Results 51 to 60 of about 84,228 (303)

Adapting cellular riboflavin transport and metabolism in pancreatic ductal adenocarcinoma

, 2022
Riboflavin (Rf) is an essential dietary component and is the precursor of FMN and FAD, the redox enzymatic cofactors required for mitochondrial terminal metabolism 1.
Maria Tolomeo, Maria Squicciarino, Maria Barile, Alessia Nisco, Tiago Carvalho, Daria Di Molfetta   +5 more
core  

Solitary metastasis to the head of the pancreas from lung adenocarcinoma mimicking pancreatic ductal adenocarcinoma: A case report

Radiology Case Reports
Solitary pancreatic metastasis is a rare cause of pancreatic neoplasm. Pancreatic ductal adenocarcinoma is the primary differential consideration when a solitary pancreatic mass is diagnosed, as it is the most common solitary solid pancreatic neoplasm. A
Mostafa Amor, M. Azfar Siddiqui, Irfan Amir Kazi, Asad Kabir, Ayesha Nasrullah   +4 more
doaj   +1 more source

Mass-Forming Chronic Pancreatitis: Diagnostic Performance of PET/CT

World Journal of Nuclear Medicine, 2022
Mass-forming chronic pancreatitis and pancreatic ductal adenocarcinoma are most commonly located in the head of pancreas, and there is a marked overlap in clinical features and imaging findings that makes it diagnostically challenging, although prognosis
Ravikanth Reddy
doaj   +1 more source

Molecular Analysis of Precursor Lesions in Familial Pancreatic Cancer

, 2013
PMCID: PMC3553106This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Stipo Jurcevic (276415), Bhakta Vipul, Bronner, Mary, Harada, Tomohiko, Barry Sayka, Bronner, M, Mary Bronner (276416), Lattimore Sam, Lemoine Nicholas R., Tomohiko Harada, Teresa A Brentnall, Crnogorac-Jurcevic, Tatjana, Claude Chelala, Brentnall, TA, Mary Bronner, Sam Lattimore (276414), Lattimore, Sam, Tatjana Crnogorac-Jurcevic (57627), Brentnall, Teresa A, Bhakta, V, Crnogorac-Jurcevic, T, Bronner Mary, Teresa A. Brentnall (186815), Chelala, C, Nicholas R. Lemoine (276417), Jurcevic, Stipo, Barry, Sayka, Brentnall Teresa A., Sam Lattimore, Crnogorac-Jurcevic Tatjana, Lemoine, Nicholas R, Lemoine, NR, Lattimore, S, Jurcevic Stipo, Nicholas R Lemoine, Sayka Barry, Tomohiko Harada (276412), Chelala Claude, Harada, T, Stipo Jurcevic, Barry, S, Vipul Bhakta (276413), Chelala, Claude, Jurcevic, S, Bhakta, Vipul, Vipul Bhakta, Sayka Barry (57623), Tatjana Crnogorac-Jurcevic, Claude Chelala (3016), Harada Tomohiko   +49 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

The anti-tumor effect of HDAC inhibition in a human pancreas cancer model is significantly improved by the simultaneous inhibition of cyclooxygenase 2. [PDF]

PLoS ONE, 2013
Pancreatic ductal adenocarcinoma is the fourth leading cause of cancer death worldwide, with no satisfactory treatment to date. In this study, we tested whether the combined inhibition of cyclooxygenase-2 (COX-2) and class I histone deacetylase (HDAC ...
Olivier Peulen, Arnaud Gonzalez, Paul Peixoto, Andrei Turtoi, Denis Mottet, Philippe Delvenne, Vincent Castronovo   +6 more
doaj   +1 more source

Cost-effectiveness of diagnostic laparoscopy for assessing resectability in pancreatic and periampullary cancer.

, 2015
Surgical resection is the only curative treatment for pancreatic and periampullary cancer, but many patients undergo unnecessary laparotomy because tumours can be understaged by computerised tomography (CT).
Morris, S, Gurusamy, KS, Davidson, BR, Kurinchi S Gurusamy, Stephen Morris, Sheringham, J, Brian R Davidson, Jessica Sheringham   +7 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression

Nature Communications, 2022
The advent of immunotherapy has revolutionised cancer therapeutics, but its application in the context of pancreatic ductal adenocarcinoma has been limited.
Anne E. Geller, Rejeena Shrestha, Matthew R. Woeste, Haixun Guo, Xiaoling Hu, Chuanlin Ding, Kalina Andreeva, Julia H. Chariker, Mingqian Zhou, David Tieri, Corey T. Watson, Robert A. Mitchell, Huang-ge Zhang, Yan Li, Robert C. G. Martin II, Eric C. Rouchka, Jun Yan   +16 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source