat Osman, Constance A. Griffin, Jeanne A. Lumadue, Ralph H. Hruban   +3 more
openaire   +3 more sources

Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models. [PDF]

, 2014
The aim of the present study was to examine the efficacy of tumor-targeting Salmonella typhimurium A1-R treatment following anti-vascular endothelial growth factor (VEGF) therapy on VEGF-positive human pancreatic cancer.
Bouvet, Michael, Chishima, Takashi, Endo, Itaru, Hiroshima, Yukihiko, Hoffman, Robert M, Ichikawa, Yasushi, Maawy, Ali, Matsuyama, Ryusei, Miwa, Shinji, Momiyama, Masashi, Mori, Ryutaro, Murakami, Takashi, Sato, Sho, Tanaka, Kuniya, Yamamoto, Mako, Yano, Shuya, Zhang, Yong, Zhao, Ming   +17 more
core   +2 more sources

Resection rates and intention-to-treat outcomes in borderline and locally advanced pancreatic cancer: real-world data from a population-based, prospective cohort study (NORPACT-2) [PDF]

, 2023
Background: Systemic chemotherapy is the initial treatment strategy for borderline resectable and locally advanced pancreatic cancer to facilitate curative resection.
Aabakken, Lars, Dueland, Svein, Farnes, Ingvild, Fosby, Bjarte, Issa-Epe, Aart Imran, Kleive, Dyre, Labori, Knut Jørgen, Line, Pål Dag, Småstuen, Milada Cvancarova, Verbeke, Caroline Sophie   +9 more
core   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Quantifying allowable motion to achieve safe dose escalation in pancreatic SBRT [PDF]

, 2019
Tumor motion plays a key role in the safe delivery of Stereotactic Body Radiotherapy (SBRT) for pancreatic cancer. The purpose of this study was to use tumor motion data measured in patients to establish limits on motion magnitude for safe delivery of pancreatic SBRT.
arxiv   +1 more source