Randomized phase III trial of intravenous and intraperitoneal paclitaxel with S-1 versus gemcitabine plus nab-paclitaxel for pancreatic ductal adenocarcinoma with peritoneal metastasis (SP study) [PDF]
Tomohisa Yamamoto +18 more
openalex +1 more source
Netrin‐1 expression is upregulated in hepatic stellate cells (HSCs) during metabolic dysfunction–associated steatohepatitis and injury‐mediated liver fibrosis. Secreted Netrin‐1 establishes an autocrine positive feedback loop by binding to UNC5B receptors on HSCs.
Jiahui Zhao +8 more
wiley +1 more source
Idiopathic pancreatitis comprises of around 20% cases of acute pancreatitis. We report a case with reversed Z-type main pancreatic duct, a very rare and unusual anomaly of the main pancreatic duct as a cause for idiopathic acute pancreatitis. A review of
Amarnath Kadimella +2 more
doaj +1 more source
Improved outcomes with minimally invasive pancreaticoduodenectomy in patients with dilated pancreatic ducts: a prospective study. [PDF]
Cos H +14 more
europepmc +1 more source
GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer
Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh +8 more
wiley +1 more source
Discovery and 3D imaging of a novel ΔNp63-expressing basal cell type in human pancreatic ducts with implications in disease. [PDF]
Martens S +25 more
europepmc +1 more source
Invasive Adenoarcinoma Arising in Mucinous Cystic Neoplasm Communicating to Main Pancreatic Duct with Concurrent Pseudocyst: A Report of Very Rare Case [PDF]
Dinesh Kumar +3 more
openalex +1 more source
Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira +18 more
wiley +1 more source

