Results 101 to 110 of about 527,417 (294)
Diabetes, Obesity and Metabolism, EarlyView.Abstract Aim Eloralintide (LY3841136) is a potent, long‐acting selective amylin receptor agonist currently under development for the treatment of obesity with once‐weekly subcutaneous dosing. Materials and Methods This 12‐week Phase 1, randomised, placebo‐controlled, participant‐ and investigator‐blinded, multiple ascending dose study evaluated the ...
Shobha Bhattachar +8 more
wiley +1 more source
The features of beta-cells organization in the pancreas of spontaneously hypertensive rat (SHR)
Patologìâ, 2016 The control of b-cells pool in patients with hypertension is an actual problem, as it is possible that the hereditary genetic defects of arterial hypertension formation may affect the mechanisms of endocrine cell mass maintenance in pancreas and cause ...
T. V. Abramova, Yu. M. Kolesnyk
doaj +1 more source
Diabetes, Obesity and Metabolism, EarlyView.Abstract Aims/Hypothesis Pancreatic beta‐cell dysfunction is pivotal in diabetes pathogenesis, with the NOD‐like receptor protein 3 (NLRP3) inflammasome playing a crucial role. Dapansutrile (DAPA), a novel NLRP3 inhibitor, demonstrates promise in diabetes management.
Ying Wu +6 more
wiley +1 more source
Altered microvasculature in pancreatic islets from subjects with type 1 diabetes
PLoS ONE, 2022 Aims The transcriptome of different dissociated pancreatic islet cells has been described in enzymatically isolated islets in both health and disease. However, the isolation, culturing, and dissociation procedures likely affect the transcriptome profiles,
Louise Granlund +4 more
doaj
Diabetes, Obesity and Metabolism, EarlyView.Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease that results in loss of insulin‐secreting pancreatic β‐cells in the islets of Langerhans. A diagnosis of T1D is typically associated with children and adolescents, yet half of all diagnoses of T1D are made in adults.
Sufyan Hussain +16 more
wiley +1 more source
Stillbirth in pregnancies with flat OGTT: Placental clues to occult maternal dysmetabolism
International Journal of Gynecology &Obstetrics, EarlyView.
Emma Bertucci +10 more
wiley +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aim To describe the first Italian experience with teplizumab administered under a compassionate use programme for adults with Stage 2 type 1 diabetes (T1D), and to evaluate its feasibility, safety and early metabolic outcomes in a real‐life clinical setting outside formal clinical trials.
V. Guarnotta +6 more
wiley +1 more source
Cell Transplantation, 2006 Development of an efficient preculture system of islets is ideal. Toward that goal, we constructed a human pancreatic islet-derived fibroblast cell line MNNK-1 for a source as a coculture system for freshly isolated islets to maintain islet functions ...
Atsushi Miki +15 more
doaj +1 more source
Regulation of Insulin Secretion Through Long‐Chain Fatty Acid Receptors
iNew Medicine, EarlyView.
Stefan Offermanns
wiley +1 more source
Antibiotic Exposure in Early Life and Risk of Type 1 Diabetes: A Meta‐Analysis
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Background Early‐life antibiotic use may increase the risk of childhood type 1 diabetes (T1D), potentially through gut microbiota dysbiosis and associated effects on immune development. This meta‐analysis evaluated associations between early‐life antibiotic use and T1D.
Sharan Ram +5 more
wiley +1 more source