Results 21 to 30 of about 433,923 (290)

Carcinogenesis of Pancreatic Ductal Adenocarcinoma [PDF]

Gastroenterology, 2020
Although the estimated time for development of pancreatic ductal adenocarcinoma (PDA) is more than 20 years, PDAs are usually detected at late, metastatic stages. PDAs develop from duct-like cells through a multistep carcinogenesis process, from low-grade dysplastic lesions to carcinoma in situ and eventually to metastatic disease.
Peter, Storz, Howard C, Crawford
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Desmoplasia of Pancreatic Ductal Adenocarcinoma [PDF]

Clinical Gastroenterology and Hepatology, 2009
Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer and is characterized by remarkable desmoplasia. The desmoplasia is composed of extracellular matrix (ECM) proteins, myofibroblastic pancreatic stellate cells, and immune cells associated with a multitude of cytokines, growth factors, and ECM metabolizing enzymes.
Stephen, Pandol, Mouad, Edderkaoui, Ilya, Gukovsky, Aurelia, Lugea, Anna, Gukovskaya   +4 more
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Familial Pancreatic Ductal Adenocarcinoma [PDF]

The American Journal of Pathology, 2019
Pancreatic ductal adenocarcinoma (PDAC), although a rare disease, has a poor prognosis. With 5-year overall survival of 8%, there is a critical need to detect PDAC early or at a premalignant stage. Current screening methods are largely imaging based, but a more focused screening approach based on modifiable and nonmodifiable risk factors may improve ...
Kelly E, Diaz, Aimee L, Lucas
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An Immunological Glance on Pancreatic Ductal Adenocarcinoma [PDF]

International Journal of Molecular Sciences, 2020
Pancreatic ductal adenocarcinoma (PDAC) has still a dismal prognosis. Different factors such as mutational landscape, intra- and intertumoral heterogeneity, stroma, and immune cells impact carcinogenesis of PDAC associated with an immunosuppressive microenvironment. Different cell types with partly opposing roles contribute to this milieu.
Michael Karl Melzer, Frank Arnold, Katja Stifter, Friedemann Zengerling, Ninel Azoitei, Thomas Seufferlein, Christian Bolenz, Alexander Kleger   +7 more
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Mimics of pancreatic ductal adenocarcinoma [PDF]

Cancer Imaging, 2013
Several uncommon primary pancreatic tumors, inflammatory conditions, metastasis to the pancreas and peripancreatic masses can mimic the appearance of pancreatic ductal adenocarcinoma (PDA). Differentiation between these lesions and PDA can be challenging, due to the overlap in imaging features; however, familiarity with their typical imaging features ...
Al-Hawary, Mahmoud M., Kaza, Ravi K., Azar, Shadi F., Ruma, Julie A., Francis, Isaac R.   +4 more
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Tumour–stroma interactions in an organotypic culture model of pancreatic cancer [PDF]

, 2011
PhDPancreatic cancer is characterised by an intense fibrotic, or desmoplastic, stroma, which contributes to tumour progression. Three-dimensional in vitro culture models incorporating this non-tumour component may more closely recapitulate the ...
Froeling, Fieke E.M.
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microRNA-21 Regulates Stemness in Pancreatic Ductal Adenocarcinoma Cells [PDF]

, 2022
Pancreatic ductal adenocarcinoma (PDAC) is the most common and aggressive type of pancreatic cancer (PCa) with a low survival rate. microRNAs (miRs) are endogenous, non-coding RNAs that moderate numerous biological processes.
Uysal Onganer, P., Jurcevic, S., Alwyn Dart, Dart, A, Mortoglou, M., Arisan, E.D., Pinar Uysal-Onganer, Francesc Miralles, Dart, A., Sigrun Lange, Lange, S, Lange, S., Mortoglou, M, Stipo Jurcevic, Arisan, ED, Miralles, F., Elif Damla Arisan, Jurcevic, S, Miralles, F, Maria Mortoglou, Uysal-Onganer, P   +20 more
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Pancreatic resections for advanced M1-pancreatic carcinoma : the value of synchronous metastasectomy [PDF]

, 2010
Background: For M1 pancreatic adenocarcinomas pancreatic resection is usually not indicated. However, in highly selected patients synchronous metastasectomy may be appropriate together with pancreatic resection when operative morbidity is low ...
Chromik, Ansgar Michael, M. H. Seelig, A. M. Chromik, Tannapfel, Andrea, Seelig, Mathias H., S. K. Seelig, Seelig, Stefanie Katharina, Burkert, Björn, Uhl, Waldemar, A. Tannapfel, B. Burkert, W. Uhl   +11 more
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Significance of High-Mobility Group A Protein 2 Expression in Pancreatic Ductal Adenocarcinoma and Ampullary Adenocarcinoma

, 2023
BACKGROUND/AIMS: Pancreatic and ampullary adenocarcinoma (AAC) are quite resistant to chemotherapy with high metastasis potential. Our study aimed to interpret high-mobility group A protein 2 (HMGA2) expression in benign and precursor pancreatic lesions ...
Demir, Lütfiye, Oflas, Damla, Ertuğrul Çolak, Funda Canaz, Çolak, Ertuğrul, Damla Oflas, İlter Özer, Lütfiye Demir, Özer, İlter, Canaz, Funda   +9 more
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Multimodal Treatment Eliminates Cancer Stem Cells and Leads to Long-Term Survival in Primary Human Pancreatic Cancer Tissue Xenografts. [PDF]

, 2013
Copyright: 2013 Hermann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Tunici, P, Stephan A. Hahn (423002), Hidalgo Manuel, Annette Bakker (109705), Trabulo Sara M., Hermann, PC, Hahn, SA, Patrizia Tunici (109691), Patrick C. Hermann, Hahn Stephan A., Vandana, M, Sanjeeb K. Sahoo (176483), Sahoo Sanjeeb K., Sainz, B, Sainz Bruno, Anamaria Balic (423000), Garcia Elena, Tunici Patrizia, Manuel Hidalgo, Balic, A, Balic Anamaria, Stephan A. Hahn, Vandana Mallaredy, Elena Garcia (423001), Stephan A Hahn, Christopher Heeschen (373899), Sahoo, SK, Patrizia Tunici, Bakker Annette, Mallaredy Vandana, Heeschen Christopher, Patrick C Hermann, Bruno Sainz, Sara M Trabulo, Sara M. Trabulo, Christopher Heeschen, Patrick C. Hermann (422997), Garcia, E, Mallaredy Vandana (423003), Elena Garcia, Sanjeeb K Sahoo, Heeschen, C, Manuel Hidalgo (7235), Bakker, A, Bruno Sainz Jr (422999), Sanjeeb K. Sahoo, Hermann Patrick C., Sara M. Trabulo (422998), Trabulo, SM, Anamaria Balic, Hidalgo, M, Annette Bakker   +51 more
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