Results 31 to 40 of about 84,228 (303)
MicroRNA-Regulated Signaling Pathways: Potential Biomarkers for Pancreatic Ductal Adenocarcinoma [PDF]
, 2021 Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive and invasive type of pancreatic cancer (PCa) and is expected to be the second most common cause of cancer-associated deaths.
Uysal Onganer, P. +5 more
core +1 more source
Molecular Therapy: Nucleic Acids, 2022 This research developed an easy-to-use, reproducible pancreatic cancer animal model utilizing pancreas-targeted hydrodynamic gene delivery to deliver human pancreatic cancer-related genes to the pancreas of wild-type rats.
Osamu Shibata +12 more
doaj +1 more source
An Immunological Glance on Pancreatic Ductal Adenocarcinoma [PDF]
International Journal of Molecular Sciences, 2020 Pancreatic ductal adenocarcinoma (PDAC) has still a dismal prognosis. Different factors such as mutational landscape, intra- and intertumoral heterogeneity, stroma, and immune cells impact carcinogenesis of PDAC associated with an immunosuppressive microenvironment. Different cell types with partly opposing roles contribute to this milieu.
Michael Karl Melzer +7 more
openaire +2 more sources
The Roles of Frequently Mutated Genes of Pancreatic Cancer in Regulation of Tumor Microenvironment
Technology in Cancer Research & Treatment, 2020 Pancreatic ductal adenocarcinoma has extremely high malignancy and patients with pancreatic ductal adenocarcinoma have dismal prognosis. The failure of pancreatic ductal adenocarcinoma treatment is largely due to the tumor microenvironment, which is ...
Hongzhi Sun MMed +2 more
doaj +1 more source
Inhibiting CDK4/6 in pancreatic ductal adenocarcinoma via microRNA-21 [PDF]
, 2023 Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies, with a 5-year survival rate of 5–10 %. The high mortality rate is due to the asymptomatic progression of clinical features in metastatic stages of the disease, which ...
Uysal Onganer, P. +4 more
core +1 more source
Mimics of pancreatic ductal adenocarcinoma [PDF]
Cancer Imaging, 2013 Several uncommon primary pancreatic tumors, inflammatory conditions, metastasis to the pancreas and peripancreatic masses can mimic the appearance of pancreatic ductal adenocarcinoma (PDA). Differentiation between these lesions and PDA can be challenging, due to the overlap in imaging features; however, familiarity with their typical imaging features ...
Al-Hawary, Mahmoud M. +4 more
openaire +2 more sources
Journal of Translational Medicine, 2019 Background A hallmark of pancreatic ductal adenocarcinoma is the desmoplastic reaction, but its impact on the tumor behavior remains controversial.
Fabio Grizzi +18 more
doaj +1 more source
Desmoplasia of Pancreatic Ductal Adenocarcinoma [PDF]
Clinical Gastroenterology and Hepatology, 2009 Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer and is characterized by remarkable desmoplasia. The desmoplasia is composed of extracellular matrix (ECM) proteins, myofibroblastic pancreatic stellate cells, and immune cells associated with a multitude of cytokines, growth factors, and ECM metabolizing enzymes.
Stephen, Pandol +4 more
openaire +2 more sources
Human Pathology: Case Reports, 2019 Pancreatic ductal adenocarcinoma is a very aggressive neoplasm with a low survival rate, comprising the majority of pancreatic malignancies. Psammoma bodies have rarely been reported in pancreatic ductal adenocarcinoma, and their clinicopathologic ...
Hongxing Gui +3 more
doaj +1 more source
Multimodal Treatment Eliminates Cancer Stem Cells and Leads to Long-Term Survival in Primary Human Pancreatic Cancer Tissue Xenografts. [PDF]
, 2013 Copyright: 2013 Hermann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Tunici, P +51 more
core +1 more source