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Association of immunohistochemical expression of thrombin, PAR-1 and tumor budding in pancreatic ductal adenocarcinoma

Anteja Krištić
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The immunological landscape in pancreatic ductal adenocarcinoma and overcoming resistance to immunotherapy.

The Lancet Gastroenterology and Hepatology, 2023
Pancreatic ductal adenocarcinoma is associated with a poor prognosis and there are few treatment options. The development of immunotherapy in pancreatic ductal adenocarcinoma has been difficult, and immune checkpoint inhibitors are only effective in a ...
M. Hilmi, M. Delaye, M. Muzzolini, R. Nicolle, Jérôme Cros, Pascal Hammel, Victoire Cardot-Ruffino, C. Neuzillet   +7 more
semanticscholar   +1 more source

Artificial Intelligence to Predict Lymph Node Metastasis at CT in Pancreatic Ductal Adenocarcinoma.

Radiology, 2022
Background Although deep learning has brought revolutionary changes in health care, reliance on manually selected cross-sectional images and segmentation remain methodological barriers. Purpose To develop and validate an automated preoperative artificial
Yun Bian, Zhilin Zheng, Xu Fang, Huiyan Jiang, Mengmeng Zhu, Jieyu Yu, Hai Zhao, Ling Zhang, Jiawen Yao, Le Lu, Jianping Lu, C. Shao   +11 more
semanticscholar   +1 more source

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice.

Cancer Cell, 2005
To define the genetic requirements for pancreatic ductal adenocarcinoma (PDA), we have targeted concomitant endogenous expression of Trp53(R172H) and Kras(G12D) to the mouse pancreas, revealing the cooperative development of invasive and widely ...
S. Hingorani, Lifu Wang, A. Multani, C. Combs, T. Deramaudt, R. Hruban, A. Rustgi, Sandy Chang, D. Tuveson   +8 more
semanticscholar   +1 more source

Immunotherapy for pancreatic ductal adenocarcinoma

Journal of Surgical Oncology, 2021
AbstractPancreatic ductal adenocarcinoma (PDAC) remains a lethal cancer with an urgent need for better medical therapies. Efforts have been made to investigate the efficacy of immunotherapy, particularly given the hallmarks of immune suppression and exhaustion in PDAC tumors.
Eileen Carpenter, Sarah Nelson, Filip Bednar, Clifford Cho, Hari Nathan, Vaibhav Sahai, Marina Pasca di Magliano, Timothy L. Frankel   +7 more
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Microbiome and pancreatic ductal adenocarcinoma

Clinics and Research in Hepatology and Gastroenterology, 2021
Pancreatic ductal adenocarcinoma (PDAC) incidence and related-deaths are increasing worldwide. PDAC is characterized by poor prognosis due to late diagnosis, high metastatic capacity and resistance to therapy. This is partially due to its specific microenvironment, where the stroma is prominent over tumor cells. Besides the oral and gut microbiota, the
Annemilaï Tijeras-Raballand, Marc Hilmi, Lucile Astorgues-Xerri, Rémy Nicolle, Ivan Bièche, Cindy Neuzillet   +5 more
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Aquaporins in pancreatic ductal adenocarcinoma

APMIS, 2021
Aquaporins are water channel proteins facilitating passive transport of water across cellular membranes. Aquaporins are over‐ or ectopically expressed in a multitude of cancers, including pancreatic ductal adenocarcinoma, which is a highly aggressive cancer with low survival rate. Evidence suggests that aquaporins can affect multiple cellular processes
Bruun-Sørensen, Anne Sofie, E, Sarannya, Login, Frédéric H., Borgquist, Signe, Nejsum, Lene Niemann   +4 more
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Pancreatic ductal adenocarcinoma: metastatic disease

Clinical and Translational Oncology, 2017
The treatment of choice of metastatic PADC is systemic chemotherapy. In the last decade, there have been significant advances in this area. New combination poli-chemotherapy schemes have shown a significant increase in overall survival and progression-free survival without impairing quality of life.
A. J. Muñoz Martín, J. Adeva, J. Martínez-Galán, J. J. Reina, M. Hidalgo   +4 more
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