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Suizo, 2007 膵内外分泌不全の病態を正しく理解し，十分な食事療法（膵炎食ではない）に加え，膵性脂肪便をはじめとする消化吸収不良を膵酵素製剤の補充によって治療する．更に，膵性糖尿病の血糖コントロールを自己血糖測定下に超速効型インスリン，持効型（中間型）インスリンを組み合わせることによって患者のQuality of life及び予後は著しく改善してきた．しかし，新しいインスリン製剤によってより良い血糖コントロールが，糖尿病固有の最小血管障害（腎症）の進行をどの程度抑制するかについての臨床データはまだ存在していない．
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Pancreatic enzyme replacement therapy in malabsorption of pancreatic, hepatic, and gastric origin
The American Journal of Digestive Diseases, 1962Malabsorption on a basis of pancreatico-hepatic disease is more common than usually considered. The symptoms of this type of malabsorption are usually not diarrhea, but may be more those of general weakness, flatulence, anorexia, weight loss, and abdominal discomfort.
F, STEIGMANN, D, SNYDER, A, FERNANDEZ
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The Role of Pancreatic Enzyme Replacement Therapy in Unresectable Pancreatic Cancer
Pancreas, 2017Although patients with pancreatic cancer (PC) are prone to exocrine pancreatic insufficiency, there are little evidence about pancreatic enzyme replacement therapy (PERT) in patients with PC, especially those receiving chemotherapy.This is a prospective consecutive observational study of PERT in patients with unresectable PC.
Tomotaka, Saito +17 more
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Pancreatic enzyme-replacement therapy in CF: considerations for the USA
Expert Review of Respiratory Medicine, 2008Pancreatic enzyme products (PEPs) have been commercially available since before the passage of the Food, Drug and Cosmetic Act in 1938. They are a vital therapy for patients with cystic fibrosis and exocrine pancreatic insufficiency. PEPs help to enhance absorption of nutrients and thereby play an important role in maintaining good nutritional status ...
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Digestive Diseases, 2010
In chronic pancreatitis over a course of years to decades, pancreatic parenchyma is gradually lost and pain is gradually decreasing as signs and symptoms of malabsorption appear. Appearance of calcifications is a late sign and in many cases coincides with appearance of steatorrhea. Decreasing output of insulin and glucagon results in diabetes mellitus,
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In chronic pancreatitis over a course of years to decades, pancreatic parenchyma is gradually lost and pain is gradually decreasing as signs and symptoms of malabsorption appear. Appearance of calcifications is a late sign and in many cases coincides with appearance of steatorrhea. Decreasing output of insulin and glucagon results in diabetes mellitus,
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Pancreatic enzyme replacement therapy in chronic pancreatitis: a long way to go
Gut, 2017Pancreatic exocrine insufficiency (PEI) in chronic pancreatitis (CP) is underdiagnosed and undertreated. An important and expertly conducted meta-analysis in this issue examines the efficacy of pancreatic enzyme replacement therapy (PERT) in patients with CP.1 The key findings are that PERT increases fat and protein absorption and does so more ...
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BMJ Supportive & Palliative Care, 2014
PurposeThe diagnosis of metastatic pancreatic cancer (PC) carries a poor prognosis. PC is associated with weight loss and malabsorption in high rates secondary to pancreatic exocrine insufficiency. UK and USA guidelines exist recommending the empiric use of pancreatic enzyme replacement therapy (PERT) for quality of life in these patients.
Amanda, Landers +2 more
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PurposeThe diagnosis of metastatic pancreatic cancer (PC) carries a poor prognosis. PC is associated with weight loss and malabsorption in high rates secondary to pancreatic exocrine insufficiency. UK and USA guidelines exist recommending the empiric use of pancreatic enzyme replacement therapy (PERT) for quality of life in these patients.
Amanda, Landers +2 more
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Pancreatic enzymes replacement therapy in chronic pancreatitis: an update.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 2002Chronic pancreatitis is the major cause of exocrine pancreatic insufficiency which should be compensated by pancreatic enzyme replacement therapy. There are now available a great number of pancreatic enzyme preparations, but encapsulated enteric-coated microspheres and minimicrospheres are considered the enzyme treatment of choice.
A, Trifan, G, Balan, C, Stanciu
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Digestive Enzyme Replacement Therapy: Pancreatic Enzymes and Lactase.
Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses, 2017Maldigestion occurs when digestive enzymes are lacking to help break complex food components into absorbable nutrients within the gastrointestinal tract. Education is needed to help patients manage the intricacies of digestive enzyme replacement therapies and ensure their effectiveness in reducing symptoms of maldigestion.
Rhea Faye D, Felicilda-Reynaldo +1 more
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Topics in Clinical Pharmacology: Pancreatic Enzyme Replacement Therapy
The American Journal of the Medical Sciences, 1989A number of pancreatic enzyme replacement agents are currently available for correction of pancreatic insufficiency. All are derivatives of pancrelipase derived from hog pancreas and contain lipase, amylase, and protease. Pancrelipase preparations exist in two major forms.
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