Results 251 to 260 of about 116,954 (354)

Evaluating cell-specific gene expression using single-cell and single-nuclei RNA-sequencing data from human pancreatic islets of the same donors. [PDF]

Sci Rep
Engström K, Nilsson Å, Ofori JK, Wierup N, Bacos K, Ling C.   +5 more
europepmc   +1 more source

Type 1 Diabetes and Other Autoimmune Diseases—Epidemiology, Pathophysiology and Screening

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Individuals with type 1 diabetes exhibit significantly increased prevalence of additional autoimmune diseases. Epidemiological, familial and mechanistic evidence indicates frequent polyautoimmunity and shared genetic and environmental drivers. Coexistence complicates clinical management, and autoantibody‐based detection often identifies preclinical ...
George J. Kahaly, Thomas Forst, Monika Kellerer, Stefanie Lanzinger, René D. Rötzer, Matthias Schott, Petra‐Maria Schumm‐Draeger   +6 more
wiley   +1 more source

Integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D-associated genes and regulatory signals. [PDF]

Cell Rep
D'Oliveira Albanus R, Zhang X, Zhao Z, Taylor HJ, Tang X, Han Y, Orchard P, Varshney A, Zhang T, Manickam N, Erdos MR, Narisu N, Taylor L, Saavedra X, Liu X, Zhong A, Li B, Zhou T, Naji A, Liu C, Collins FS, Parker SCJ, Chen S.   +22 more
europepmc   +1 more source

High‐Protein Diet Exacerbates Insulin Resistance via the JNK/IKKβ‐IRS‐1 Pathway

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
A high‐protein diet worsens insulin resistance and β‐cell dysfunction in both normal and T2D mice by increasing hepatic inflammation and suppressing IRS‐1 signalling. Limiting excessive protein intake may help prevent or delay the progression of type 2 diabetes.
Junjun Li, Jinhua Xu, Jinmiao Tian, Lixia Chen, Lili Zhao, Yongming Yang, Jing Wang, Lei Yan, Yuxin Yang, Yuchen Jiang, Simin Chen, Binxuan Wang, Lulu Wang, Xihua Yang   +13 more
wiley   +1 more source

Regulatory T Cells Promote Pancreatic Islet Function and Viability via TGF-β1in vitroandin vivo

, 2018
Bongkum Choi, Sa‐Hyun Kim
openalex   +1 more source

Tirzepatide and Cardiovascular Outcomes: A Narrative Review of Mechanisms, Efficacy and Implications for Heart Failure Management

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Integrated framework for tirzepatide in HFpEF management. Through metabolic, haemodynamic, structural and anti‐inflammatory pathways, tirzepatide modifies the disease trajectory of HFpEF, leading to improvements in symptoms, functional capacity and reduction in HF events.
Hamza A. Abdul‐Hafez, Ameer Awashra, Sosana Bdir, Sarah Saife, Qasem Salah, Mohammed Barbarawi, Thabet Swaileh, Ahmed Emara, Mohamed S. Elgendy, Abdalhakim Shubietah   +9 more
wiley   +1 more source

Expression analysis and possible functional roles of semaphorin/plexin/CRMP families in mouse pancreatic islets. [PDF]

Sci Rep
Kyohara M, Takayanagi R, Tsuno T, Ong Yajima E, Inoue R, Yamashita N, Okuyama T, Nishiyama K, Matsunaga K, Ishida E, Ito S, Terauchi Y, Goshima Y, Shirakawa J.   +13 more
europepmc   +1 more source

Author response: A new mode of pancreatic islet innervation revealed by live imaging in zebrafish

, 2018
Yu Hsuan Carol Yang, Koichi Kawakami, Didier Y. R. Stainier   +2 more
openalex   +1 more source

Therapeutic Potential of Holothuria leucospilota Extract in STZ‐Induced Diabetic Rats: Targeting Inflammation and Apoptosis at the Gene Expression Level

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Holothuria leucospilota n‐hexane extract shows antidiabetic, anti‐inflammatory, and anti‐apoptotic effects in STZ‐induced diabetic rats. The extract modulates key pathways in glucose metabolism, insulin secretion, inflammation, and apoptosis. Treatment significantly decreased glucose and amyloid beta levels, increased insulin, and improved glycemic ...
Niloufar Darbandi, Muhanad Yusif Al‐rikabi   +1 more
wiley   +1 more source

PET imaging of GABA_A receptors in pancreatic islets by [¹¹C]flumazenil. [PDF]

EJNMMI Res
Maloum-Rami F, Cheung P, Antoni G, Jin Z, Eriksson O, Espes D.   +5 more
europepmc   +1 more source