Results 71 to 80 of about 84,228 (303)

Antineoplastic effects of auranofin in human pancreatic adenocarcinoma preclinical models

Surgery Open Science, 2019
Background: Auranofin, a Food and Drug Administration–approved anti-rheumatic agent with anticancer properties for lung and ovarian cancer, has never been studied for pancreatic cancer.
Mayrim V. Rios Perez, David Roife, Bingbing Dai, Michael Pratt, Ryszard Dobrowolski, Ya'an Kang, Xinqun Li, Jithesh J. Augustine, Rafal Zielinski, Waldemar Priebe, Jason B. Fleming   +10 more
doaj   +1 more source

The dark side of ferroptosis in pancreatic cancer

OncoImmunology, 2021
Drug-induced ferroptosis, an iron-dependent regulatory necrosis, has been proposed for the therapy of pancreatic ductal adenocarcinoma. However, genetically engineered mouse models have revealed that high-iron diets or deletion of pancreatic GPX4 (a key ...
Jiao Liu, Enyong Dai, Rui Kang, Guido Kroemer, Daolin Tang   +4 more
doaj   +1 more source

Mixed pancreatic acinar cell-ductal adenocarcinoma: Complexities in diagnosis and treatment

Current Problems in Cancer: Case Reports, 2022
Background: Acinar cell carcinoma of the pancreas (ACC) is a rare malignancy, accounting for approximately 1-2% of all pancreatic cancers. Up to a quarter of ACCs are estimated to contain a significant component of another histology such as ...
Abdullah Nasser, Catherine L. Forse, Cynthia Walsh, Terence Moyana, Rakesh Goel   +4 more
doaj   +1 more source

Pancreatic Ductal Adenocarcinoma Associated with Autoimmune Pancreatitis [PDF]

Case Reports in Gastroenterology, 2011
Autoimmune pancreatitis (AIP), in contrast to other benign chronic pancreatic diseases, can be cured with immunosuppressant drugs, thus the differentiation of AIP from pancreatic cancer is of particular interest in clinical practice. There is the possibility that some patients with AIP may develop pancreatic cancer, and this possibility contributes to ...
Pezzilli R, Vecchiarelli S, Di Marco MC, Serra C, SANTINI, DAVIDE, Calculli L, FABBRI, DARIO, Rojas Mena B, Imbrogno A, Source Pancreas Unit Department of Digestive Diseases and Internal Medicine University of Bologna Bologna Italy.   +9 more
openaire   +4 more sources

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Pancreatic-Polypeptide in the Human Pancreas: Expression and Quantitative Variation During Development and in Ductal Adenocarcinoma

Acta Medica, 2003
Aim: To determine the immunoreactivity of pancreatic-polypeptide (PP) during the development of the human fetal pancreas and ductal pancreatic adenocarcinoma, given that, PP positive cells were demonstrated either into its embryonic anlage or into ...
Demetrio Tamiolakis, Constantine Simopoulos, Athanasia Kotini, Ioannis Venizelos, Theodoros Jivannakis, Nikolaos Papadopoulos   +5 more
doaj   +1 more source

Risk of pancreatic ductal adenocarcinoma in chronic pancreatitis [PDF]

Gut, 2002
Patients with chronic pancreatitis have a markedly increased risk of pancreatic cancer compared with the general population Chronic pancreatitis has been proposed as an independent risk factor for the development of pancreatic cancer in a number of important studies.1–3 Problems with methodology however, such as patient selection, ascertainment bias ...
N, Howes, J P, Neoptolemos
openaire   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Sonic Hedgehog Ligand: A Role in Formation of a Mesenchymal Niche in Human Pancreatic Ductal Adenocarcinoma

, 2019
Pancreatic ductal adenocarcinoma (PDAC) is characterised by desmoplasia, thought to support progression and chemotherapeutic resistance. The Hedgehog pathway is known to play an important role in this cancer. While the upregulation of Sonic hedgehog (Shh)
Saini, Francesca, Argent, Richard H., Richard H. Argent, Richard H. Argent, Anna M. Grabowska, Anna M. Grabowska, Grabowska, Anna, Francesca Saini   +7 more
core   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source