Results 181 to 190 of about 115,516 (324)

Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes

, 2022
Maria Fasolino, Gregory W. Schwartz, Abhijeet R. Patil, Aanchal Mongia, Maria L. Golson, Yue J. Wang, Ashleigh Morgan, Chengyang Liu, Jonathan Schug, Jinping Liu, Minghui Wu, Daniel Traum, Ayano Kondo, Catherine Lee May, Naomi Goldman, Wenliang Wang, Michael D. Feldman, Jason H. Moore, Alberto Sada Japp, Michael R. Betts, Maria Fasolino, Gregory W. Schwartz, Abhijeet R. Patil, Aanchal Mongia, Maria L. Golson, Yue J. Wang, Ashleigh Morgan, Chengyang Liu, Jonathan Schug, Jinping Liu, Minghui Wu, Daniel Traum, Ayano Kondo, Catherine Lee May, Naomi Goldman, Wenliang Wang, Michael D. Feldman, Jason H. Moore, Alberto Sada Japp, Michael R. Betts, Robert B. Faryabi, Ali Naji, Klaus H. Kaestner, Golnaz Vahedi, Robert B. Faryabi, Ali Naji, Klaus H. Kaestner, Golnaz Vahedi   +47 more
openalex   +2 more sources

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

The physiological role of β-cell heterogeneity in pancreatic islet function

, 2021
Richard K.P. Benninger, Vira Kravets
openalex   +2 more sources

Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders

MedComm, Volume 7, Issue 4, April 2026.
CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley   +1 more source

Pericytes Are Not Merely Accessory Cells in Pancreatic Islets. [PDF]

Diabetes
Mateus Gonçalves L, Almaça J.
europepmc   +1 more source

NR3C1, LAX1, and RCAN3 as Circulating Epigenetic Biomarkers for Prognosis and Chemotherapy Response Prediction in Metastatic Pancreatic Cancer

MedComm, Volume 7, Issue 4, April 2026.
Clinical utility of liquid biopsy‐based epigenetic profiling in PDAC management. Aberrant methylation of LAX1, RCAN3, and NR3C1 was identified in cfDNA from mPDAC patients, highlighting their potential as non‐invasive epigenetic biomarkers. Methylation levels of these genes showed prognostic value, supporting their relevance for patient stratification ...
Pablo Cano‐Ramírez, Marta Toledano‐Fonseca, María Teresa Cano‐Osuna, Nerea Herrera‐Casanova, Emilio Carrillo‐Pecero, Antonio Rodríguez‐Ariza, Enrique Aranda, María Victoria García‐Ortiz   +7 more
wiley   +1 more source

Microbiome‐Based Clustering Identifies Glycemic Control‐Related Subtypes in Youth With Recent‐Onset Type 1 Diabetes

MedComm, Volume 7, Issue 4, April 2026.
Microbiome‐based clustering investigated possible glycemic control‐related endotypes in youth with recent‐onset T1D, and found a potential role of Bacteroides and skatole production in glycemic control. This study offers novel perspectives on the influence of intestinal microbes and its metabolites in T1D heterogeneity and lays a foundation for future ...
Huiling Tan, Yu Ding, Zhaohe Gu, Xulin Wang, Jing Wang, Tian Wei, Xiaoya Zhang, Lanxin Pan, Yu Shi, Shiru Chang, Chuang Guo, Jianping Weng, Xueying Zheng, Tong Yue   +13 more
wiley   +1 more source

Joint TOS/OMA/OAC Expert Guidance Statement on the Pharmacological Management of United States Adults With Overweight or Obesity Using the GRADE Approach

Obesity, Volume 34, Issue 4, Page 851-870, April 2026.
Guidance recommendations by TOS/OMA/OAC for the use of obesity medications to treat obesity and its complications. ABSTRACT Background Obesity affects over 40% of US adults, with severe obesity on the rise. Despite recognition of obesity as a chronic disease, it remains underdiagnosed and undertreated.
Lydia Alexander, Jonathan Q. Purnell, Karlijn Burridge, Marc‐André Cornier, Angela Golden, Deborah Bade Horn, Michelle Look, Joe Nadglowski, Camila Ávila‐Oliver, Francisco Novillo, Ana María Rojas‐Gómez, Brad Hussey, Ximena Ramos Salas   +12 more
wiley   +1 more source

Structural and morphological dynamics of “on‐path” and “off‐path” oligomers of human islet amyloid polypeptide

Protein Science, Volume 35, Issue 4, April 2026.
Abstract The deposition of cytotoxic human islet amyloid polypeptide (IAPP) aggregates is a hallmark feature of Type 2 Diabetes. However, the structural evolution and cytotoxicity of IAPP aggregate species remain poorly understood. This study combines kinetics, biophysical and cell assays to resolve the morphological dynamics of IAPP aggregation. Using
Daniel Warren, Jadon Sitton, Dmitry Kurouski   +2 more
wiley   +1 more source

The Changing Landscape of Chronic Pancreatitis Research Trajectories Over Two Decades: A Global Meta‐Analysis Using MeSH Terms

United European Gastroenterology Journal, Volume 14, Issue 3, April 2026.
ABSTRACT Objectives Significant progress has been made in research on chronic pancreatitis (CP). It is essential to analyze recent trends in this field to guide future clinical investigations. Methods Publications related to CP research from 2000 to 2023 were retrieved from PubMed.
Ling‐Ying Jiang, Chao Wu, Kıvanç Görgülü, Yan‐Wei Lv, Hana Algül, Chao Han, Liang‐Hao Hu   +6 more
wiley   +1 more source