Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice. [PDF]
, 2019 We examined the impact of statins on Yes-associated Protein (YAP) localization, phosphorylation and transcriptional activity in human and mouse pancreatic ductal adenocarcinoma (PDAC) cells.
Chang, Hui-Hua +7 more
core +2 more sources
Approach to the Patients with Elevated CA 19-9
The Korean Journal of Gastroenterology, 2023 With the widespread adoption of health check-ups, tumor markers are being used for screening healthy individuals without symptoms related to cancer. Although CA 19-9 is known to have diagnostic value when a patient presents with symptoms, the evidence ...
Jung Wan Choe
doaj +1 more source
Sintilimab-Induced Autoimmune Diabetes in a Patient With the Anti-tumor Effect of Partial Regression
Frontiers in Immunology, 2020 ContextImmune checkpoint blockades (ICBs) have been approved widely to treat various malignancies. Autoimmune diabetes mellitus, which can be caused by programmed cell death protein 1 (PD-1) inhibitors, is rare.
Liang Wen +18 more
doaj +1 more source
Non-coding RNAs in saliva: emerging biomarkers for molecular diagnostics. [PDF]
, 2015 Saliva is a complex body fluid that comprises secretions from the major and minor salivary glands, which are extensively supplied by blood. Therefore, molecules such as proteins, DNA, RNA, etc., present in plasma could be also present in saliva.
Majem, Blanca +3 more
core +4 more sources
Evaluation of Intra-Tumoral Vascularization in Hepatocellular Carcinomas
Frontiers in Medicine, 2020 Intratumoral neovascularization has intricate effects on tumor growth, metastasis, and treatment. Over the last 30 years, Microvessel density (MVD) has been the standard method for laboratory and clinical evaluation of angiogenesis.
Qi Zhang +12 more
doaj +1 more source
Common Pancreatic Disease [PDF]
, 2010 Pancreatitis is an inflammatory disease of the pancreas characterized by acute and chronic condition as well as varying duration and severity. Acute pancreatitis (AP) is a severe abdominal inflammation, characterized by parenchymal edema, necrosis with occasional presence of pseudocysts, abscess, hemorrhage, and inflammatory cell infiltration.
openaire +2 more sources
Expression-Based Genome-Wide Association Study Links Vitamin D-Binding Protein With Autoantigenicity in Type 1 Diabetes. [PDF]
, 2016 Type 1 diabetes (T1D) is caused by autoreactive T cells that recognize pancreatic islet antigens and destroy insulin-producing β-cells. This attack results from a breakdown in tolerance for self-antigens, which is controlled by ectopic antigen expression
Butte, Atul J +9 more
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Large Animal Models in Pancreas and Biliary Disease
The Korean Journal of Gastroenterology, 2021 Rodent models, which have played important roles in preclinical research of pancreas and biliary diseases, have some limitations to translating data from rodent models to human diseases.
Seok Jeong, Jin-Seok Park, Don Haeng Lee
doaj +1 more source
Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression [PDF]
, 2017 Gastrointestinal cancer is a group of tumors that affect multiple sites of the digestive system, including the stomach, liver, colon and pancreas. These cancers are very aggressive and rapidly metastasize, thus identifying effective targets is crucial ...
Bacigalupo, Maria Lorena +2 more
core +1 more source
Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response. [PDF]
, 2015 The majority of those who drink excessive amounts of alcohol do not develop pancreatic disease. One overarching hypothesis is that alcohol abuse requires additional risk factors, either environmental or genetic, for disease to occur.
Lugea, Aurelia +2 more
core +1 more source