Results 41 to 50 of about 20,714 (241)

Exocrine pancreatic insufficiency in systemic diseases: unravelling the complex interplay – a comprehensive review

Polish Journal of Pathology
Exocrine pancreatic insufficiency (EPI) is characterised by the pancreas’s inadequate synthesis or release of digestive enzymes, which impairs digestion and causes nutritional malabsorption.
Muhammad Ali Muzammil, Laiba Imran, Jatin Motwani, Mariam Anwar, Sania Riaz, Namra Vinay Gohil, Fariha ., Aarfeen .   +7 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Novel GATA6 mutations in patients with pancreatic agenesis and congenital heart malformations.

PLoS ONE, 2015
Patients with pancreatic agenesis are born without a pancreas, causing permanent neonatal diabetes and pancreatic enzyme insufficiency. These patients require insulin and enzyme replacement therapy to survive, grow, and maintain normal blood glucose ...
Christina S Chao, Kristen D McKnight, Kenneth L Cox, Anne L Chang, Seung K Kim, Brian J Feldman   +5 more
doaj   +1 more source

Severe Genotype, Pancreatic Insufficiency and Low Dose of Pancreatic Enzymes Associate with Abnormal Serum Sterol Profile in Cystic Fibrosis

Biomolecules, 2021
Background: Several factors could lead to lipid disturbances observed in cystic fibrosis (CF). This study aimed to assess sterol homeostasis in CF and define potential exogenous and endogenous determinants of lipid dysregulation.
Sławomira Drzymała-Czyż, Patrycja Krzyżanowska-Jankowska, Krzysztof Dziedzic, Aleksandra Lisowska, Szymon Kurek, Joanna Goździk-Spychalska, Victoria Kononets, Dagmara Woźniak, Edyta Mądry, Jarosław Walkowiak   +9 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Oxalate nephropathy after pancreaticoduodenectomy: a case report

BMC Nephrology
A 75-year-old male developed acute kidney injury KDIGO stage 3 a few weeks after Whipple surgery was performed for a distal cholangiocarcinoma. Kidney biopsy revealed oxalate nephropathy. This was attributed to post-Whipple malabsorption, poor compliance
Claire Barani, Selda Aydin, Nathalie Demoulin, Michel Jadoul   +3 more
doaj   +1 more source

Chronic pancreatitis: review and update of etiology, risk factors, and management [version 1; referees: 2 approved]

F1000Research, 2018
Chronic pancreatitis is a syndrome involving inflammation, fibrosis, and loss of acinar and islet cells which can manifest in unrelenting abdominal pain, malnutrition, and exocrine and endocrine insufficiency.
Angela Pham, Christopher Forsmark
doaj   +1 more source

Long term follow-up of a simplified and less burdened pancreatic duct ligation model of exocrine pancreatic insufficiency in Goettingen Minipigs

BMC Gastroenterology, 2020
Background Pancreatic duct ligation in a minipig model leads to exocrine pancreatic insufficiency (EPI). This allows the study of digestive processes and pancreatic enzyme replacement therapies.
Andreas Minh Luu, Alexander Brock, Sabrina Ritz, Sandra Junghänel, Ingo Aldag, Stella Edskes, Marcus Hartmann, Michael Hessler, Michael Praktiknjo, Philip Arnemann, Christian Ertmer, Waldemar Uhl, Juergen Schnekenburger, Torsten Herzog   +13 more
doaj   +1 more source