Results 71 to 80 of about 433,923 (290)
Pancreatic Ductal Adenocarcinoma Associated with Autoimmune Pancreatitis [PDF]
Case Reports in Gastroenterology, 2011 Autoimmune pancreatitis (AIP), in contrast to other benign chronic pancreatic diseases, can be cured with immunosuppressant drugs, thus the differentiation of AIP from pancreatic cancer is of particular interest in clinical practice. There is the possibility that some patients with AIP may develop pancreatic cancer, and this possibility contributes to ...
Pezzilli R +9 more
openaire +4 more sources
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Identification of a novel subpopulation of tumor-initiating cells from gemcitabine-resistant pancreatic ductal adenocarcinoma patients. [PDF]
PLoS ONE, 2013 Pancreatic ductal adenocarcinoma is highly resistant to systemic chemotherapy. Although there are many reports using pancreatic cancer cells derived from patients who did not receive chemotherapy, characteristics of pancreatic cancer cells from ...
Kazuya Shimizu +2 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar +2 more
wiley +1 more source
Pictorial Review of Rare Pancreatic Tumors and Tumor-Like Lesions
대한영상의학회지, 2020 Various types of tumors and tumor-like lesions may affect the pancreas. Among them, pancreatic ductal adenocarcinoma is the most common and is generally referred to as “pancreatic cancer.” Recently, the detection rates of rare pancreatic tumors and ...
Seung Jae Lee +3 more
doaj +1 more source
Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability. [PDF]
PLoS ONE, 2017 Pancreatic ductal adenocarcinoma, which accounts for the majority of pancreatic cancers, is a lethal disease with few therapeutic options. Genomic profiling of pancreatic ductal adenocarcinoma has identified a complex and heterogeneous landscape ...
Jeran K Stratford +6 more
doaj +1 more source
Risk of pancreatic ductal adenocarcinoma in chronic pancreatitis [PDF]
Gut, 2002 Patients with chronic pancreatitis have a markedly increased risk of pancreatic cancer compared with the general population Chronic pancreatitis has been proposed as an independent risk factor for the development of pancreatic cancer in a number of important studies.1–3 Problems with methodology however, such as patient selection, ascertainment bias ...
N, Howes, J P, Neoptolemos
openaire +2 more sources
Advanced Materials Technologies, EarlyView.Desktop vacuum thermoforming enables rapid, low‐cost fabrication of 96‐channel polystyrene culture chips with very thin imaging interfaces. The resulting platform supports cell lines, primary cells, and patient‐derived organoids, and enables high‐resolution confocal microscopy and single‐cell visualization, providing an accessible approach for advanced
Aleksandra Fomina +5 more
wiley +1 more source
Antineoplastic effects of auranofin in human pancreatic adenocarcinoma preclinical models
Surgery Open Science, 2019 Background: Auranofin, a Food and Drug Administration–approved anti-rheumatic agent with anticancer properties for lung and ovarian cancer, has never been studied for pancreatic cancer.
Mayrim V. Rios Perez +10 more
doaj +1 more source
The dark side of ferroptosis in pancreatic cancer
OncoImmunology, 2021 Drug-induced ferroptosis, an iron-dependent regulatory necrosis, has been proposed for the therapy of pancreatic ductal adenocarcinoma. However, genetically engineered mouse models have revealed that high-iron diets or deletion of pancreatic GPX4 (a key ...
Jiao Liu +4 more
doaj +1 more source