Results 91 to 100 of about 357,399 (291)

Treatment failure in celiac disease due to coexistent exocrine pancreatic insufficiency

, 1987
A 17-year-old white adolescent had a history of chronic diarrhea, delayed puberty, and growth failure. Investigations excluded cystic fibrosis, Shwachman syndrome, and endocrine causes of growth failure.
Weizman, Z., Cleghorn, G.J., Kopelman, H.R., Durie, P.R., Hamilton, J.R.   +4 more
core  

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Diabetes and the risk of pancreatic cancer.

, 1994
BACKGROUND: Diabetes and pancreatic cancer are known to be associated, but the cause of the association and whether diabetes is a risk factor for pancreatic cancer remain controversial.
Morselli Labate AM, PASQUALI, CLAUDIO, Italian Pancreatic Cancer Study Group, Gullo L, Pezzilli R, SPERTI, COSIMO   +5 more
core   +1 more source

Computation and Structure‐Guided Arginine Scanning Engineers a Hyperactive AP Endonuclease for Multiplex Viral RNA Sensing

Advanced Science, EarlyView.
Computational and structure‐guided arginine scanning rewires the DNA‐binding interface of APE1 to create APE1‐Evo, a hyperactive yet specific AP endonuclease. Integrated into the NAPTUNE‐V2.0 cascade, APE1‐Evo enables amplification‐free, multiplex viral RNA sensing for dengue virus and influenza A/B, highlighting a general strategy for engineering ...
Junlan Wang, Ting Wu, Feizuo Wang, Boyang Wang, Xin Yu Wong, Senfeng Zhang, Shengsheng Ma, Yao Liu, Fangyao Yao, Zhifeng Zeng, Siyuan Yang, Kunming Liu, Qi Wang, Yilong Wang, Yunxiang Zang, Xiaolong Wang, Xingxu Huang, Shao Li, Quanquan Ji, Tao Hu, Chunyi Hu   +20 more
wiley   +1 more source

Etiology, diagnosis, and management of chronic pancreatitis associated primary complications: a narrative review

Frontiers in Medicine
Chronic pancreatitis is a progressive inflammatory disease, whose hallmark pathological feature is an irreversible fibrosis process. This process further leads to irreversible structural damage, pancreatic functional decline, and a variety of severe ...
Liqi Sun, Liqi Sun, Mengruo Jiang, Xiaoyun Wang, Xiaoyun Wang, Yuwei Sun, Yatao Tu, Zhaoshen Li, Zhaoshen Li, Lisi Peng, Lisi Peng, Haojie Huang, Haojie Huang   +12 more
doaj   +1 more source

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

Advanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li, Zhongguo Ren, Yiliang Lin, Xianfeng Xia, Tianlong Li, Kai Fung Chan, Philip Wai Yan Chiu, Wei Peng Yong, Mengmeng Sun   +8 more
wiley   +1 more source

Effects of Pancreatic Duct Stenting on Nutrition and Pancreatic Function in Unresectable Pancreatic Cancer: A Pilot Study

JGH Open
Aims Malnutrition due to pancreatic enzyme insufficiency and cancer‐related systemic effects is common in advanced pancreatic cancer and worsens survival.
Ko Watsuji, Kenji Ikezawa, Yugo Kai, Ryoji Takada, Masaki Kawabata, Hiroki Kishimoto, Kana Hosokawa, Yusuke Seiki, Kazuhiro Kozumi, Makiko Urabe, Kaori Mukai, Tasuku Nakabori, Kazuyoshi Ohkawa   +12 more
doaj   +1 more source

RGS16 Aggravates Hepatic Ischemia‐Reperfusion Injury via Hepatocyte‐Intrinsic Apoptosis/Inflammation & Neutrophil Recruitment/NETosis

Advanced Science, EarlyView.
RGS16 competitively interferes with the YTHDF3–PAN3 complex to prevent CXCL1 mRNA decay during hepatic ischemia‐reperfusion injury. Stabilized CXCL1 strengthens hepatocyte injury, neutrophil recruitment, and NET‐associated inflammation, uncovering how stress‐induced RGS16 converts post‐transcriptional regulation into immune‐mediated liver damage ...
Xinglong Li, Zhanzhi Meng, Hongjun Yu, Yongliang Hua, Zihao Li, Bing Yin, Baolin Qian, Zhongyu Li, Yongzhi Zhou, Zhigang Feng, Shounan Lu, Shanjia Ke, Miaoyu Bai, Yao Fu, Wei Tang, Natalia V. Belosludtseva, Yong Ma   +16 more
wiley   +1 more source

Burden of Deep Venous Thrombosis in Gastric and Pancreatic Adenocarcinoma

Journal of Oncological Sciences
Objective: To determine the burden of deep venous thrombosis (DVT) in patients with gastric and pancreatic adenocarcinoma, to identify associated risk factors, and to distinguish modifiable risk factors.
Zehra SUCUOĞLU İŞLEYEN, Abdülkerim ÖZHAN   +1 more
doaj   +1 more source

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

Advanced Science, EarlyView.
LA‐LYTAC repurposes the cancer‐enriched amino acid transporter LAT1 as a lysosomal trafficking receptor for targeted membrane‐protein degradation. A single phenylalanine‐derived ligand, modularly linked to antibodies or small‐molecule binders, recruits PD‐L1, EGFR, or integrins to LAT1, triggering transporter‐mediated internalization, lysosomal ...
Liquan Zhu, Ke Liu, Haotian Liu, Chaoqi He, Xiaozhen Liu, Xin Zeng, Misha Mao, Yuxiao Mu, Ying Li, Qinghui Zheng, Hongchao Tang, Da Qian, Xuli Meng   +12 more
wiley   +1 more source