Results 191 to 200 of about 115,516 (324)

Kisspeptin Restores Placental mTOR Signaling and Improves Glucose Homeostasis Mediators Disrupted by Maternal Hypothyroidism in Rats

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Reduced placental mTOR signaling is associated with intrauterine growth restriction and impaired maternal and placental metabolism. Since maternal hypothyroidism induces intrauterine growth restriction, and maternal treatment with kisspeptin‐10 (Kp10) has been shown to improve feto‐placental development in hypothyroid rats, this study ...
Bianca Reis Santos, Jeane Martinha dos Anjos Cordeiro, Luciano Cardoso Santos, Cleisla Souza Oliveira, Maria Clara Pascoal Santos Alvarez, Natália Panhoca Rodrigues, Jorge Lopez‐Tello, Amanda N. Sferruzzi‐Perri, Rogéria Serakides, Juneo Freitas Silva   +9 more
wiley   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Key Matrix Proteins Within the Pancreatic Islet Basement Membrane Are Differentially Digested During Human Islet Isolation [PDF]

, 2016
S. E. Cross, Rebecca H. Vaughan, Abby Willcox, A J McBride, Anju Abraham, Bing Han, Janyne Johnson, Élisa Maillard, Paul Bateman, Reshma Ramracheya, Patrik Rorsman, Karl E. Kadler, Mark J. Dunne, Stephen J. Hughes, Paul Johnson   +14 more
openalex   +1 more source

Characterization of Cytokine Treatment on Human Pancreatic Islets by Top-Down Proteomics. [PDF]

Proteomics
Ives AN, Sagendorf TJ, Nierves L, Lin TT, Dirice E, Kulkarni RN, Paša-Tolić L, Qian WJ, Fulcher JM.   +8 more
europepmc   +1 more source

Fibroblast Growth Factor Receptor-1 Signaling in Pancreatic Islet β-Cells Is Modulated by the Extracellular Matrix [PDF]

, 2007
Dawn M. Kilkenny, Jonathan V. Rocheleau
openalex   +1 more source

The role of membrane excitability in pancreatic β-cell glucotoxicity [PDF]

, 2019
Nichols, Colin G., Remedi, Maria S., Shyr, Zeenat A., Wang, Zhiyu, York, Nathaniel W.   +4 more
core   +1 more source

Eloralintide, a selective, long‐acting amylin receptor agonist for treatment of obesity: Phase 1 proof of concept

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 2651-2660, April 2026.
Abstract Aim Eloralintide (LY3841136) is a potent, long‐acting selective amylin receptor agonist currently under development for the treatment of obesity with once‐weekly subcutaneous dosing. Materials and Methods This 12‐week Phase 1, randomised, placebo‐controlled, participant‐ and investigator‐blinded, multiple ascending dose study evaluated the ...
Shobha Bhattachar, Lai San Tham, Beth Tidemann‐Miller, Hilda Ibriga, Hongchang Qu, Daniel A. Briere, Axel Haupt, Kieren J. Mather, Edward Pratt   +8 more
wiley   +1 more source

Extracellular matrix from decellularized porcine organs as scaffolds for insulin-secreting cells and pancreatic islets. [PDF]

Front Endocrinol (Lausanne)
Dhandapani V, Boabekoa P, Vermette P.
europepmc   +1 more source

Combining quantitative 2D and 3D image analysis in the serial block face SEM: application to secretory organelles of pancreatic islet cells [PDF]

, 2015
Andre Shomorony, Charlotte R. Pfeifer, Maria A. Aronova, G. Zhang, Tao Cai, Hongtao Xu, Abner Louis Notkins, Richard D. Leapman   +7 more
openalex   +1 more source

Dapansutrile preserves pancreatic beta‐cell function by regulating insulin vesicle membrane fusion and mitochondrial homeostasis

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3054-3069, April 2026.
Abstract Aims/Hypothesis Pancreatic beta‐cell dysfunction is pivotal in diabetes pathogenesis, with the NOD‐like receptor protein 3 (NLRP3) inflammasome playing a crucial role. Dapansutrile (DAPA), a novel NLRP3 inhibitor, demonstrates promise in diabetes management.
Ying Wu, Hongxing Fu, Min Zhu, Yuanfa Yao, Luhong Jin, Xihua Lin, Jiaqiang Zhou   +6 more
wiley   +1 more source