Results 181 to 190 of about 64,777 (328)

Copy Number of Chromosome 17 but Not HER2 Amplification Predicts Clinical Outcome of Patients With Pancreatic Ductal Adenocarcinoma [PDF]

, 2004
Nikolas H. Stoecklein, Andreas M. Luebke, Andreas Erbersdobler, Wolfram Trudo Knoefel, Winfried Schraut, Pablo Emilio Verde, Franziska Stern, P. Scheunemann, Matthias Peiper, Claus Ferdinand Eisenberger, Jakob R. Izbicki, Christoph A. Klein, Stefan B. Hosch   +12 more
openalex   +1 more source

MYC: The Guardian of Its Own Chaos

BioEssays, EarlyView.
MYC is an oncogene that drives tumorigenesis through enhanced transcription and replication. Paradoxically, MYC induces transcriptional and replicative stress and acts as a resilience factor against these stressors. We discuss how MYC balances these stressors to promote tumor growth while evading immune detection and propose strategies to target MYC ...
Abdallah Gaballa, Bastian Krenz, Leonie Uhl   +2 more
wiley   +1 more source

Global trends and epidemiological shifts in gastrointestinal cancers: insights from the past four decades

Cancer Communications, EarlyView.
Abstract Background The epidemiological profiles of gastrointestinal (GI) cancers vary across countries and over time, largely reflecting variations in risk factors and screening practices. We aimed to provide an overview of the current global burden of the five major types of GI cancers and conduct an updated evaluation of the long‐term trends of GI ...
Mengmeng Li, Sumei Cao, Rui‐Hua Xu
wiley   +1 more source

Immunosuppressive JAG2+ tumor‐associated neutrophils hamper PD‐1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells

Cancer Communications, EarlyView.
Abstract Background Tumor‐associated neutrophils (TANs) play a critical role in modulating immune responses and exhibit significant heterogeneity. Our previous study demonstrated that jagged canonical Notch ligand 2 (JAG2)+ TANs were associated with an immunosuppressive microenvironment in high‐grade serous ovarian cancer (HGSOC), but the underlying ...
Chenyang Wang, Moran Yang, Yujing Zhong, Kankan Cao, Xueling Wang, Chen Zhang, Yiying Wang, Mengdi He, Jiaqi Lu, Guodong Zhang, Yan Huang, Haiou Liu   +11 more
wiley   +1 more source

A continuous approach of modeling tumorigenesis and axons regulation for the pancreatic cancer [PDF]

arXiv
The pancreatic innervation undergoes dynamic remodeling during the development of pancreatic ductal adenocarcinoma (PDAC). Denervation experiments have shown that different types of axons can exert either pro- or anti-tumor effects, but conflicting results exist in the literature, leaving the overall influence of the nervous system on PDAC incompletely
arxiv  

Prognostic Value of VEGF in Human Pancreatic Ductal Adenocarcinoma [PDF]

, 2004
Yun Jeong Lim, Jong Kyun Lee, Cheol Keun Park, Sang Yong Song, Woo Young Jang, Hye Young Ha, Dong Il Park, Kyu Taek Lee, Seung Woon Paik, Byung Chul Yoo, Poong‐Lyul Rhee   +10 more
openalex   +1 more source

Combating cancer immunotherapy resistance: a nano‐medicine perspective

Cancer Communications, EarlyView.
Abstract Cancer immunotherapy offers renewed hope for treating this disease. However, cancer cells possess inherent mechanisms that enable them to circumvent each stage of the immune cycle, thereby evading anti‐cancer immunity and leading to resistance.
Xiangyi Kong, Xintong Xie, Juan Wu, Xiangyu Wang, Wenxiang Zhang, Shuowen Wang, Daria Valerievna Abbasova, Yi Fang, Hongnan Jiang, Jidong Gao, Jing Wang   +10 more
wiley   +1 more source

Opportunistic Screening for Pancreatic Cancer using Computed Tomography Imaging and Radiology Reports [PDF]

arXiv
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer, with most cases diagnosed at stage IV and a five-year overall survival rate below 5%. Early detection and prognosis modeling are crucial for improving patient outcomes and guiding early intervention strategies.
arxiv  

Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor

Cancer Communications, EarlyView.
Abstract Neutrophils are important components of the immune system and play a key role in defending against pathogenic infections and responding to inflammatory cues, including cancer. Their dysregulation indicates potential disease risk factors. However, their functional importance in disease progression has often been underestimated due to their ...
Wenpeng Cai, Tao Fan, Chu Xiao, Ziqin Deng, Yixiao Liu, Chunxiang Li, Jie He   +6 more
wiley   +1 more source

Small Pancreatic Ductal Adenocarcinoma Arising from Peripheral Side Branch : A Report of Case

, 1994
Yasuo Okada, J Ariyama, Masafumi Suyama, Kaoru Ogawa, Kazuhiro Satou, Jirou Nagaiwa, Jinkan Sai, Yoshihiro Kubokawa, Kouichirou Yamanaka, Kaori Wakabayashi, Shingo Asahara, Keigo Kinoshita   +11 more
openalex   +2 more sources